BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 25917861)

  • 1. Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering.
    Bai J; Zhou Y; Chen Q; Yang Q; Yang J
    Chembiochem; 2015 May; 16(8):1219-25. PubMed ID: 25917861
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA.
    Yang J; Zhan J; Bai J; Liu P; Xue Y; Yang Q
    Biotechnol Lett; 2013 Oct; 35(10):1693-700. PubMed ID: 23801116
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
    Race PR; Lovering AL; White SA; Grove JI; Searle PF; Wrighton CW; Hyde EI
    J Mol Biol; 2007 Apr; 368(2):481-92. PubMed ID: 17350040
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis.
    LinWu SW; Wu CA; Peng FC; Wang AH
    Biochem Pharmacol; 2012 Jun; 83(12):1690-9. PubMed ID: 22445794
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
    Jarrom D; Jaberipour M; Guise CP; Daff S; White SA; Searle PF; Hyde EI
    Biochemistry; 2009 Aug; 48(32):7665-72. PubMed ID: 19580253
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biochemical characterization of trinitrotoluene transforming oxygen-insensitive nitroreductases from Clostridium acetobutylicum ATCC 824.
    Kutty R; Bennett GN
    Arch Microbiol; 2005 Nov; 184(3):158-67. PubMed ID: 16187099
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characteristics of major Escherichia coli reductases involved in aerobic nitro and azo reduction.
    Mercier C; Chalansonnet V; Orenga S; Gilbert C
    J Appl Microbiol; 2013 Oct; 115(4):1012-22. PubMed ID: 23795903
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
    Johansson E; Parkinson GN; Denny WA; Neidle S
    J Med Chem; 2003 Sep; 46(19):4009-20. PubMed ID: 12954054
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism of CB1954 reduction by Escherichia coli nitroreductase.
    Christofferson A; Wilkie J
    Biochem Soc Trans; 2009 Apr; 37(Pt 2):413-8. PubMed ID: 19290872
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
    Copp JN; Mowday AM; Williams EM; Guise CP; Ashoorzadeh A; Sharrock AV; Flanagan JU; Smaill JB; Patterson AV; Ackerley DF
    Cell Chem Biol; 2017 Mar; 24(3):391-403. PubMed ID: 28262557
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties.
    Valle A; Le Borgne S; Bolívar J; Cabrera G; Cantero D
    Appl Microbiol Biotechnol; 2012 Apr; 94(1):163-71. PubMed ID: 22173483
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues.
    Hall KR; Robins KJ; Williams EM; Rich MH; Calcott MJ; Copp JN; Little RF; Schwörer R; Evans GB; Patrick WM; Ackerley DF
    Elife; 2020 Nov; 9():. PubMed ID: 33185191
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Surface orientation control of site-specifically immobilized nitro-reductase (NfsB).
    Shen L; Schroeder M; Ogorzalek TL; Yang P; Wu FG; Marsh EN; Chen Z
    Langmuir; 2014 May; 30(20):5930-8. PubMed ID: 24807676
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure and Dynamics of Three
    Day MA; Christofferson AJ; Anderson JLR; Vass SO; Evans A; Searle PF; White SA; Hyde EI
    Int J Mol Sci; 2023 Mar; 24(6):. PubMed ID: 36983061
    [No Abstract]   [Full Text] [Related]  

  • 15. A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation.
    Williams EM; Sharrock AV; Rylott EL; Bruce NC; MacKichan JK; Ackerley DF
    Biotechnol Lett; 2019 Oct; 41(10):1155-1162. PubMed ID: 31392514
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Engineering
    Williams EM; Rich MH; Mowday AM; Ashoorzadeh A; Copp JN; Guise CP; Anderson RF; Flanagan JU; Smaill JB; Patterson AV; Ackerley DF
    Biochemistry; 2019 Sep; 58(35):3700-3710. PubMed ID: 31403283
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
    Day MA; Jarrom D; Christofferson AJ; Graziano AE; Anderson JLR; Searle PF; Hyde EI; White SA
    Biochem J; 2021 Jul; 478(13):2601-2617. PubMed ID: 34142705
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.
    Rich MH; Sharrock AV; Hall KR; Ackerley DF; MacKichan JK
    Biotechnol Lett; 2018 Feb; 40(2):359-367. PubMed ID: 29147875
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution.
    Zenno S; Koike H; Tanokura M; Saigo K
    J Bacteriol; 1996 Aug; 178(15):4731-3. PubMed ID: 8755909
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
    Jiang Y; Han J; Yu C; Vass SO; Searle PF; Browne P; Knox RJ; Hu L
    J Med Chem; 2006 Jul; 49(14):4333-43. PubMed ID: 16821793
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.