BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 25853628)

  • 1. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.
    Lavrado J; Brito H; Borralho PM; Ohnmacht SA; Kim NS; Leitão C; Pisco S; Gunaratnam M; Rodrigues CM; Moreira R; Neidle S; Paulo A
    Sci Rep; 2015 Apr; 5():9696. PubMed ID: 25853628
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.
    Brito H; Martins AC; Lavrado J; Mendes E; Francisco AP; Santos SA; Ohnmacht SA; Kim NS; Rodrigues CM; Moreira R; Neidle S; Borralho PM; Paulo A
    PLoS One; 2015; 10(5):e0126891. PubMed ID: 26024321
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.
    Lavrado J; Ohnmacht SA; Correia I; Leitão C; Pisco S; Gunaratnam M; Moreira R; Neidle S; Santos DJ; Paulo A
    ChemMedChem; 2015 May; 10(5):836-49. PubMed ID: 25820698
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.
    Lavrado J; Borralho PM; Ohnmacht SA; Castro RE; Rodrigues CM; Moreira R; dos Santos DJ; Neidle S; Paulo A
    ChemMedChem; 2013 Oct; 8(10):1648-61. PubMed ID: 23960016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners.
    Wang L; Switalska M; Mei ZW; Lu WJ; Takahara Y; Feng XW; El-Sayed Iel-T; Wietrzyk J; Inokuchi T
    Bioorg Med Chem; 2012 Aug; 20(15):4820-9. PubMed ID: 22748378
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells.
    Nagesh N; Raju G; Srinivas R; Ramesh P; Reddy MD; Reddy ChR
    Biochim Biophys Acta; 2015 Jan; 1850(1):129-40. PubMed ID: 25452213
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
    Liu HY; Chen AC; Yin QK; Li Z; Huang SM; Du G; He JH; Zan LP; Wang SK; Xu YH; Tan JH; Ou TM; Li D; Gu LQ; Huang ZS
    J Med Chem; 2017 Jul; 60(13):5438-5454. PubMed ID: 28603988
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cryptolepine and aromathecin based mimics as potent G-quadruplex-binding, DNA-cleavage and anticancer agents: Design, synthesis and DNA targeting-induced apoptosis.
    Yuan JM; Wei K; Zhang GH; Chen NY; Wei XW; Pan CX; Mo DL; Su GF
    Eur J Med Chem; 2019 May; 169():144-158. PubMed ID: 30875505
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
    Ou TM; Lu YJ; Zhang C; Huang ZS; Wang XD; Tan JH; Chen Y; Ma DL; Wong KY; Tang JC; Chan AS; Gu LQ
    J Med Chem; 2007 Apr; 50(7):1465-74. PubMed ID: 17346034
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.
    Boddupally PV; Hahn S; Beman C; De B; Brooks TA; Gokhale V; Hurley LH
    J Med Chem; 2012 Jul; 55(13):6076-86. PubMed ID: 22691117
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions.
    Jana J; Mondal S; Bhattacharjee P; Sengupta P; Roychowdhury T; Saha P; Kundu P; Chatterjee S
    Sci Rep; 2017 Jan; 7():40706. PubMed ID: 28102286
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives.
    Catalano R; Moraca F; Amato J; Cristofari C; Rigo R; Via LD; Rocca R; Lupia A; Maruca A; Costa G; Catalanotti B; Artese A; Pagano B; Randazzo A; Sissi C; Novellino E; Alcaro S
    Eur J Med Chem; 2019 Nov; 182():111627. PubMed ID: 31446246
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.
    Arafa RK; Hegazy GH; Piazza GA; Abadi AH
    Eur J Med Chem; 2013 May; 63():826-32. PubMed ID: 23584545
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors.
    Luniewski W; Wietrzyk J; Godlewska J; Switalska M; Piskozub M; Peczynska-Czoch W; Kaczmarek L
    Bioorg Med Chem Lett; 2012 Oct; 22(19):6103-7. PubMed ID: 22944121
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex.
    Das RN; Chevret E; Desplat V; Rubio S; Mergny JL; Guillon J
    Molecules; 2017 Dec; 23(1):. PubMed ID: 29301210
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines.
    Wang N; Świtalska M; Wu MY; Imai K; Ngoc TA; Pang CQ; Wang L; Wietrzyk J; Inokuchi T
    Eur J Med Chem; 2014 May; 78():314-23. PubMed ID: 24686018
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
    Beauchard A; Jaunet A; Murillo L; Baldeyrou B; Lansiaux A; Chérouvrier JR; Domon L; Picot L; Bailly C; Besson T; Thiéry V
    Eur J Med Chem; 2009 Oct; 44(10):3858-65. PubMed ID: 19427714
    [TBL] [Abstract][Full Text] [Related]  

  • 18. RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.
    Miglietta G; Cogoi S; Marinello J; Capranico G; Tikhomirov AS; Shchekotikhin A; Xodo LE
    J Med Chem; 2017 Dec; 60(23):9448-9461. PubMed ID: 29140695
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
    Ou TM; Lin J; Lu YJ; Hou JQ; Tan JH; Chen SH; Li Z; Li YP; Li D; Gu LQ; Huang ZS
    J Med Chem; 2011 Aug; 54(16):5671-9. PubMed ID: 21774525
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.
    Chan DS; Yang H; Kwan MH; Cheng Z; Lee P; Bai LP; Jiang ZH; Wong CY; Fong WF; Leung CH; Ma DL
    Biochimie; 2011 Jun; 93(6):1055-64. PubMed ID: 21377506
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.