These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

104 related articles for article (PubMed ID: 25988615)

  • 21. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
    Auchus RJ; Miller WL
    Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
    [TBL] [Abstract][Full Text] [Related]  

  • 22. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells.
    Faletrov YV; Efimova VS; Horetski MS; Tugaeva KV; Frolova NS; Lin Q; Isaeva LV; Rubtsov MA; Sluchanko NN; Novikova LA; Shkumatov VM
    Chem Phys Lipids; 2020 Mar; 227():104850. PubMed ID: 31836520
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Pregnenolone derivatives as potential anticancer agents.
    Iqbal Choudhary M; Shahab Alam M; Atta-Ur-Rahman ; Yousuf S; Wu YC; Lin AS; Shaheen F
    Steroids; 2011 Dec; 76(14):1554-9. PubMed ID: 21964577
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.
    Pinto-Bazurco Mendieta MA; Negri M; Jagusch C; Hille UE; Müller-Vieira U; Schmidt D; Hansen K; Hartmann RW
    Bioorg Med Chem Lett; 2008 Jan; 18(1):267-73. PubMed ID: 18024111
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Novel mutation of the CYP17 gene in two unrelated patients with combined 17alpha-hydroxylase/17,20-lyase deficiency: demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling.
    Patocs A; Liko I; Varga I; Gergics P; Boros A; Futo L; Kun I; Bertalan R; Toth S; Pazmany T; Toth M; Szücs N; Horanyi J; Glaz E; Racz K
    J Steroid Biochem Mol Biol; 2005 Nov; 97(3):257-65. PubMed ID: 16176874
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
    Stefanachi A; Favia AD; Nicolotti O; Leonetti F; Pisani L; Catto M; Zimmer C; Hartmann RW; Carotti A
    J Med Chem; 2011 Mar; 54(6):1613-25. PubMed ID: 21341743
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors.
    Wang M; Fang Y; Gu S; Chen F; Zhu Z; Sun X; Zhu J
    Eur J Med Chem; 2017 May; 132():157-172. PubMed ID: 28350999
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
    Rafferty SW; Eisner JR; Moore WR; Schotzinger RJ; Hoekstra WJ
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2444-7. PubMed ID: 24775307
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.
    Hu Q; Jagusch C; Hille UE; Haupenthal J; Hartmann RW
    J Med Chem; 2010 Aug; 53(15):5749-58. PubMed ID: 20684610
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The role of fluorine substitution in biphenyl methylene imidazole-type CYP17 inhibitors for the treatment of prostate carcinoma.
    Hu Q; Negri M; Olgen S; Hartmann RW
    ChemMedChem; 2010 Jun; 5(6):899-910. PubMed ID: 20437447
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.
    Jarman M; Barrie SE; Llera JM
    J Med Chem; 1998 Dec; 41(27):5375-81. PubMed ID: 9876107
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Oxazolinyl derivatives of [17(20)E]-21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity.
    Kostin VA; Zolottsev VA; Kuzikov AV; Masamrekh RA; Shumyantseva VV; Veselovsky AV; Stulov SV; Novikov RA; Timofeev VP; Misharin AY
    Steroids; 2016 Nov; 115():114-122. PubMed ID: 27505042
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors.
    Pingaew R; Prachayasittikul V; Mandi P; Nantasenamat C; Prachayasittikul S; Ruchirawat S; Prachayasittikul V
    Bioorg Med Chem; 2015 Jul; 23(13):3472-80. PubMed ID: 25934226
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase.
    Burkhart JP; Weintraub PM; Gates CA; Resvick RJ; Vaz RJ; Friedrich D; Angelastro MR; Bey P; Peet NP
    Bioorg Med Chem; 2002 Apr; 10(4):929-34. PubMed ID: 11836100
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.
    Ferlin MG; Carta D; Bortolozzi R; Ghodsi R; Chimento A; Pezzi V; Moro S; Hanke N; Hartmann RW; Basso G; Viola G
    J Med Chem; 2013 Oct; 56(19):7536-51. PubMed ID: 24025069
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis of 3beta, 7alpha, 11alpha-trihydroxy-pregn-21-benzylidene-5-en-20-one derivatives and their cytotoxic activities.
    Shan LH; Liu HM; Huang KX; Dai GF; Cao C; Dong RJ
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6637-9. PubMed ID: 19864129
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
    Moreira VM; Vasaitis TS; Njar VC; Salvador JA
    Steroids; 2007 Dec; 72(14):939-48. PubMed ID: 17884122
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.
    Haider SM; Patel JS; Poojari CS; Neidle S
    J Mol Biol; 2010 Jul; 400(5):1078-98. PubMed ID: 20595043
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.
    Van Den Akker EL; Koper JW; Boehmer AL; Themmen AP; Verhoef-Post M; Timmerman MA; Otten BJ; Drop SL; De Jong FH
    J Clin Endocrinol Metab; 2002 Dec; 87(12):5714-21. PubMed ID: 12466376
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
    Li JS; Li Y; Son C; Brodie AM
    J Med Chem; 1996 Oct; 39(21):4335-9. PubMed ID: 8863811
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.