BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 25823821)

  • 1. Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development.
    Deng R; Zhao X; Qu Y; Chen C; Zhu C; Zhang H; Yuan H; Jin H; Liu X; Wang Y; Chen Q; Huang J; Yu J
    Oncotarget; 2015 Apr; 6(11):9355-69. PubMed ID: 25823821
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SHP2 is induced by the HBx-NF-κB pathway and contributes to fibrosis during human early hepatocellular carcinoma development.
    Kang HJ; Chung DH; Sung CO; Yoo SH; Yu E; Kim N; Lee SH; Song JY; Kim CJ; Choi J
    Oncotarget; 2017 Apr; 8(16):27263-27276. PubMed ID: 28460481
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase.
    Miura K; Wakayama Y; Tanino M; Orba Y; Sawa H; Hatakeyama M; Tanaka S; Sabe H; Mochizuki N
    Oncogene; 2013 Nov; 32(45):5292-301. PubMed ID: 23318428
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Neuroglobin, a novel intracellular hexa-coordinated globin, functions as a tumor suppressor in hepatocellular carcinoma via Raf/MAPK/Erk.
    Zhang J; Lan SJ; Liu QR; Liu JM; Chen XQ
    Mol Pharmacol; 2013 May; 83(5):1109-19. PubMed ID: 23478801
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.
    Meng S; Chen Z; Munoz-Antonia T; Wu J
    Biochem J; 2005 Oct; 391(Pt 1):143-51. PubMed ID: 15952937
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oncogenic Shp2 disturbs microtubule regulation to cause HDAC6-dependent ERK hyperactivation.
    Tien SC; Chang ZF
    Oncogene; 2014 May; 33(22):2938-46. PubMed ID: 23770849
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
    Hu Z; Wang X; Fang H; Liu Y; Chen D; Zhang Q; Liu X; Wei D; Qu C; Wang S
    Oncotarget; 2016 Feb; 7(5):5664-76. PubMed ID: 26673822
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.
    McPherson VA; Sharma N; Everingham S; Smith J; Zhu HH; Feng GS; Craig AW
    J Immunol; 2009 Oct; 183(8):4940-7. PubMed ID: 19786542
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.
    Chen WS; Liang Y; Zong M; Liu JJ; Kaneko K; Hanley KL; Zhang K; Feng GS
    Cell Rep; 2021 Nov; 37(6):109974. PubMed ID: 34758313
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory.
    Ryu HH; Kim T; Kim JW; Kang M; Park P; Kim YG; Kim H; Ha J; Choi JE; Lee J; Lim CS; Kim CH; Kim SJ; Silva AJ; Kaang BK; Lee YS
    Sci Signal; 2019 Mar; 12(571):. PubMed ID: 30837304
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
    Chen YN; LaMarche MJ; Chan HM; Fekkes P; Garcia-Fortanet J; Acker MG; Antonakos B; Chen CH; Chen Z; Cooke VG; Dobson JR; Deng Z; Fei F; Firestone B; Fodor M; Fridrich C; Gao H; Grunenfelder D; Hao HX; Jacob J; Ho S; Hsiao K; Kang ZB; Karki R; Kato M; Larrow J; La Bonte LR; Lenoir F; Liu G; Liu S; Majumdar D; Meyer MJ; Palermo M; Perez L; Pu M; Price E; Quinn C; Shakya S; Shultz MD; Slisz J; Venkatesan K; Wang P; Warmuth M; Williams S; Yang G; Yuan J; Zhang JH; Zhu P; Ramsey T; Keen NJ; Sellers WR; Stams T; Fortin PD
    Nature; 2016 Jul; 535(7610):148-52. PubMed ID: 27362227
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration.
    Chiu CY; Kuo KK; Kuo TL; Lee KT; Cheng KH
    Mol Cancer Res; 2012 Mar; 10(3):415-27. PubMed ID: 22241220
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients.
    Han T; Xiang DM; Sun W; Liu N; Sun HL; Wen W; Shen WF; Wang RY; Chen C; Wang X; Cheng Z; Li HY; Wu MC; Cong WM; Feng GS; Ding J; Wang HY
    J Hepatol; 2015 Sep; 63(3):651-60. PubMed ID: 25865556
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.
    Sun CK; Man K; Ng KT; Ho JW; Lim ZX; Cheng Q; Lo CM; Poon RT; Fan ST
    Carcinogenesis; 2008 Nov; 29(11):2096-105. PubMed ID: 18765415
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs.
    Wei Q; Luo S; He G
    Sci Rep; 2024 Apr; 14(1):9128. PubMed ID: 38644382
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.
    Chen C; Cao M; Zhu S; Wang C; Liang F; Yan L; Luo D
    Sci Rep; 2015 Dec; 5():17626. PubMed ID: 26626996
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway.
    Takeishi K; Taketomi A; Shirabe K; Toshima T; Motomura T; Ikegami T; Yoshizumi T; Sakane F; Maehara Y
    J Hepatol; 2012 Jul; 57(1):77-83. PubMed ID: 22425622
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells.
    Zhao D; Zhai B; He C; Tan G; Jiang X; Pan S; Dong X; Wei Z; Ma L; Qiao H; Jiang H; Sun X
    Cell Signal; 2014 May; 26(5):1030-9. PubMed ID: 24486412
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.
    Quintanar-Audelo M; Yusoff P; Sinniah S; Chandramouli S; Guy GR
    J Biol Chem; 2011 Jul; 286(26):23102-12. PubMed ID: 21531714
    [TBL] [Abstract][Full Text] [Related]  

  • 20. EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1.
    Buonato JM; Lan IS; Lazzara MJ
    J Cell Sci; 2015 Nov; 128(21):3898-909. PubMed ID: 26359300
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.