These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4. Fan C; Wang X Cell Cycle; 2017 Apr; 16(7):660-664. PubMed ID: 28166445 [TBL] [Abstract][Full Text] [Related]
3. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Wade M; Li YC; Matani AS; Braun SM; Milanesi F; Rodewald LW; Wahl GM Oncogene; 2012 Nov; 31(45):4789-97. PubMed ID: 22266850 [TBL] [Abstract][Full Text] [Related]
5. Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy. Pellegrino M; Mancini F; Lucà R; Coletti A; Giacchè N; Manni I; Arisi I; Florenzano F; Teveroni E; Buttarelli M; Fici L; Brandi R; Bruno T; Fanciulli M; D'Onofrio M; Piaggio G; Pellicciari R; Pontecorvi A; Marine JC; Macchiarulo A; Moretti F Cancer Res; 2015 Nov; 75(21):4560-72. PubMed ID: 26359458 [TBL] [Abstract][Full Text] [Related]
6. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Parant J; Chavez-Reyes A; Little NA; Yan W; Reinke V; Jochemsen AG; Lozano G Nat Genet; 2001 Sep; 29(1):92-5. PubMed ID: 11528400 [TBL] [Abstract][Full Text] [Related]
7. Dual Targeting of MDM4 and FTH1 by MMRi71 for Induced Protein Degradation and p53-Independent Apoptosis in Leukemia Cells. Lama R; Galster SL; Xu C; Davison LW; Chemler SR; Wang X Molecules; 2022 Nov; 27(22):. PubMed ID: 36431769 [TBL] [Abstract][Full Text] [Related]
8. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Li Z; Day CP; Yang JY; Tsai WB; Lozano G; Shih HM; Hung MC Cancer Res; 2004 Dec; 64(24):9080-5. PubMed ID: 15604276 [TBL] [Abstract][Full Text] [Related]
9. Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation. Ghosh M; Huang K; Berberich SJ Biochemistry; 2003 Mar; 42(8):2291-9. PubMed ID: 12600196 [TBL] [Abstract][Full Text] [Related]
10. Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2. Vogel SM; Bauer MR; Joerger AC; Wilcken R; Brandt T; Veprintsev DB; Rutherford TJ; Fersht AR; Boeckler FM Proc Natl Acad Sci U S A; 2012 Oct; 109(42):16906-10. PubMed ID: 23035244 [TBL] [Abstract][Full Text] [Related]
11. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Pant V; Xiong S; Iwakuma T; Quintás-Cardama A; Lozano G Proc Natl Acad Sci U S A; 2011 Jul; 108(29):11995-2000. PubMed ID: 21730132 [TBL] [Abstract][Full Text] [Related]
12. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. Singh RK; Iyappan S; Scheffner M J Biol Chem; 2007 Apr; 282(15):10901-7. PubMed ID: 17301054 [TBL] [Abstract][Full Text] [Related]
13. Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. Ranaweera RS; Yang X J Biol Chem; 2013 Jun; 288(26):18939-46. PubMed ID: 23671280 [TBL] [Abstract][Full Text] [Related]
14. Regulation of p53 and MDM2 activity by MTBP. Brady M; Vlatkovic N; Boyd MT Mol Cell Biol; 2005 Jan; 25(2):545-53. PubMed ID: 15632057 [TBL] [Abstract][Full Text] [Related]
15. Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. Nie J; Xie P; Liu L; Xing G; Chang Z; Yin Y; Tian C; He F; Zhang L J Biol Chem; 2010 Jul; 285(30):22818-30. PubMed ID: 20484049 [TBL] [Abstract][Full Text] [Related]
16. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Toledo F; Wahl GM Int J Biochem Cell Biol; 2007; 39(7-8):1476-82. PubMed ID: 17499002 [TBL] [Abstract][Full Text] [Related]
17. A site-directed mutagenesis study of the MdmX RING domain. Egorova O; Mis M; Sheng Y Biochem Biophys Res Commun; 2014 May; 447(4):696-701. PubMed ID: 24755078 [TBL] [Abstract][Full Text] [Related]
18. Inhibition of p53 degradation by Mdm2 acetylation. Wang X; Taplick J; Geva N; Oren M FEBS Lett; 2004 Mar; 561(1-3):195-201. PubMed ID: 15013777 [TBL] [Abstract][Full Text] [Related]
19. High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Valentin-Vega YA; Barboza JA; Chau GP; El-Naggar AK; Lozano G Hum Pathol; 2007 Oct; 38(10):1553-62. PubMed ID: 17651783 [TBL] [Abstract][Full Text] [Related]
20. Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity. Yang L; Song T; Cheng Q; Chen L; Chen J Mol Cell Biol; 2019 Feb; 39(4):. PubMed ID: 30455251 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]