BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 25813626)

  • 1. A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.
    Kim DJ; Park YS; Kim ND; Min SH; You YM; Jung Y; Koo H; Noh H; Kim JA; Park KC; Yeom YI
    Mol Cells; 2015 Apr; 38(4):373-9. PubMed ID: 25813626
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro.
    Yuan S; Qiao T; Zhuang X; Chen W; Xing N; Zhang Q
    Yonsei Med J; 2016 Nov; 57(6):1312-23. PubMed ID: 27593857
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
    Hua Q; Mi B; Xu F; Wen J; Zhao L; Liu J; Huang G
    Theranostics; 2020; 10(11):4762-4778. PubMed ID: 32308748
    [No Abstract]   [Full Text] [Related]  

  • 4. Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
    Prakasam G; Singh RK; Iqbal MA; Saini SK; Tiku AB; Bamezai RNK
    J Biol Chem; 2017 Sep; 292(37):15561-15576. PubMed ID: 28778925
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.
    Dong T; Yan Y; Chai H; Chen S; Xiong X; Sun D; Yu Y; Deng L; Cheng F
    Biomed Pharmacother; 2015 Feb; 69():277-84. PubMed ID: 25661370
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC).
    Li RZ; Fan XX; Shi DF; Zhu GY; Wang YW; Luo LX; Pan HD; Yao XJ; Leung EL; Liu L
    Chem Biol Drug Des; 2018 Nov; 92(5):1851-1858. PubMed ID: 29931766
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.
    Iqbal MA; Siddiqui FA; Chaman N; Gupta V; Kumar B; Gopinath P; Bamezai RN
    J Biol Chem; 2014 Mar; 289(12):8098-105. PubMed ID: 24492614
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer.
    Suzuki A; Puri S; Leland P; Puri A; Moudgil T; Fox BA; Puri RK; Joshi BH
    PLoS One; 2019; 14(5):e0217131. PubMed ID: 31120964
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Computer-aided identification of a novel pyruvate kinase M2 activator compound.
    Li Y; Bao M; Yang C; Chen J; Zhou S; Sun R; Wu C; Li X; Bao J
    Cell Prolif; 2018 Dec; 51(6):e12509. PubMed ID: 30133040
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.
    Gao X; Wang H; Yang JJ; Liu X; Liu ZR
    Mol Cell; 2012 Mar; 45(5):598-609. PubMed ID: 22306293
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
    Yu Z; Zhao X; Huang L; Zhang T; Yang F; Xie L; Song S; Miao P; Zhao L; Sun X; Liu J; Huang G
    J Biol Chem; 2013 Dec; 288(49):35406-16. PubMed ID: 24142698
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
    Luo W; Hu H; Chang R; Zhong J; Knabel M; O'Meally R; Cole RN; Pandey A; Semenza GL
    Cell; 2011 May; 145(5):732-44. PubMed ID: 21620138
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
    Meng MB; Wang HH; Guo WH; Wu ZQ; Zeng XL; Zaorsky NG; Shi HS; Qian D; Niu ZM; Jiang B; Zhao LJ; Yuan ZY; Wang P
    Cancer Lett; 2015 Jan; 356(2 Pt B):985-93. PubMed ID: 25444918
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
    Sun Q; Chen X; Ma J; Peng H; Wang F; Zha X; Wang Y; Jing Y; Yang H; Chen R; Chang L; Zhang Y; Goto J; Onda H; Chen T; Wang MR; Lu Y; You H; Kwiatkowski D; Zhang H
    Proc Natl Acad Sci U S A; 2011 Mar; 108(10):4129-34. PubMed ID: 21325052
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.
    Iqbal MA; Siddiqui FA; Gupta V; Chattopadhyay S; Gopinath P; Kumar B; Manvati S; Chaman N; Bamezai RN
    Mol Cancer; 2013 Jul; 12():72. PubMed ID: 23837608
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.
    Yoon YJ; Kim YH; Jin Y; Chi SW; Moon JH; Han DC; Kwon BM
    Cancer Lett; 2018 Oct; 434():42-55. PubMed ID: 30009856
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2.
    Zhang K; Zhang M; Jiang H; Liu F; Liu H; Li Y
    Biomed Pharmacother; 2018 Sep; 105():545-552. PubMed ID: 29886375
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Knockdown of PKM2 Enhances Radiosensitivity of Non-small cell Lung Cancer.
    Wang S; Ma Y; Wang P; Song Z; Liu B; Sun X; Zhang H; Yu J
    Cell Biochem Biophys; 2015 Sep; 73(1):21-6. PubMed ID: 25649613
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PKM2 and HIF-1α regulation in prostate cancer cell lines.
    Hasan D; Gamen E; Abu Tarboush N; Ismail Y; Pak O; Azab B
    PLoS One; 2018; 13(9):e0203745. PubMed ID: 30216369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells.
    Yu Z; Huang L; Qiao P; Jiang A; Wang L; Yang T; Tang S; Zhang W; Ren C
    Biochem Biophys Res Commun; 2016 May; 473(4):953-958. PubMed ID: 27045080
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.