These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

295 related articles for article (PubMed ID: 25814953)

  • 1. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.
    Munday JC; Settimo L; de Koning HP
    Front Pharmacol; 2015; 6():32. PubMed ID: 25814953
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
    Munday JC; Eze AA; Baker N; Glover L; Clucas C; Aguinaga Andrés D; Natto MJ; Teka IA; McDonald J; Lee RS; Graf FE; Ludin P; Burchmore RJ; Turner CM; Tait A; MacLeod A; Mäser P; Barrett MP; Horn D; De Koning HP
    J Antimicrob Chemother; 2014 Mar; 69(3):651-63. PubMed ID: 24235095
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.
    Graf FE; Ludin P; Wenzler T; Kaiser M; Brun R; Pyana PP; Büscher P; de Koning HP; Horn D; Mäser P
    PLoS Negl Trop Dis; 2013; 7(10):e2475. PubMed ID: 24130910
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter
    Alghamdi AH; Munday JC; Campagnaro GD; Gurvic D; Svensson F; Okpara CE; Kumar A; Quintana J; Martin Abril ME; Milić P; Watson L; Paape D; Settimo L; Dimitriou A; Wielinska J; Smart G; Anderson LF; Woodley CM; Kelly SPY; Ibrahim HM; Hulpia F; Al-Salabi MI; Eze AA; Sprenger T; Teka IA; Gudin S; Weyand S; Field M; Dardonville C; Tidwell RR; Carrington M; O'Neill P; Boykin DW; Zachariae U; De Koning HP
    Elife; 2020 Aug; 9():. PubMed ID: 32762841
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
    Matovu E; Stewart ML; Geiser F; Brun R; Mäser P; Wallace LJ; Burchmore RJ; Enyaru JC; Barrett MP; Kaminsky R; Seebeck T; de Koning HP
    Eukaryot Cell; 2003 Oct; 2(5):1003-8. PubMed ID: 14555482
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
    Teka IA; Kazibwe AJ; El-Sabbagh N; Al-Salabi MI; Ward CP; Eze AA; Munday JC; Mäser P; Matovu E; Barrett MP; de Koning HP
    Mol Pharmacol; 2011 Jul; 80(1):110-6. PubMed ID: 21436312
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.
    Bridges DJ; Gould MK; Nerima B; Mäser P; Burchmore RJ; de Koning HP
    Mol Pharmacol; 2007 Apr; 71(4):1098-108. PubMed ID: 17234896
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.
    Graf FE; Baker N; Munday JC; de Koning HP; Horn D; Mäser P
    Int J Parasitol Drugs Drug Resist; 2015 Aug; 5(2):65-8. PubMed ID: 26042196
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
    Baker N; Glover L; Munday JC; Aguinaga Andrés D; Barrett MP; de Koning HP; Horn D
    Proc Natl Acad Sci U S A; 2012 Jul; 109(27):10996-1001. PubMed ID: 22711816
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
    Munday JC; Rojas López KE; Eze AA; Delespaux V; Van Den Abbeele J; Rowan T; Barrett MP; Morrison LJ; de Koning HP
    Int J Parasitol Drugs Drug Resist; 2013 Dec; 3():69-76. PubMed ID: 24533295
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
    Pyana Pati P; Van Reet N; Mumba Ngoyi D; Ngay Lukusa I; Karhemere Bin Shamamba S; Büscher P
    PLoS Negl Trop Dis; 2014 Oct; 8(10):e3212. PubMed ID: 25275572
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
    Munday JC; Tagoe DN; Eze AA; Krezdorn JA; Rojas López KE; Alkhaldi AA; McDonald F; Still J; Alzahrani KJ; Settimo L; De Koning HP
    Mol Microbiol; 2015 May; 96(4):887-900. PubMed ID: 25708978
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into drug transport by an aquaglyceroporin.
    Chen W; Zou R; Mei Y; Li J; Xuan Y; Cui B; Zou J; Wang J; Lin S; Zhang Z; Wang C
    Nat Commun; 2024 May; 15(1):3985. PubMed ID: 38734677
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of
    Ungogo MA; Campagnaro GD; Alghamdi AH; Natto MJ; de Koning HP
    Int J Mol Sci; 2022 Mar; 23(5):. PubMed ID: 35269985
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei.
    Carter NS; Berger BJ; Fairlamb AH
    J Biol Chem; 1995 Nov; 270(47):28153-7. PubMed ID: 7499305
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2.
    Song J; Baker N; Rothert M; Henke B; Jeacock L; Horn D; Beitz E
    PLoS Pathog; 2016 Feb; 12(2):e1005436. PubMed ID: 26828608
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.
    Quintana JF; Bueren-Calabuig J; Zuccotto F; de Koning HP; Horn D; Field MC
    PLoS Negl Trop Dis; 2020 Jul; 14(7):e0008458. PubMed ID: 32644992
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.
    De Koning HP
    Mol Pharmacol; 2001 Mar; 59(3):586-92. PubMed ID: 11179454
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.
    Stewart ML; Burchmore RJ; Clucas C; Hertz-Fowler C; Brooks K; Tait A; Macleod A; Turner CM; De Koning HP; Wong PE; Barrett MP
    Eukaryot Cell; 2010 Feb; 9(2):336-43. PubMed ID: 19966032
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.
    Barrett MP; Zhang ZQ; Denise H; Giroud C; Baltz T
    Mol Biochem Parasitol; 1995 Jul; 73(1-2):223-9. PubMed ID: 8577330
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.