BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1002 related articles for article (PubMed ID: 25930235)

  • 1. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
    Shibuya Y; Niu Z; Bryleva EY; Harris BT; Murphy SR; Kheirollah A; Bowen ZD; Chang CCY; Chang TY
    Neurobiol Aging; 2015 Jul; 36(7):2248-2259. PubMed ID: 25930235
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.
    Murphy SR; Chang CC; Dogbevia G; Bryleva EY; Bowen Z; Hasan MT; Chang TY
    Mol Ther; 2013 Aug; 21(8):1497-506. PubMed ID: 23774792
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
    Zhang ZH; Wu QY; Zheng R; Chen C; Chen Y; Liu Q; Hoffmann PR; Ni JZ; Song GL
    J Neurosci; 2017 Mar; 37(9):2449-2462. PubMed ID: 28137967
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
    Huttunen HJ; Havas D; Peach C; Barren C; Duller S; Xia W; Frosch MP; Hutter-Paier B; Windisch M; Kovacs DM
    J Neuropathol Exp Neurol; 2010 Aug; 69(8):777-88. PubMed ID: 20613640
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
    Shibuya Y; Chang CC; Huang LH; Bryleva EY; Chang TY
    J Neurosci; 2014 Oct; 34(43):14484-501. PubMed ID: 25339759
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
    Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
    Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
    Chen Y; Zhu L; Ji L; Yang Y; Lu L; Wang X; Zhou G
    Med Sci Monit; 2018 Dec; 24():9007-9018. PubMed ID: 30541014
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.
    Onishi T; Iwashita H; Uno Y; Kunitomo J; Saitoh M; Kimura E; Fujita H; Uchiyama N; Kori M; Takizawa M
    J Neurochem; 2011 Dec; 119(6):1330-40. PubMed ID: 21992552
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
    Bryleva EY; Rogers MA; Chang CC; Buen F; Harris BT; Rousselet E; Seidah NG; Oddo S; LaFerla FM; Spencer TA; Hickey WF; Chang TY
    Proc Natl Acad Sci U S A; 2010 Feb; 107(7):3081-6. PubMed ID: 20133765
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.
    Shibuya Y; Chang CC; Chang TY
    Future Med Chem; 2015; 7(18):2451-67. PubMed ID: 26669800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles.
    Chu J; Lauretti E; Craige CP; Praticò D
    J Alzheimers Dis; 2014; 41(3):729-37. PubMed ID: 24662099
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
    España J; Giménez-Llort L; Valero J; Miñano A; Rábano A; Rodriguez-Alvarez J; LaFerla FM; Saura CA
    Biol Psychiatry; 2010 Mar; 67(6):513-21. PubMed ID: 19664757
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.
    Dobarro M; Gerenu G; Ramírez MJ
    Int J Neuropsychopharmacol; 2013 Nov; 16(10):2245-57. PubMed ID: 23768694
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.
    Gibbons GS; Banks RA; Kim B; Xu H; Changolkar L; Leight SN; Riddle DM; Li C; Gathagan RJ; Brown HJ; Zhang B; Trojanowski JQ; Lee VM
    J Neurosci; 2017 Nov; 37(47):11485-11494. PubMed ID: 28986461
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.
    Imamura T; Yanagihara YT; Ohyagi Y; Nakamura N; Iinuma KM; Yamasaki R; Asai H; Maeda M; Murakami K; Irie K; Kira JI
    Neurobiol Dis; 2020 Apr; 137():104739. PubMed ID: 31927145
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
    Clausen A; Xu X; Bi X; Baudry M
    J Alzheimers Dis; 2012; 30(1):183-208. PubMed ID: 22406441
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
    Song JX; Malampati S; Zeng Y; Durairajan SSK; Yang CB; Tong BC; Iyaswamy A; Shang WB; Sreenivasmurthy SG; Zhu Z; Cheung KH; Lu JH; Tang C; Xu N; Li M
    Aging Cell; 2020 Feb; 19(2):e13069. PubMed ID: 31858697
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alzheimer's disease pathological lesions activate the spleen tyrosine kinase.
    Schweig JE; Yao H; Beaulieu-Abdelahad D; Ait-Ghezala G; Mouzon B; Crawford F; Mullan M; Paris D
    Acta Neuropathol Commun; 2017 Sep; 5(1):69. PubMed ID: 28877763
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AβPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimer's Disease.
    Bielarczyk H; Jankowska-Kulawy A; Höfling C; Ronowska A; Gul-Hinc S; Roßner S; Schliebs R; Pawelczyk T; Szutowicz A
    J Alzheimers Dis; 2015; 48(4):1083-94. PubMed ID: 26402099
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.
    Hopp SC; Lin Y; Oakley D; Roe AD; DeVos SL; Hanlon D; Hyman BT
    J Neuroinflammation; 2018 Sep; 15(1):269. PubMed ID: 30227881
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 51.