BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 25981125)

  • 1. Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers.
    Seifert F; Demuth HU; Weichler T; Ludwig HH; Tittmann K; Schilling S
    Bioorg Chem; 2015 Jun; 60():98-101. PubMed ID: 25981125
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.
    Seifert F; Schulz K; Koch B; Manhart S; Demuth HU; Schilling S
    Biochemistry; 2009 Dec; 48(50):11831-3. PubMed ID: 19921850
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
    Schilling S; Lindner C; Koch B; Wermann M; Rahfeld JU; von Bohlen A; Rudolph T; Reuter G; Demuth HU
    Biochemistry; 2007 Sep; 46(38):10921-30. PubMed ID: 17722885
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substrate specificity of glutaminyl cyclases from plants and animals.
    Schilling S; Manhart S; Hoffmann T; Ludwig HH; Wasternack C; Demuth HU
    Biol Chem; 2003 Dec; 384(12):1583-92. PubMed ID: 14719800
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
    Cynis H; Scheel E; Saido TC; Schilling S; Demuth HU
    Biochemistry; 2008 Jul; 47(28):7405-13. PubMed ID: 18570439
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes.
    Wu VW; Dana CM; Iavarone AT; Clark DS; Glass NL
    mBio; 2017 Jan; 8(1):. PubMed ID: 28096492
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
    Cynis H; Schilling S; Bodnár M; Hoffmann T; Heiser U; Saido TC; Demuth HU
    Biochim Biophys Acta; 2006 Oct; 1764(10):1618-25. PubMed ID: 17005457
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.
    Morawski M; Schilling S; Kreuzberger M; Waniek A; Jäger C; Koch B; Cynis H; Kehlen A; Arendt T; Hartlage-Rübsamen M; Demuth HU; Roßner S
    J Alzheimers Dis; 2014; 39(2):385-400. PubMed ID: 24164736
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
    Schilling S; Appl T; Hoffmann T; Cynis H; Schulz K; Jagla W; Friedrich D; Wermann M; Buchholz M; Heiser U; von Hörsten S; Demuth HU
    J Neurochem; 2008 Aug; 106(3):1225-36. PubMed ID: 18627432
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo.
    Shih YP; Chou CC; Chen YL; Huang KF; Wang AH
    PLoS One; 2014; 9(4):e94812. PubMed ID: 24733552
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
    Schilling S; Hoffmann T; Manhart S; Hoffmann M; Demuth HU
    FEBS Lett; 2004 Apr; 563(1-3):191-6. PubMed ID: 15063747
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases.
    Zhang Y; Wang Y; Zhao Z; Peng W; Wang P; Xu X; Zhao C
    Eur J Pharmacol; 2022 Sep; 931():175178. PubMed ID: 35948163
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Method to convert N-terminal glutamine to pyroglutamate for characterization of recombinant monoclonal antibodies.
    Xu W; Peng Y; Wang F; Paporello B; Richardson D; Liu H
    Anal Biochem; 2013 May; 436(1):10-2. PubMed ID: 23357233
    [TBL] [Abstract][Full Text] [Related]  

  • 14. IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
    Becker A; Eichentopf R; Sedlmeier R; Waniek A; Cynis H; Koch B; Stephan A; Bäuscher C; Kohlmann S; Hoffmann T; Kehlen A; Berg S; Freyse EJ; Osmand A; Plank AC; Roßner S; von Hörsten S; Graubner S; Demuth HU; Schilling S
    Biol Chem; 2016 Jan; 397(1):45-55. PubMed ID: 26351917
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro.
    Antonyan A; Schlenzig D; Schilling S; Naumann M; Sharoyan S; Mardanyan S; Demuth HU
    Neurochem Int; 2018 Feb; 113():112-119. PubMed ID: 29224965
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.
    Schilling S; Stenzel I; von Bohlen A; Wermann M; Schulz K; Demuth HU; Wasternack C
    Biol Chem; 2007 Feb; 388(2):145-53. PubMed ID: 17261077
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recombinant production of isotope-labeled peptides and spontaneous cyclization of amino-terminal glutamine into pyroglutamic acid.
    Mischo A; Ohlenschläger O; Gührs KH; Görlach M
    Chembiochem; 2012 Jul; 13(10):1421-3. PubMed ID: 22619187
    [No Abstract]   [Full Text] [Related]  

  • 18. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
    Schilling S; Kohlmann S; Bäuscher C; Sedlmeier R; Koch B; Eichentopf R; Becker A; Cynis H; Hoffmann T; Berg S; Freyse EJ; von Hörsten S; Rossner S; Graubner S; Demuth HU
    J Biol Chem; 2011 Apr; 286(16):14199-208. PubMed ID: 21330373
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Oxidative folding and N-terminal cyclization of onconase.
    Welker E; Hathaway L; Xu G; Narayan M; Pradeep L; Shin HC; Scheraga HA
    Biochemistry; 2007 May; 46(18):5485-93. PubMed ID: 17439243
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.
    Koch B; Kolenko P; Buchholz M; Carrillo DR; Parthier C; Wermann M; Rahfeld JU; Reuter G; Schilling S; Stubbs MT; Demuth HU
    Biochemistry; 2012 Sep; 51(37):7383-92. PubMed ID: 22897232
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.