BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

686 related articles for article (PubMed ID: 26012548)

  • 1. Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.
    Yin S; Cao W
    Mol Cell Biol; 2015 Aug; 35(15):2673-83. PubMed ID: 26012548
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
    Komatsu M; Kurokawa H; Waguri S; Taguchi K; Kobayashi A; Ichimura Y; Sou YS; Ueno I; Sakamoto A; Tong KI; Kim M; Nishito Y; Iemura S; Natsume T; Ueno T; Kominami E; Motohashi H; Tanaka K; Yamamoto M
    Nat Cell Biol; 2010 Mar; 12(3):213-23. PubMed ID: 20173742
    [TBL] [Abstract][Full Text] [Related]  

  • 3. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
    Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
    J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
    Park JS; Kang DH; Lee DH; Bae SH
    Biochem Biophys Res Commun; 2015 Oct; 466(3):499-504. PubMed ID: 26381178
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.
    Park JS; Kang DH; Lee DH; Bae SH
    Biochem Biophys Res Commun; 2015 Oct; 466(1):131-7. PubMed ID: 26325428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation.
    Fujita K; Maeda D; Xiao Q; Srinivasula SM
    Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1427-32. PubMed ID: 21220332
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
    Inami Y; Waguri S; Sakamoto A; Kouno T; Nakada K; Hino O; Watanabe S; Ando J; Iwadate M; Yamamoto M; Lee MS; Tanaka K; Komatsu M
    J Cell Biol; 2011 Apr; 193(2):275-84. PubMed ID: 21482715
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Taguchi K; Fujikawa N; Komatsu M; Ishii T; Unno M; Akaike T; Motohashi H; Yamamoto M
    Proc Natl Acad Sci U S A; 2012 Aug; 109(34):13561-6. PubMed ID: 22872865
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
    Park JS; Kang DH; Lee DH; Bae SH
    Biochem Biophys Res Commun; 2015 Sep; 465(3):542-7. PubMed ID: 26282199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner.
    Lau A; Zheng Y; Tao S; Wang H; Whitman SA; White E; Zhang DD
    Mol Cell Biol; 2013 Jun; 33(12):2436-46. PubMed ID: 23589329
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
    Lau A; Wang XJ; Zhao F; Villeneuve NF; Wu T; Jiang T; Sun Z; White E; Zhang DD
    Mol Cell Biol; 2010 Jul; 30(13):3275-85. PubMed ID: 20421418
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
    Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M
    Mol Cell; 2013 Sep; 51(5):618-31. PubMed ID: 24011591
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
    Kageyama S; Sou YS; Uemura T; Kametaka S; Saito T; Ishimura R; Kouno T; Bedford L; Mayer RJ; Lee MS; Yamamoto M; Waguri S; Tanaka K; Komatsu M
    J Biol Chem; 2014 Sep; 289(36):24944-55. PubMed ID: 25049227
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
    Fan W; Tang Z; Chen D; Moughon D; Ding X; Chen S; Zhu M; Zhong Q
    Autophagy; 2010 Jul; 6(5):614-21. PubMed ID: 20495340
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 Pathway.
    Choi Y; Jiang Z; Shin WJ; Jung JU
    J Virol; 2020 Feb; 94(6):. PubMed ID: 31852783
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy.
    Zhang W; Feng C; Jiang H
    Ageing Res Rev; 2021 Jan; 65():101207. PubMed ID: 33144123
    [TBL] [Abstract][Full Text] [Related]  

  • 17. p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway.
    Liao W; Wang Z; Fu Z; Ma H; Jiang M; Xu A; Zhang W
    Free Radic Res; 2019 Jul; 53(7):800-814. PubMed ID: 31223046
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis.
    Stępkowski TM; Kruszewski MK
    Free Radic Biol Med; 2011 May; 50(9):1186-95. PubMed ID: 21295136
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 20. SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
    Darvekar SR; Elvenes J; Brenne HB; Johansen T; Sjøttem E
    PLoS One; 2014; 9(1):e85262. PubMed ID: 24416372
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 35.