BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 25948712)

  • 1. Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Drug Metab Dispos; 2015 Jul; 43(7):1119-22. PubMed ID: 25948712
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Biopharm Drug Dispos; 2015 Dec; 36(9):636-43. PubMed ID: 26348733
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.
    Iwasaki K; Kitsugi Y; Ikeda K; Yoshikawa T; Hosaka S; Uehara S; Uno Y; Utoh M; Yamazaki H
    Biopharm Drug Dispos; 2016 Sep; 37(6):379-83. PubMed ID: 27417918
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors.
    Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Biopharm Drug Dispos; 2016 Jul; 37(5):310-3. PubMed ID: 26581561
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles.
    Emoto C; Yoda N; Uno Y; Iwasaki K; Umehara K; Kashiyama E; Yamazaki H
    Curr Drug Metab; 2013 Feb; 14(2):239-52. PubMed ID: 22963393
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models.
    Utoh M; Miura T; Kusama T; Uehara S; Shimizu M; Uno Y; Yamazaki H
    Biopharm Drug Dispos; 2017 Oct; 38(7):439-442. PubMed ID: 28608515
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.
    Hosaka S; Murayama N; Satsukawa M; Shimizu M; Uehara S; Fujino H; Iwasaki K; Iwano S; Uno Y; Yamazaki H
    Drug Metab Dispos; 2015 Jan; 43(1):27-33. PubMed ID: 25318994
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.
    Uno Y; Uehara S; Yamazaki H
    Biochem Pharmacol; 2018 Jul; 153():184-195. PubMed ID: 29277691
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.
    Uno Y; Matsushita A; Murayama N; Yamazaki H
    Drug Metab Pharmacokinet; 2015 Feb; 30(1):130-2. PubMed ID: 25760542
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization.
    Mitsuda M; Iwasaki M; Asahi S
    J Biochem; 2006 May; 139(5):865-72. PubMed ID: 16751594
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.
    Yoda N; Emoto C; Date S; Kondo S; Miyake M; Nakazato S; Umehara K; Kashiyama E
    Xenobiotica; 2012 Aug; 42(8):719-30. PubMed ID: 22324396
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.
    Uno Y; Uehara S; Yamazaki H
    Biochem Pharmacol; 2016 Dec; 121():1-7. PubMed ID: 27318253
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole.
    Uno Y; Murayama N; Yamazaki H
    Drug Metab Dispos; 2024 Feb; 52(3):266-273. PubMed ID: 38123944
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Diclofenac hydroxylation in monkeys: efficiency, regioselectivity, and response to inhibitors.
    Tang C; Fang Y; Booth-Genthe C; Kuo Y; Kuduk SD; Rushmore TH; Carr BA
    Biochem Pharmacol; 2007 Mar; 73(6):880-90. PubMed ID: 17223083
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.
    Uehara S; Uno Y; Inoue T; Kawano M; Shimizu M; Toda A; Utoh M; Sasaki E; Yamazaki H
    Drug Metab Dispos; 2015 Oct; 43(10):1408-16. PubMed ID: 26228688
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques.
    Uno Y; Uehara S; Murayama N; Yamazaki H
    Chem Res Toxicol; 2018 Dec; 31(12):1373-1381. PubMed ID: 30412386
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
    Uno Y; Fujino H; Kito G; Kamataki T; Nagata R
    Mol Pharmacol; 2006 Aug; 70(2):477-86. PubMed ID: 16648389
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5'-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography-Tandem Mass Spectrometry.
    Lee B; Ji HK; Lee T; Liu KH
    Drug Metab Dispos; 2015 Jul; 43(7):1137-46. PubMed ID: 25904760
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey.
    Uno Y; Uehara S; Kohara S; Iwasaki K; Nagata R; Fukuzaki K; Utoh M; Murayama N; Yamazaki H
    PLoS One; 2011 Feb; 6(2):e16923. PubMed ID: 21347438
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.
    Uno Y; Iwasaki K; Yamazaki H; Nelson DR
    Drug Metab Rev; 2011 Aug; 43(3):346-61. PubMed ID: 21303270
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.