These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

378 related articles for article (PubMed ID: 25868605)

  • 1. The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.
    Saunier E; Benelli C; Bortoli S
    Int J Cancer; 2016 Feb; 138(4):809-17. PubMed ID: 25868605
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
    Stacpoole PW
    J Natl Cancer Inst; 2017 Nov; 109(11):. PubMed ID: 29059435
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy.
    Anwar S; Shamsi A; Mohammad T; Islam A; Hassan MI
    Biochim Biophys Acta Rev Cancer; 2021 Aug; 1876(1):188568. PubMed ID: 34023419
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.
    Sugden MC; Holness MJ
    Am J Physiol Endocrinol Metab; 2003 May; 284(5):E855-62. PubMed ID: 12676647
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications.
    Wang X; Shen X; Yan Y; Li H
    Biosci Rep; 2021 Apr; 41(4):. PubMed ID: 33739396
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis.
    Woolbright BL; Rajendran G; Harris RA; Taylor JA
    Mol Cancer Ther; 2019 Oct; 18(10):1673-1681. PubMed ID: 31511353
    [TBL] [Abstract][Full Text] [Related]  

  • 7. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.
    Korotchkina LG; Sidhu S; Patel MS
    Free Radic Res; 2004 Oct; 38(10):1083-92. PubMed ID: 15512796
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
    Zhang W; Zhang SL; Hu X; Tam KY
    Int J Biol Sci; 2015; 11(12):1390-400. PubMed ID: 26681918
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism.
    Park S; Jeon JH; Min BK; Ha CM; Thoudam T; Park BY; Lee IK
    Diabetes Metab J; 2018 Aug; 42(4):270-281. PubMed ID: 30136450
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers.
    Jeoung NH
    Diabetes Metab J; 2015 Jun; 39(3):188-97. PubMed ID: 26124988
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.
    Sugden MC; Holness MJ
    Curr Drug Targets Immune Endocr Metabol Disord; 2002 Jul; 2(2):151-65. PubMed ID: 12476789
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases.
    Reiter RJ; Sharma R; Rosales-Corral S
    Int J Mol Sci; 2021 Jan; 22(2):. PubMed ID: 33466614
    [TBL] [Abstract][Full Text] [Related]  

  • 13. c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons.
    Zhou Q; Lam PY; Han D; Cadenas E
    J Neurochem; 2008 Jan; 104(2):325-35. PubMed ID: 17949412
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase.
    Golias T; Kery M; Radenkovic S; Papandreou I
    Int J Cancer; 2019 Feb; 144(4):674-686. PubMed ID: 30121950
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
    Jin Y; Cai Q; Shenoy AK; Lim S; Zhang Y; Charles S; Tarrash M; Fu X; Kamarajugadda S; Trevino JG; Tan M; Lu J
    Oncotarget; 2016 May; 7(18):25113-24. PubMed ID: 26848621
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.
    Holness MJ; Sugden MC
    Biochem Soc Trans; 2003 Dec; 31(Pt 6):1143-51. PubMed ID: 14641014
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.
    McFate T; Mohyeldin A; Lu H; Thakar J; Henriques J; Halim ND; Wu H; Schell MJ; Tsang TM; Teahan O; Zhou S; Califano JA; Jeoung NH; Harris RA; Verma A
    J Biol Chem; 2008 Aug; 283(33):22700-8. PubMed ID: 18541534
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of Pyruvate Dehydrogenase Kinase as a Therapeutic Strategy against Cancer.
    Sradhanjali S; Reddy MM
    Curr Top Med Chem; 2018; 18(6):444-453. PubMed ID: 29788890
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation.
    Gan L; Yang Y; Liang Z; Zhang M; He Y; Zhang SL
    Eur J Med Chem; 2024 Jan; 264():116008. PubMed ID: 38056298
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reprogramming of aerobic glycolysis in non-transformed mouse liver with pyruvate dehydrogenase complex deficiency.
    Patel MS; Mahmood S; Jung J; Rideout TC
    Physiol Rep; 2021 Jan; 9(1):e14684. PubMed ID: 33400855
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.