These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 25867140)

  • 1. Functional reconstitution and channel activity measurements of purified wildtype and mutant CFTR protein.
    Eckford PD; Li C; Bear CE
    J Vis Exp; 2015 Mar; (97):. PubMed ID: 25867140
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of the adenosinetriphosphatase and transport activities of purified cystic fibrosis transmembrane conductance regulator.
    Ketchum CJ; Rajendrakumar GV; Maloney PC
    Biochemistry; 2004 Feb; 43(4):1045-53. PubMed ID: 14744150
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
    Eckford PD; Li C; Ramjeesingh M; Bear CE
    J Biol Chem; 2012 Oct; 287(44):36639-49. PubMed ID: 22942289
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.
    Wei S; Roessler BC; Chauvet S; Guo J; Hartman JL; Kirk KL
    J Biol Chem; 2014 Jul; 289(29):19942-57. PubMed ID: 24876383
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation.
    Meng X; Wang Y; Wang X; Wrennall JA; Rimington TL; Li H; Cai Z; Ford RC; Sheppard DN
    J Biol Chem; 2017 Mar; 292(9):3706-3719. PubMed ID: 28087700
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
    Pasyk S; Li C; Ramjeesingh M; Bear CE
    Biochem J; 2009 Feb; 418(1):185-90. PubMed ID: 18945216
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS.
    Corradi V; Vergani P; Tieleman DP
    J Biol Chem; 2015 Sep; 290(38):22891-906. PubMed ID: 26229102
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure.
    Linsdell P
    Channels (Austin); 2018; 12(1):284-290. PubMed ID: 30152709
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.
    Liu J; Berg AP; Wang Y; Jantarajit W; Sutcliffe KJ; Stevens EB; Cao L; Pregel MJ; Sheppard DN
    Br J Pharmacol; 2022 Apr; 179(7):1319-1337. PubMed ID: 34644413
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ATPase activity of the cystic fibrosis transmembrane conductance regulator.
    Li C; Ramjeesingh M; Wang W; Garami E; Hewryk M; Lee D; Rommens JM; Galley K; Bear CE
    J Biol Chem; 1996 Nov; 271(45):28463-8. PubMed ID: 8910473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.
    Csanády L; Chan KW; Nairn AC; Gadsby DC
    J Gen Physiol; 2005 Jan; 125(1):43-55. PubMed ID: 15596536
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.
    Jordan IK; Kota KC; Cui G; Thompson CH; McCarty NA
    Proc Natl Acad Sci U S A; 2008 Dec; 105(48):18865-70. PubMed ID: 19020075
    [TBL] [Abstract][Full Text] [Related]  

  • 13. G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects.
    Bompadre SG; Sohma Y; Li M; Hwang TC
    J Gen Physiol; 2007 Apr; 129(4):285-98. PubMed ID: 17353351
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR.
    Xu Z; Pissarra LS; Farinha CM; Liu J; Cai Z; Thibodeau PH; Amaral MD; Sheppard DN
    J Physiol; 2014 May; 592(9):1931-47. PubMed ID: 24591578
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators protect G551D but not ΔF508 CFTR from thermal instability.
    Liu X; Dawson DC
    Biochemistry; 2014 Sep; 53(35):5613-8. PubMed ID: 25148434
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels.
    Wang F; Zeltwanger S; Hu S; Hwang TC
    J Physiol; 2000 May; 524 Pt 3(Pt 3):637-48. PubMed ID: 10790148
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains.
    Csanády L; Chan KW; Seto-Young D; Kopsco DC; Nairn AC; Gadsby DC
    J Gen Physiol; 2000 Sep; 116(3):477-500. PubMed ID: 10962022
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
    Cai Z; Taddei A; Sheppard DN
    J Biol Chem; 2006 Jan; 281(4):1970-7. PubMed ID: 16311240
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia.
    Dong Q; Ernst SE; Ostedgaard LS; Shah VS; Ver Heul AR; Welsh MJ; Randak CO
    J Biol Chem; 2015 May; 290(22):14140-53. PubMed ID: 25887396
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.
    Tsai MF; Jih KY; Shimizu H; Li M; Hwang TC
    J Biol Chem; 2010 Nov; 285(48):37663-71. PubMed ID: 20861014
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.