142 related articles for article (PubMed ID: 25965897)
1. New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
Li W; Zheng S; Higgins M; Morra RP; Mendis AT; Chien CW; Ojima I; Mierke DF; Dinkova-Kostova AT; Honda T
J Med Chem; 2015 Jun; 58(11):4738-48. PubMed ID: 25965897
[TBL] [Abstract][Full Text] [Related]
2. Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages.
Lv H; Ren W; Zheng Y; Wang L; Lu G; Yi P; Ci X
Food Funct; 2016 Jan; 7(1):355-63. PubMed ID: 26499342
[TBL] [Abstract][Full Text] [Related]
3. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
Dinkova-Kostova AT; Talalay P; Sharkey J; Zhang Y; Holtzclaw WD; Wang XJ; David E; Schiavoni KH; Finlayson S; Mierke DF; Honda T
J Biol Chem; 2010 Oct; 285(44):33747-55. PubMed ID: 20801881
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
Saito A; Higgins M; Zheng S; Li W; Ojima I; Dinkova-Kostova AT; Honda T
Bioorg Med Chem Lett; 2013 Oct; 23(20):5540-3. PubMed ID: 24018193
[TBL] [Abstract][Full Text] [Related]
5. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Uruno A; Motohashi H
Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
[TBL] [Abstract][Full Text] [Related]
6. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
Zheng S; Santosh Laxmi YR; David E; Dinkova-Kostova AT; Shiavoni KH; Ren Y; Zheng Y; Trevino I; Bumeister R; Ojima I; Wigley WC; Bliska JB; Mierke DF; Honda T
J Med Chem; 2012 May; 55(10):4837-46. PubMed ID: 22533790
[TBL] [Abstract][Full Text] [Related]
7. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Yates MS; Tran QT; Dolan PM; Osburn WO; Shin S; McCulloch CC; Silkworth JB; Taguchi K; Yamamoto M; Williams CR; Liby KT; Sporn MB; Sutter TR; Kensler TW
Carcinogenesis; 2009 Jun; 30(6):1024-31. PubMed ID: 19386581
[TBL] [Abstract][Full Text] [Related]
8. The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.
Copple IM; Goldring CE; Jenkins RE; Chia AJ; Randle LE; Hayes JD; Kitteringham NR; Park BK
Hepatology; 2008 Oct; 48(4):1292-301. PubMed ID: 18785192
[TBL] [Abstract][Full Text] [Related]
9. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT; Liby KT; Stephenson KK; Holtzclaw WD; Gao X; Suh N; Williams C; Risingsong R; Honda T; Gribble GW; Sporn MB; Talalay P
Proc Natl Acad Sci U S A; 2005 Mar; 102(12):4584-9. PubMed ID: 15767573
[TBL] [Abstract][Full Text] [Related]
10. Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell.
Wu A; Yang Z; Huang Y; Yuan H; Lin C; Wang T; Zhao Z; Zhou Y; Zhu C
J Ethnopharmacol; 2020 Aug; 258():112857. PubMed ID: 32298752
[TBL] [Abstract][Full Text] [Related]
11. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M
Mol Cell; 2013 Sep; 51(5):618-31. PubMed ID: 24011591
[TBL] [Abstract][Full Text] [Related]
12. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
He X; Ma Q
J Pharmacol Exp Ther; 2010 Jan; 332(1):66-75. PubMed ID: 19808700
[TBL] [Abstract][Full Text] [Related]
13. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways.
Gan FF; Ling H; Ang X; Reddy SA; Lee SS; Yang H; Tan SH; Hayes JD; Chui WK; Chew EH
Toxicol Appl Pharmacol; 2013 Nov; 272(3):852-62. PubMed ID: 23899529
[TBL] [Abstract][Full Text] [Related]
14. Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway.
Pandurangan AK; Saadatdoust Z; Esa NM; Hamzah H; Ismail A
Biofactors; 2015; 41(1):1-14. PubMed ID: 25545372
[TBL] [Abstract][Full Text] [Related]
15. Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.
Lio CK; Luo JF; Shen XY; Dai Y; Machado J; Xie Y; Yao YD; Yu Y; Liu JX; Yao XS; Luo P; Zhou H
Biochem Pharmacol; 2020 Mar; 173():113639. PubMed ID: 31536727
[TBL] [Abstract][Full Text] [Related]
16. The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Lu MC; Ji JA; Jiang ZY; You QD
Med Res Rev; 2016 Sep; 36(5):924-63. PubMed ID: 27192495
[TBL] [Abstract][Full Text] [Related]
17. Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.
Li B; Abdalrahman A; Lai Y; Janicki JS; Ward KW; Meyer CJ; Wang XL; Tang D; Cui T
Biochem Biophys Res Commun; 2014 Feb; 444(4):555-61. PubMed ID: 24486487
[TBL] [Abstract][Full Text] [Related]
18. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Inami Y; Waguri S; Sakamoto A; Kouno T; Nakada K; Hino O; Watanabe S; Ando J; Iwadate M; Yamamoto M; Lee MS; Tanaka K; Komatsu M
J Cell Biol; 2011 Apr; 193(2):275-84. PubMed ID: 21482715
[TBL] [Abstract][Full Text] [Related]
19. Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-
Wen YL; He Z; Hou DX; Qin S
Oxid Med Cell Longev; 2021; 2021():6631929. PubMed ID: 34545298
[TBL] [Abstract][Full Text] [Related]
20. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
Winkel AF; Engel CK; Margerie D; Kannt A; Szillat H; Glombik H; Kallus C; Ruf S; Güssregen S; Riedel J; Herling AW; von Knethen A; Weigert A; Brüne B; Schmoll D
J Biol Chem; 2015 Nov; 290(47):28446-28455. PubMed ID: 26459563
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
