289 related articles for article (PubMed ID: 25931013)
1. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.
Rivers A; Vaitkus K; Ruiz MA; Ibanez V; Jagadeeswaran R; Kouznetsova T; DeSimone J; Lavelle D
Exp Hematol; 2015 Jul; 43(7):546-53.e1-3. PubMed ID: 25931013
[TBL] [Abstract][Full Text] [Related]
2. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).
Rivers A; Vaitkus K; Ibanez V; Ruiz MA; Jagadeeswaran R; Saunthararajah Y; Cui S; Engel JD; DeSimone J; Lavelle D
Haematologica; 2016 Jun; 101(6):688-97. PubMed ID: 26858356
[TBL] [Abstract][Full Text] [Related]
3. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.
Rivers A; Vaitkus K; Jagadeeswaran R; Ruiz MA; Ibanez V; Ciceri F; Cavalcanti F; Molokie RE; Saunthararajah Y; Engel JD; DeSimone J; Lavelle D
Exp Hematol; 2018 Nov; 67():60-64.e2. PubMed ID: 30125603
[TBL] [Abstract][Full Text] [Related]
4. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.
Shi L; Cui S; Engel JD; Tanabe O
Nat Med; 2013 Mar; 19(3):291-4. PubMed ID: 23416702
[TBL] [Abstract][Full Text] [Related]
5. Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.
Dulmovits BM; Appiah-Kubi AO; Papoin J; Hale J; He M; Al-Abed Y; Didier S; Gould M; Husain-Krautter S; Singh SA; Chan KW; Vlachos A; Allen SL; Taylor N; Marambaud P; An X; Gallagher PG; Mohandas N; Lipton JM; Liu JM; Blanc L
Blood; 2016 Mar; 127(11):1481-92. PubMed ID: 26679864
[TBL] [Abstract][Full Text] [Related]
6. Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.
Chin J; Singh M; Banzon V; Vaitkus K; Ibanez V; Kouznetsova T; Mahmud N; DeSimone J; Lavelle D
Exp Hematol; 2009 Oct; 37(10):1131-42. PubMed ID: 19576949
[TBL] [Abstract][Full Text] [Related]
7. Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.
Ruiz MA; Rivers A; Ibanez V; Vaitkus K; Mahmud N; DeSimone J; Lavelle D
Epigenetics; 2015; 10(5):397-407. PubMed ID: 25932923
[TBL] [Abstract][Full Text] [Related]
8. Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.
Ronzoni L; Sonzogni L; Fossati G; Modena D; Trombetta E; Porretti L; Cappellini MD
Br J Haematol; 2014 Jun; 165(5):714-21. PubMed ID: 24606390
[TBL] [Abstract][Full Text] [Related]
9. Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis).
Ibanez V; Vaitkus K; Ruiz MA; Lei Z; Maienschein-Cline M; Arbieva Z; Lavelle D
PLoS One; 2023; 18(12):e0289860. PubMed ID: 38134183
[TBL] [Abstract][Full Text] [Related]
10. Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.
Pecoraro A; Troia A; Calzolari R; Scazzone C; Rigano P; Martorana A; Sacco M; Maggio A; Di Marzo R
Hemoglobin; 2015; 39(4):225-9. PubMed ID: 26016899
[TBL] [Abstract][Full Text] [Related]
11. Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data.
Rivers A; Jagadeeswaran R; Lavelle D
Am J Physiol Regul Integr Comp Physiol; 2018 Oct; 315(4):R840-R847. PubMed ID: 30067082
[TBL] [Abstract][Full Text] [Related]
12. Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF.
Ibanez V; Vaitkus K; Zhang X; Ramasamy J; Rivers AE; Saunthararajah Y; Molokie R; Lavelle D
Blood Adv; 2023 Aug; 7(15):3891-3902. PubMed ID: 36884303
[TBL] [Abstract][Full Text] [Related]
13. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
Zhang Y; Paikari A; Sumazin P; Ginter Summarell CC; Crosby JR; Boerwinkle E; Weiss MJ; Sheehan VA
Blood; 2018 Jul; 132(3):321-333. PubMed ID: 29884740
[TBL] [Abstract][Full Text] [Related]
14. Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.
Chou YC; Chen RL; Lai ZS; Song JS; Chao YS; Shen CK
Mol Cell Biol; 2015 Jul; 35(14):2541-53. PubMed ID: 25986606
[TBL] [Abstract][Full Text] [Related]
15. Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid.
Johnson J; Hunter R; McElveen R; Qian XH; Baliga BS; Pace BS
Cell Mol Biol (Noisy-le-grand); 2005 Sep; 51(2):229-38. PubMed ID: 16171558
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.
Krivega I; Byrnes C; de Vasconcellos JF; Lee YT; Kaushal M; Dean A; Miller JL
Blood; 2015 Jul; 126(5):665-72. PubMed ID: 25979948
[TBL] [Abstract][Full Text] [Related]
17. Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.
Li H; Xie W; Gore ER; Montoute MN; Bee WT; Zappacosta F; Zeng X; Wu Z; Kallal L; Ames RS; Pope AJ; Benowitz A; Erickson-Miller CL
J Biomol Screen; 2013 Dec; 18(10):1212-22. PubMed ID: 24163393
[TBL] [Abstract][Full Text] [Related]
18. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells.
Aimola IA; Inuwa HM; Nok AJ; Mamman AI; Bieker JJ
Eur J Pharmacol; 2016 Apr; 776():9-18. PubMed ID: 26879870
[TBL] [Abstract][Full Text] [Related]
19. Hydroxyurea responses and fetal hemoglobin induction in beta-thalassemia/HbE patients' peripheral blood erythroid cell culture.
Watanapokasin R; Sanmund D; Winichagoon P; Muta K; Fucharoen S
Ann Hematol; 2006 Mar; 85(3):164-9. PubMed ID: 16389564
[TBL] [Abstract][Full Text] [Related]
20. Multiple physical stresses induce γ-globin gene expression and fetal hemoglobin production in erythroid cells.
Schaeffer EK; West RJ; Conine SJ; Lowrey CH
Blood Cells Mol Dis; 2014 Apr; 52(4):214-24. PubMed ID: 24314748
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
