BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 25915781)

  • 1. First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
    Eng WS; Hocková D; Špaček P; Janeba Z; West NP; Woods K; Naesens LM; Keough DT; Guddat LW
    J Med Chem; 2015 Jun; 58(11):4822-38. PubMed ID: 25915781
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
    Eng WS; Rejman D; Pohl R; West NP; Woods K; Naesens LMJ; Keough DT; Guddat LW
    Eur J Med Chem; 2018 Nov; 159():10-22. PubMed ID: 30265958
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability.
    Knejzlík Z; Herkommerová K; Hocková D; Pichová I
    J Bacteriol; 2020 Feb; 202(5):. PubMed ID: 31818925
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
    Keough DT; Špaček P; Hocková D; Tichý T; Vrbková S; Slavětínská L; Janeba Z; Naesens L; Edstein MD; Chavchich M; Wang TH; de Jersey J; Guddat LW
    J Med Chem; 2013 Mar; 56(6):2513-26. PubMed ID: 23448281
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
    Keough DT; Hocková D; Rejman D; Spaček P; Vrbková S; Krečmerová M; Eng WS; Jans H; West NP; Naesens LM; de Jersey J; Guddat LW
    J Med Chem; 2013 Sep; 56(17):6967-84. PubMed ID: 23927482
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.
    Terán D; Hocková D; Česnek M; Zíková A; Naesens L; Keough DT; Guddat LW
    Sci Rep; 2016 Oct; 6():35894. PubMed ID: 27786284
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
    Keough DT; Hocková D; Janeba Z; Wang TH; Naesens L; Edstein MD; Chavchich M; Guddat LW
    J Med Chem; 2015 Jan; 58(2):827-46. PubMed ID: 25494538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
    Kaiser MM; Hocková D; Wang TH; Dračínský M; Poštová-Slavětínská L; Procházková E; Edstein MD; Chavchich M; Keough DT; Guddat LW; Janeba Z
    ChemMedChem; 2015 Oct; 10(10):1707-23. PubMed ID: 26368337
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
    Hocková D; Janeba Z; Naesens L; Edstein MD; Chavchich M; Keough DT; Guddat LW
    Bioorg Med Chem; 2015 Sep; 23(17):5502-10. PubMed ID: 26275679
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
    Hazleton KZ; Ho MC; Cassera MB; Clinch K; Crump DR; Rosario I; Merino EF; Almo SC; Tyler PC; Schramm VL
    Chem Biol; 2012 Jun; 19(6):721-30. PubMed ID: 22726686
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
    Tizón L; Otero JM; Prazeres VF; Llamas-Saiz AL; Fox GC; van Raaij MJ; Lamb H; Hawkins AR; Ainsa JA; Castedo L; González-Bello C
    J Med Chem; 2011 Sep; 54(17):6063-84. PubMed ID: 21780742
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis.
    Zhang N; Gong X; Lu M; Chen X; Qin X; Ge H
    J Struct Biol; 2016 Jun; 194(3):311-6. PubMed ID: 26968365
    [TBL] [Abstract][Full Text] [Related]  

  • 13.
    Keough DT; Wun SJ; Baszczyňski O; Eng WS; Špaček P; Panjikar S; Naesens L; Pohl R; Rejman D; Hocková D; Ferrero RL; Guddat LW
    J Med Chem; 2021 May; 64(9):5710-5729. PubMed ID: 33891818
    [No Abstract]   [Full Text] [Related]  

  • 14. Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
    Klejch T; Keough DT; Chavchich M; Travis J; Skácel J; Pohl R; Janeba Z; Edstein MD; Avery VM; Guddat LW; Hocková D
    Eur J Med Chem; 2019 Dec; 183():111667. PubMed ID: 31536893
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.
    Eng WS; Keough DT; Hockova D; Winzor DJ; Guddat LW
    Biochimie; 2017 Apr; 135():6-14. PubMed ID: 28082125
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
    Keough DT; Hocková D; Holý A; Naesens LM; Skinner-Adams TS; Jersey Jd; Guddat LW
    J Med Chem; 2009 Jul; 52(14):4391-9. PubMed ID: 19527031
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
    Doleželová E; Terán D; Gahura O; Kotrbová Z; Procházková M; Keough D; Špaček P; Hocková D; Guddat L; Zíková A
    PLoS Negl Trop Dis; 2018 Feb; 12(2):e0006301. PubMed ID: 29481567
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.
    Biazus G; Schneider CZ; Palma MS; Basso LA; Santos DS
    Protein Expr Purif; 2009 Aug; 66(2):185-90. PubMed ID: 19362594
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.
    Kaiser MM; Baszczyňski O; Hocková D; Poštová-Slavětínská L; Dračínský M; Keough DT; Guddat LW; Janeba Z
    ChemMedChem; 2017 Jul; 12(14):1133-1141. PubMed ID: 28628279
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferases.
    Moynié L; Giraud MF; Breton A; Boissier F; Daignan-Fornier B; Dautant A
    Protein Sci; 2012 Aug; 21(8):1185-96. PubMed ID: 22610485
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.