311 related articles for article (PubMed ID: 26005835)
21. Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer.
Theard PL; Sheffels E; Sealover NE; Linke AJ; Pratico DJ; Kortum RL
Elife; 2020 Sep; 9():. PubMed ID: 32897190
[TBL] [Abstract][Full Text] [Related]
22. One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
Ramharter J; Kessler D; Ettmayer P; Hofmann MH; Gerstberger T; Gmachl M; Wunberg T; Kofink C; Sanderson M; Arnhof H; Bader G; Rumpel K; Zöphel A; Schnitzer R; Böttcher J; O'Connell JC; Mendes RL; Richard D; Pototschnig N; Weiner I; Hela W; Hauer K; Haering D; Lamarre L; Wolkerstorfer B; Salamon C; Werni P; Munico-Martinez S; Meyer R; Kennedy MD; Kraut N; McConnell DB
J Med Chem; 2021 May; 64(10):6569-6580. PubMed ID: 33719426
[TBL] [Abstract][Full Text] [Related]
23. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
Roose JP; Mollenauer M; Gupta VA; Stone J; Weiss A
Mol Cell Biol; 2005 Jun; 25(11):4426-41. PubMed ID: 15899849
[TBL] [Abstract][Full Text] [Related]
24. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells.
Diersch S; Wirth M; Schneeweis C; Jörs S; Geisler F; Siveke JT; Rad R; Schmid RM; Saur D; Rustgi AK; Reichert M; Schneider G
Oncogene; 2016 Jul; 35(29):3880-6. PubMed ID: 26592448
[TBL] [Abstract][Full Text] [Related]
25. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C; Ksionda O; Lemmens E; Coakley K; Yang M; Dail M; Harvey RC; Govern C; Bakker J; Lenstra TL; Ammon K; Boeter A; Winter SS; Loh M; Shannon K; Chakraborty AK; Wabl M; Roose JP
Sci Signal; 2013 Mar; 6(268):ra21. PubMed ID: 23532335
[TBL] [Abstract][Full Text] [Related]
26. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth.
Li D; Zhang Y; Liu K; Zhao Y; Xu B; Xu L; Tan L; Tian Y; Li C; Zhang W; Cao H; Zhan YY; Hu T
Lab Invest; 2017 Nov; 97(11):1343-1353. PubMed ID: 28759012
[TBL] [Abstract][Full Text] [Related]
27. Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.
Lee SK; Hwang JH; Choi KY
Adv Biol Regul; 2018 May; 68():46-54. PubMed ID: 29449169
[TBL] [Abstract][Full Text] [Related]
28. EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells.
De S; Dermawan JK; Stark GR
Proc Natl Acad Sci U S A; 2014 Aug; 111(32):11721-6. PubMed ID: 25071181
[TBL] [Abstract][Full Text] [Related]
29. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Xiao Z; Li L; Li Y; Zhou W; Cheng J; Liu F; Zheng P; Zhang Y; Che Y
Cell Death Dis; 2014 May; 5(5):e1241. PubMed ID: 24853419
[TBL] [Abstract][Full Text] [Related]
30. Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells.
Unson S; Chang TC; Yang YN; Wang SH; Huang CH; Crawford DR; Huang HM; Li ZL; Lin HY; Whang-Peng J; Wang K; Davis PJ; Li WS
Mar Drugs; 2022 Jul; 20(8):. PubMed ID: 36005485
[TBL] [Abstract][Full Text] [Related]
31. CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Ichise T; Yoshida N; Ichise H
J Pathol; 2019 Sep; 249(1):39-51. PubMed ID: 30953353
[TBL] [Abstract][Full Text] [Related]
32. Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
Wang DZ; Hammond VE; Abud HE; Bertoncello I; McAvoy JW; Bowtell DD
Genes Dev; 1997 Feb; 11(3):309-20. PubMed ID: 9030684
[TBL] [Abstract][Full Text] [Related]
33. TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.
Oberst MD; Beberman SJ; Zhao L; Yin JJ; Ward Y; Kelly K
BMC Cancer; 2008 Jul; 8():189. PubMed ID: 18597688
[TBL] [Abstract][Full Text] [Related]
34. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.
Cheung HW; Du J; Boehm JS; He F; Weir BA; Wang X; Butaney M; Sequist LV; Luo B; Engelman JA; Root DE; Meyerson M; Golub TR; Jänne PA; Hahn WC
Cancer Discov; 2011 Dec; 1(7):608-25. PubMed ID: 22586683
[TBL] [Abstract][Full Text] [Related]
35. Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.
Moon BS; Jeong WJ; Park J; Kim TI; Min do S; Choi KY
J Natl Cancer Inst; 2014 Feb; 106(2):djt373. PubMed ID: 24491301
[TBL] [Abstract][Full Text] [Related]
36. Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines.
Vitiello PP; Cardone C; Martini G; Ciardiello D; Belli V; Matrone N; Barra G; Napolitano S; Della Corte C; Turano M; Furia M; Troiani T; Morgillo F; De Vita F; Ciardiello F; Martinelli E
J Exp Clin Cancer Res; 2019 Jan; 38(1):41. PubMed ID: 30691487
[TBL] [Abstract][Full Text] [Related]
37. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Luo F; Brooks DG; Ye H; Hamoudi R; Poulogiannis G; Patek CE; Winton DJ; Arends MJ
Int J Exp Pathol; 2009 Oct; 90(5):558-74. PubMed ID: 19765110
[TBL] [Abstract][Full Text] [Related]
38. Design of Orally-bioavailable Tetra-cyclic phthalazine SOS1 inhibitors with high selectivity against EGFR.
He H; Chen R; Wang Z; Qing L; Zhang Y; Liu Y; Pan W; Fang H; Zhang S
Bioorg Chem; 2023 Jul; 136():106536. PubMed ID: 37054529
[TBL] [Abstract][Full Text] [Related]
39. Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.
Dietinger V; García de Durango CR; Wiechmann S; Boos SL; Michl M; Neumann J; Hermeking H; Kuster B; Jung P
Cell Commun Signal; 2020 Jun; 18(1):102. PubMed ID: 32586342
[TBL] [Abstract][Full Text] [Related]
40. The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.
de la Luz Sierra M; Sakakibara S; Gasperini P; Salvucci O; Jiang K; McCormick PJ; Segarra M; Stone J; Maric D; Zhu J; Qian X; Lowy DR; Tosato G
Blood; 2010 May; 115(19):3970-9. PubMed ID: 20203268
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]