280 related articles for article (PubMed ID: 26013035)
1. HDAC8: a multifaceted target for therapeutic interventions.
Chakrabarti A; Oehme I; Witt O; Oliveira G; Sippl W; Romier C; Pierce RJ; Jung M
Trends Pharmacol Sci; 2015 Jul; 36(7):481-92. PubMed ID: 26013035
[TBL] [Abstract][Full Text] [Related]
2. Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders.
Decroos C; Christianson NH; Gullett LE; Bowman CM; Christianson KE; Deardorff MA; Christianson DW
Biochemistry; 2015 Oct; 54(42):6501-13. PubMed ID: 26463496
[TBL] [Abstract][Full Text] [Related]
3. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Vannini A; Volpari C; Filocamo G; Casavola EC; Brunetti M; Renzoni D; Chakravarty P; Paolini C; De Francesco R; Gallinari P; Steinkühler C; Di Marco S
Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15064-9. PubMed ID: 15477595
[TBL] [Abstract][Full Text] [Related]
4. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Krennhrubec K; Marshall BL; Hedglin M; Verdin E; Ulrich SM
Bioorg Med Chem Lett; 2007 May; 17(10):2874-8. PubMed ID: 17346959
[TBL] [Abstract][Full Text] [Related]
5. Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.
Decroos C; Bowman CM; Moser JA; Christianson KE; Deardorff MA; Christianson DW
ACS Chem Biol; 2014 Sep; 9(9):2157-64. PubMed ID: 25075551
[TBL] [Abstract][Full Text] [Related]
6. Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.
Chakrabarti A; Melesina J; Kolbinger FR; Oehme I; Senger J; Witt O; Sippl W; Jung M
Future Med Chem; 2016 Sep; 8(13):1609-34. PubMed ID: 27572818
[TBL] [Abstract][Full Text] [Related]
7. Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.
Banerjee S; Adhikari N; Amin SA; Jha T
Eur J Med Chem; 2019 Feb; 164():214-240. PubMed ID: 30594678
[TBL] [Abstract][Full Text] [Related]
8. Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.
Deardorff MA; Porter NJ; Christianson DW
Protein Sci; 2016 Nov; 25(11):1965-1976. PubMed ID: 27576763
[TBL] [Abstract][Full Text] [Related]
9. Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.
Kaiser FJ; Ansari M; Braunholz D; Concepción Gil-Rodríguez M; Decroos C; Wilde JJ; Fincher CT; Kaur M; Bando M; Amor DJ; Atwal PS; Bahlo M; Bowman CM; Bradley JJ; Brunner HG; Clark D; Del Campo M; Di Donato N; Diakumis P; Dubbs H; Dyment DA; Eckhold J; Ernst S; Ferreira JC; Francey LJ; Gehlken U; Guillén-Navarro E; Gyftodimou Y; Hall BD; Hennekam R; Hudgins L; Hullings M; Hunter JM; Yntema H; Innes AM; Kline AD; Krumina Z; Lee H; Leppig K; Lynch SA; Mallozzi MB; Mannini L; McKee S; Mehta SG; Micule I; ; Mohammed S; Moran E; Mortier GR; Moser JA; Noon SE; Nozaki N; Nunes L; Pappas JG; Penney LS; Pérez-Aytés A; Petersen MB; Puisac B; Revencu N; Roeder E; Saitta S; Scheuerle AE; Schindeler KL; Siu VM; Stark Z; Strom SP; Thiese H; Vater I; Willems P; Williamson K; Wilson LC; ; Hakonarson H; Quintero-Rivera F; Wierzba J; Musio A; Gillessen-Kaesbach G; Ramos FJ; Jackson LG; Shirahige K; Pié J; Christianson DW; Krantz ID; Fitzpatrick DR; Deardorff MA
Hum Mol Genet; 2014 Jun; 23(11):2888-900. PubMed ID: 24403048
[TBL] [Abstract][Full Text] [Related]
10. Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme.
