BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 25915439)

  • 1. Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?
    Geschwindner S; Ulander J; Johansson P
    J Med Chem; 2015 Aug; 58(16):6321-35. PubMed ID: 25915439
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A look at ligand binding thermodynamics in drug discovery.
    Claveria-Gimeno R; Vega S; Abian O; Velazquez-Campoy A
    Expert Opin Drug Discov; 2017 Apr; 12(4):363-377. PubMed ID: 28276703
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
    Meanwell NA
    Chem Res Toxicol; 2011 Sep; 24(9):1420-56. PubMed ID: 21790149
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Water networks contribute to enthalpy/entropy compensation in protein-ligand binding.
    Breiten B; Lockett MR; Sherman W; Fujita S; Al-Sayah M; Lange H; Bowers CM; Heroux A; Krilov G; Whitesides GM
    J Am Chem Soc; 2013 Oct; 135(41):15579-84. PubMed ID: 24044696
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enthalpy-entropy compensation: the role of solvation.
    Dragan AI; Read CM; Crane-Robinson C
    Eur Biophys J; 2017 May; 46(4):301-308. PubMed ID: 27796417
    [TBL] [Abstract][Full Text] [Related]  

  • 6. [Rational fragment-design method based on a thermodynamic analysis].
    Tsumoto K; Ui M
    Yakugaku Zasshi; 2009 Nov; 129(11):1311-7. PubMed ID: 19881202
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Computation of binding energies including their enthalpy and entropy components for protein-ligand complexes using support vector machines.
    Koppisetty CA; Frank M; Kemp GJ; Nyholm PG
    J Chem Inf Model; 2013 Oct; 53(10):2559-70. PubMed ID: 24050538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H(1)-receptor.
    Wittmann HJ; Seifert R; Strasser A
    Mol Pharmacol; 2009 Jul; 76(1):25-37. PubMed ID: 19346300
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Enthalpy-entropy Compensation Phenomenon. Limitations for the Use of Some Basic Thermodynamic Equations.
    Khrapunov S
    Curr Protein Pept Sci; 2018; 19(11):1088-1091. PubMed ID: 29779476
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Influence of neighboring groups on the thermodynamics of hydrophobic binding: an added complex facet to the hydrophobic effect.
    Nasief NN; Hangauer D
    J Med Chem; 2014 Mar; 57(6):2315-33. PubMed ID: 24479949
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thermodynamics guided lead discovery and optimization.
    Ferenczy GG; Keserũ GM
    Drug Discov Today; 2010 Nov; 15(21-22):919-32. PubMed ID: 20801227
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thermodynamic profiling for fragment-based lead discovery and optimization.
    Ferenczy GG; Keserű GM
    Expert Opin Drug Discov; 2020 Jan; 15(1):117-129. PubMed ID: 31741402
    [No Abstract]   [Full Text] [Related]  

  • 13. Enthalpy-entropy contributions to salt and osmolyte effects on molecular-scale hydrophobic hydration and interactions.
    Athawale MV; Sarupria S; Garde S
    J Phys Chem B; 2008 May; 112(18):5661-70. PubMed ID: 18447346
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.
    Portman KL; Long J; Carr S; Briand L; Winzor DJ; Searle MS; Scott DJ
    Biochemistry; 2014 Apr; 53(14):2371-9. PubMed ID: 24665925
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enthalpy-entropy compensation and cooperativity as thermodynamic epiphenomena of structural flexibility in ligand-receptor interactions.
    Ferrante A; Gorski J
    J Mol Biol; 2012 Apr; 417(5):454-67. PubMed ID: 22342886
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The use of thermodynamic and kinetic data in drug discovery: decisive insight or increasing the puzzlement?
    Klebe G
    ChemMedChem; 2015 Feb; 10(2):229-31. PubMed ID: 25537429
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PDBcal: a comprehensive dataset for receptor-ligand interactions with three-dimensional structures and binding thermodynamics from isothermal titration calorimetry.
    Li L; Dantzer JJ; Nowacki J; O'Callaghan BJ; Meroueh SO
    Chem Biol Drug Des; 2008 Jun; 71(6):529-32. PubMed ID: 18482338
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.
    Olsson TS; Williams MA; Pitt WR; Ladbury JE
    J Mol Biol; 2008 Dec; 384(4):1002-17. PubMed ID: 18930735
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Energetic and entropic factors determining binding affinity in protein-ligand complexes.
    Klebe G; Böhm HJ
    J Recept Signal Transduct Res; 1997; 17(1-3):459-73. PubMed ID: 9029508
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.
    Hishinuma S; Sugawara K; Uesawa Y; Fukui H; Shoji M
    Biochem Pharmacol; 2014 Sep; 91(2):231-41. PubMed ID: 25065879
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.