BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

313 related articles for article (PubMed ID: 25814654)

  • 1. Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity.
    Moussavi Nik SH; Newman M; Wilson L; Ebrahimie E; Wells S; Musgrave I; Verdile G; Martins RN; Lardelli M
    Hum Mol Genet; 2015 Jul; 24(13):3662-78. PubMed ID: 25814654
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Zebrafish Equivalent of Alzheimer's Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress.
    Ebrahimie E; Moussavi Nik SH; Newman M; Van Der Hoek M; Lardelli M
    J Alzheimers Dis; 2016 Mar; 52(2):581-608. PubMed ID: 27031468
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress.
    Moussavi Nik SH; Wilson L; Newman M; Croft K; Mori TA; Musgrave I; Lardelli M
    J Alzheimers Dis; 2012; 28(3):515-30. PubMed ID: 22045484
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.
    Hin N; Newman M; Kaslin J; Douek AM; Lumsden A; Nik SHM; Dong Y; Zhou XF; Mañucat-Tan NB; Ludington A; Adelson DL; Pederson S; Lardelli M
    PLoS One; 2020; 15(1):e0227258. PubMed ID: 31978074
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.
    Jayne T; Newman M; Verdile G; Sutherland G; Münch G; Musgrave I; Moussavi Nik SH; Lardelli M
    J Alzheimers Dis; 2016 Apr; 52(3):781-99. PubMed ID: 27060961
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.
    Nornes S; Newman M; Verdile G; Wells S; Stoick-Cooper CL; Tucker B; Frederich-Sleptsova I; Martins R; Lardelli M
    Hum Mol Genet; 2008 Feb; 17(3):402-12. PubMed ID: 17981814
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.
    Sharman MJ; Moussavi Nik SH; Chen MM; Ong D; Wijaya L; Laws SM; Taddei K; Newman M; Lardelli M; Martins RN; Verdile G
    PLoS One; 2013; 8(6):e66235. PubMed ID: 23805206
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
    J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
    Zhou R; Yang G; Shi Y
    Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in
    Montenegro P; Chen P; Kang J; Lee SH; Leone S; Shen J
    Proc Natl Acad Sci U S A; 2023 Oct; 120(42):e2306714120. PubMed ID: 37816062
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
    Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
    Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease.
    Newman M; Halter L; Lim A; Lardelli M
    PLoS One; 2017; 12(6):e0179859. PubMed ID: 28636676
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease.
    Newman M; Wilson L; Verdile G; Lim A; Khan I; Moussavi Nik SH; Pursglove S; Chapman G; Martins RN; Lardelli M
    Hum Mol Genet; 2014 Feb; 23(3):602-17. PubMed ID: 24101600
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations.
    Pimenova AA; Goate AM
    Neurobiol Dis; 2020 May; 138():104785. PubMed ID: 32032730
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.
    Sannerud R; Esselens C; Ejsmont P; Mattera R; Rochin L; Tharkeshwar AK; De Baets G; De Wever V; Habets R; Baert V; Vermeire W; Michiels C; Groot AJ; Wouters R; Dillen K; Vints K; Baatsen P; Munck S; Derua R; Waelkens E; Basi GS; Mercken M; Vooijs M; Bollen M; Schymkowitz J; Rousseau F; Bonifacino JS; Van Niel G; De Strooper B; Annaert W
    Cell; 2016 Jun; 166(1):193-208. PubMed ID: 27293189
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
    Zhang C; Browne A; Kim DY; Tanzi RE
    Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.