Singh RK; Suzuki T; Mandal T; Balsubramanian N; Haldar M; Mueller DJ; Strode JA; Cook G; Mallik S; Srivastava DK
Biochemistry; 2014 Dec; 53(48):7445-58. PubMed ID: 25407689
[TBL] [Abstract][Full Text] [Related]
11. Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
Osko JD; Porter NJ; Decroos C; Lee MS; Watson PR; Raible SE; Krantz ID; Deardorff MA; Christianson DW
J Struct Biol; 2021 Mar; 213(1):107681. PubMed ID: 33316326
[TBL] [Abstract][Full Text] [Related]
12. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
Marek M; Shaik TB; Heimburg T; Chakrabarti A; Lancelot J; Ramos-Morales E; Da Veiga C; Kalinin D; Melesina J; Robaa D; Schmidtkunz K; Suzuki T; Holl R; Ennifar E; Pierce RJ; Jung M; Sippl W; Romier C
J Med Chem; 2018 Nov; 61(22):10000-10016. PubMed ID: 30347148
[TBL] [Abstract][Full Text] [Related]
13. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
Somoza JR; Skene RJ; Katz BA; Mol C; Ho JD; Jennings AJ; Luong C; Arvai A; Buggy JJ; Chi E; Tang J; Sang BC; Verner E; Wynands R; Leahy EM; Dougan DR; Snell G; Navre M; Knuth MW; Swanson RV; McRee DE; Tari LW
Structure; 2004 Jul; 12(7):1325-34. PubMed ID: 15242608
[TBL] [Abstract][Full Text] [Related]
14. Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.
Hassan MM; Sedighi A; Olaoye OO; Häberli C; Merz A; Ramos-Morales E; de Araujo ED; Romier C; Jung M; Keiser J; Gunning PT
ChemMedChem; 2022 Sep; 17(18):e202100622. PubMed ID: 35983937
[TBL] [Abstract][Full Text] [Related]
15. Pathological Role of HDAC8: Cancer and Beyond.
Kim JY; Cho H; Yoo J; Kim GW; Jeon YH; Lee SW; Kwon SH
Cells; 2022 Oct; 11(19):. PubMed ID: 36231123
[TBL] [Abstract][Full Text] [Related]
16. HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry.
Rajaraman S; Balakrishnan R; Deshmukh D; Ganorkar A; Biswas S; Pulya S; Ghosh B
Future Med Chem; 2023 May; 15(10):885-908. PubMed ID: 37227732
[TBL] [Abstract][Full Text] [Related]
17. Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Stolfa DA; Marek M; Lancelot J; Hauser AT; Walter A; Leproult E; Melesina J; Rumpf T; Wurtz JM; Cavarelli J; Sippl W; Pierce RJ; Romier C; Jung M
J Mol Biol; 2014 Oct; 426(20):3442-53. PubMed ID: 24657767
[TBL] [Abstract][Full Text] [Related]
18. Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.
Muth M; Jänsch N; Kopranovic A; Krämer A; Wössner N; Jung M; Kirschhöfer F; Brenner-Weiß G; Meyer-Almes FJ
Biochim Biophys Acta Gen Subj; 2019 Mar; 1863(3):577-585. PubMed ID: 30611847
[TBL] [Abstract][Full Text] [Related]
19. A novel de novo HDAC8 missense mutation causing Cornelia de Lange syndrome.
Mio C; Passon N; Fogolari F; Cesario C; Novelli A; Pittini C; Damante G
Mol Genet Genomic Med; 2021 Sep; 9(9):e1612. PubMed ID: 34342180
[TBL] [Abstract][Full Text] [Related]
20. Selective and nonselective HDAC8 inhibitors: a therapeutic patent review.
Adhikari N; Amin SA; Jha T
Pharm Pat Anal; 2018 Nov; 7(6):259-276. PubMed ID: 30632447
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
