These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

783 related articles for article (PubMed ID: 25921072)

  • 1. The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.
    Duzdevich D; Warner MD; Ticau S; Ivica NA; Bell SP; Greene EC
    Mol Cell; 2015 May; 58(3):483-94. PubMed ID: 25921072
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DNA replication origins retain mobile licensing proteins.
    Sánchez H; McCluskey K; van Laar T; van Veen E; Asscher FM; Solano B; Diffley JFX; Dekker NH
    Nat Commun; 2021 Mar; 12(1):1908. PubMed ID: 33772005
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A helicase-tethered ORC flip enables bidirectional helicase loading.
    Gupta S; Friedman LJ; Gelles J; Bell SP
    Elife; 2021 Dec; 10():. PubMed ID: 34882090
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
    Feng X; Noguchi Y; Barbon M; Stillman B; Speck C; Li H
    Nat Commun; 2021 Jun; 12(1):3883. PubMed ID: 34162887
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
    Randell JC; Bowers JL; Rodríguez HK; Bell SP
    Mol Cell; 2006 Jan; 21(1):29-39. PubMed ID: 16387651
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Replication origin-flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence.
    Warner MD; Azmi IF; Kang S; Zhao Y; Bell SP
    J Biol Chem; 2017 Dec; 292(52):21417-21430. PubMed ID: 29074622
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing.
    Zhang A; Friedman LJ; Gelles J; Bell SP
    Proc Natl Acad Sci U S A; 2023 Jul; 120(30):e2305556120. PubMed ID: 37463200
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.
    Evrin C; Fernández-Cid A; Riera A; Zech J; Clarke P; Herrera MC; Tognetti S; Lurz R; Speck C
    Nucleic Acids Res; 2014 Feb; 42(4):2257-69. PubMed ID: 24234446
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.
    Fernández-Cid A; Riera A; Tognetti S; Herrera MC; Samel S; Evrin C; Winkler C; Gardenal E; Uhle S; Speck C
    Mol Cell; 2013 May; 50(4):577-88. PubMed ID: 23603117
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing.
    Reuter LM; Khadayate SP; Mossler A; Liebl K; Faull SV; Karimi MM; Speck C
    Nat Commun; 2024 Aug; 15(1):7306. PubMed ID: 39181881
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing.
    Amasino AL; Gupta S; Friedman LJ; Gelles J; Bell SP
    Proc Natl Acad Sci U S A; 2023 Jul; 120(29):e2221484120. PubMed ID: 37428921
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
    Yuan Z; Riera A; Bai L; Sun J; Nandi S; Spanos C; Chen ZA; Barbon M; Rappsilber J; Stillman B; Speck C; Li H
    Nat Struct Mol Biol; 2017 Mar; 24(3):316-324. PubMed ID: 28191893
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading.
    Ticau S; Friedman LJ; Ivica NA; Gelles J; Bell SP
    Cell; 2015 Apr; 161(3):513-525. PubMed ID: 25892223
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.
    Evrin C; Fernández-Cid A; Zech J; Herrera MC; Riera A; Clarke P; Brill S; Lurz R; Speck C
    Nucleic Acids Res; 2013 Mar; 41(5):3162-72. PubMed ID: 23376927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer.
    Miyazawa-Onami M; Araki H; Tanaka S
    EMBO Rep; 2017 Oct; 18(10):1752-1761. PubMed ID: 28818838
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
    Remus D; Beuron F; Tolun G; Griffith JD; Morris EP; Diffley JF
    Cell; 2009 Nov; 139(4):719-30. PubMed ID: 19896182
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
    Chen S; de Vries MA; Bell SP
    Genes Dev; 2007 Nov; 21(22):2897-907. PubMed ID: 18006685
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
    Yuan Z; Schneider S; Dodd T; Riera A; Bai L; Yan C; Magdalou I; Ivanov I; Stillman B; Li H; Speck C
    Proc Natl Acad Sci U S A; 2020 Jul; 117(30):17747-17756. PubMed ID: 32669428
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.
    Takara TJ; Bell SP
    EMBO J; 2011 Nov; 30(24):4885-96. PubMed ID: 22045335
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.
    Samel SA; Fernández-Cid A; Sun J; Riera A; Tognetti S; Herrera MC; Li H; Speck C
    Genes Dev; 2014 Aug; 28(15):1653-66. PubMed ID: 25085418
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 40.