BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 25871734)

  • 1. Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1.
    Kawarski M; Hagerman TK; Karver CE
    Chem Biol Drug Des; 2015 Nov; 86(5):1049-54. PubMed ID: 25871734
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases.
    Kent CR; Bryja M; Gustafson HA; Kawarski MY; Lenti G; Pierce EN; Knopp RC; Ceja V; Pati B; Walters DE; Karver CE
    Bioorg Med Chem Lett; 2016 Nov; 26(22):5476-5480. PubMed ID: 27777011
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-Based Light-Up Probe.
    Lin H; Yang WQ; Ye Z; Zhang CJ
    Chembiochem; 2019 May; 20(10):1292-1296. PubMed ID: 30648790
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC).
    Qian L; Zhang CJ; Wu J; Yao SQ
    Chemistry; 2017 Jan; 23(2):360-369. PubMed ID: 27882694
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
    Flygare JA; Arkin MR
    Curr Top Med Chem; 2014; 14(3):319-25. PubMed ID: 24283214
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small Molecule Active Site Directed Tools for Studying Human Caspases.
    Poreba M; Szalek A; Kasperkiewicz P; Rut W; Salvesen GS; Drag M
    Chem Rev; 2015 Nov; 115(22):12546-629. PubMed ID: 26551511
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of Allosteric Inhibitors against Active Caspase-6.
    Tubeleviciute-Aydin A; Beautrait A; Lynham J; Sharma G; Gorelik A; Deny LJ; Soya N; Lukacs GL; Nagar B; Marinier A; LeBlanc AC
    Sci Rep; 2019 Apr; 9(1):5504. PubMed ID: 30940883
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Small-molecule procaspase activators identified using fluorescence polarization.
    Vickers CJ; González-Páez GE; Umotoy JC; Cayanan-Garrett C; Brown SJ; Wolan DW
    Chembiochem; 2013 Aug; 14(12):1419-22. PubMed ID: 23836614
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Small diverse antioxidant functionalities for oxidative stress disease drug discovery.
    Sikazwe D; Grillo A; Ramsinghani S; Davis J; McQuiston K; Ablordeppey SY
    Mini Rev Med Chem; 2012 Jul; 12(8):768-74. PubMed ID: 22512567
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors.
    Patel S; Modi P; Ranjan V; Chhabria M
    Bioorg Chem; 2018 Aug; 78():258-268. PubMed ID: 29614437
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.
    Smith CE; Soti S; Jones TA; Nakagawa A; Xue D; Yin H
    Cell Chem Biol; 2017 Mar; 24(3):281-292. PubMed ID: 28238723
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.
    Zhu Q; Gao L; Chen Z; Zheng S; Shu H; Li J; Jiang H; Liu S
    Eur J Med Chem; 2012 Aug; 54():232-8. PubMed ID: 22652225
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.
    Mittapalli GK; Jackson A; Zhao F; Lee H; Chow S; McKelvy J; Wong-Staal F; Macdonald JE
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6852-5. PubMed ID: 21978675
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
    Fournier JF; Clary L; Chambon S; Dumais L; Harris CS; Millois C; Pierre R; Talano S; Thoreau É; Aubert J; Aurelly M; Bouix-Peter C; Brethon A; Chantalat L; Christin O; Comino C; El-Bazbouz G; Ghilini AL; Isabet T; Lardy C; Luzy AP; Mathieu C; Mebrouk K; Orfila D; Pascau J; Reverse K; Roche D; Rodeschini V; Hennequin LF
    J Med Chem; 2018 May; 61(9):4030-4051. PubMed ID: 29648825
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles.
    Elías-Rodríguez P; Moreno-Clavijo E; Carmona AT; Moreno-Vargas AJ; Robina I
    Org Biomol Chem; 2014 Aug; 12(31):5898-904. PubMed ID: 24984102
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 6-C-methyl flavonoids isolated from Pinus densata inhibit the proliferation and promote the apoptosis of the HL-60 human promyelocytic leukaemia cell line.
    Yue R; Li B; Shen Y; Zeng H; Li B; Yuan H; He Y; Shan L; Zhang W
    Planta Med; 2013 Aug; 79(12):1024-30. PubMed ID: 23877923
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.
    Wu L; Lu M; Yan Z; Tang X; Sun B; Liu W; Zhou H; Yang C
    Bioorg Med Chem; 2014 Apr; 22(8):2416-26. PubMed ID: 24656804
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Applying caspase-1 inhibitors for inflammasome assays in human whole blood.
    Lipinska K; Malone KE; Moerland M; Kluft C
    J Immunol Methods; 2014 Sep; 411():66-9. PubMed ID: 24925806
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Heterocyclic cellular lipid peroxidation inhibitors inspired by the marine antioxidant barettin.
    Labrière C; Andersen JH; Albrigtsen M; Hansen JH; Svenson J
    Bioorg Chem; 2019 Mar; 84():106-114. PubMed ID: 30500520
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Blockage of caspase-1 activation ameliorates bone marrow inflammation in mice after hematopoietic stem cell transplantation.
    Qiao J; Wu J; Li Y; Xia Y; Chu P; Qi K; Yan Z; Yao H; Liu Y; Xu K; Zeng L
    Clin Immunol; 2016 Jan; 162():84-90. PubMed ID: 26639193
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.