BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 25819333)

  • 1. Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
    Zakharenko A; Khomenko T; Zhukova S; Koval O; Zakharova O; Anarbaev R; Lebedeva N; Korchagina D; Komarova N; Vasiliev V; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2015 May; 23(9):2044-52. PubMed ID: 25819333
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
    Conda-Sheridan M; Reddy PV; Morrell A; Cobb BT; Marchand C; Agama K; Chergui A; Renaud A; Stephen AG; Bindu LK; Pommier Y; Cushman M
    J Med Chem; 2013 Jan; 56(1):182-200. PubMed ID: 23259865
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.
    Zakharenko A; Luzina O; Koval O; Nilov D; Gushchina I; Dyrkheeva N; Švedas V; Salakhutdinov N; Lavrik O
    J Nat Prod; 2016 Nov; 79(11):2961-2967. PubMed ID: 27933897
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
    Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
    J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
    Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
    J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.
    Lv PC; Agama K; Marchand C; Pommier Y; Cushman M
    J Med Chem; 2014 May; 57(10):4324-36. PubMed ID: 24800942
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2
    Li-Zhulanov NS; Zakharenko AL; Chepanova AA; Patel J; Zafar A; Volcho KP; Salakhutdinov NF; Reynisson J; Leung IKH; Lavrik OI
    Molecules; 2018 Sep; 23(10):. PubMed ID: 30261631
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.
    Nguyen TX; Abdelmalak M; Marchand C; Agama K; Pommier Y; Cushman M
    J Med Chem; 2015 Apr; 58(7):3188-208. PubMed ID: 25811317
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
    Zakharova O; Luzina O; Zakharenko A; Sokolov D; Filimonov A; Dyrkheeva N; Chepanova A; Ilina E; Ilyina A; Klabenkova K; Chelobanov B; Stetsenko D; Zafar A; Eurtivong C; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2018 Aug; 26(15):4470-4480. PubMed ID: 30076000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties.
    Khomenko T; Zakharenko A; Odarchenko T; Arabshahi HJ; Sannikova V; Zakharova O; Korchagina D; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2016 Nov; 24(21):5573-5581. PubMed ID: 27658793
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy.
    Komarova AO; Drenichev MS; Dyrkheeva NS; Kulikova IV; Oslovsky VE; Zakharova OD; Zakharenko AL; Mikhailov SN; Lavrik OI
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):1415-1429. PubMed ID: 30191738
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
    Salomatina OV; Dyrkheeva NS; Popadyuk II; Zakharenko AL; Ilina ES; Komarova NI; Reynisson J; Salakhutdinov NF; Lavrik OI; Volcho KP
    Molecules; 2021 Dec; 27(1):. PubMed ID: 35011303
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides.
    Jun JH; Kumar V; Dexheimer TS; Wedlich I; Nicklaus MC; Pommier Y; Malhotra SV
    Eur J Pharm Sci; 2018 Jan; 111():337-348. PubMed ID: 29037996
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
    Nguyen TX; Morrell A; Conda-Sheridan M; Marchand C; Agama K; Bermingham A; Bermingam A; Stephen AG; Chergui A; Naumova A; Fisher R; O'Keefe BR; Pommier Y; Cushman M
    J Med Chem; 2012 May; 55(9):4457-78. PubMed ID: 22536944
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
    Khomenko TM; Zakharenko AL; Chepanova AA; Ilina ES; Zakharova OD; Kaledin VI; Nikolin VP; Popova NA; Korchagina DV; Reynisson J; Chand R; Ayine-Tora DM; Patel J; Leung IKH; Volcho KP; Salakhutdinov NF; Lavrik OI
    Int J Mol Sci; 2019 Dec; 21(1):. PubMed ID: 31878088
    [TBL] [Abstract][Full Text] [Related]  

  • 17. New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
    Salomatina OV; Kornienko TE; Zakharenko AL; Komarova NI; Achara C; Reynisson J; Salakhutdinov NF; Lavrik OI; Volcho KP
    Molecules; 2024 Jan; 29(3):. PubMed ID: 38338326
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
    Filimonov AS; Chepanova AA; Luzina OA; Zakharenko AL; Zakharova OD; Ilina ES; Dyrkheeva NS; Kuprushkin MS; Kolotaev AV; Khachatryan DS; Patel J; Leung IKH; Chand R; Ayine-Tora DM; Reynisson J; Volcho KP; Salakhutdinov NF; Lavrik OI
    Molecules; 2019 Oct; 24(20):. PubMed ID: 31619021
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
    Huang SN; Pommier Y; Marchand C
    Expert Opin Ther Pat; 2011 Sep; 21(9):1285-92. PubMed ID: 21843105
    [TBL] [Abstract][Full Text] [Related]  

  • 20. New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition.
    Dyrkheeva NS; Filimonov AS; Luzina OA; Zakharenko AL; Ilina ES; Malakhova AA; Medvedev SP; Reynisson J; Volcho KP; Zakian SM; Salakhutdinov NF; Lavrik OI
    Biomolecules; 2021 Jul; 11(7):. PubMed ID: 34356597
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.