These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Preclinical rationale for PI3K/Akt/mTOR pathway inhibitors as therapy for epidermal growth factor receptor inhibitor-resistant non-small-cell lung cancer. Gadgeel SM; Wozniak A Clin Lung Cancer; 2013 Jul; 14(4):322-32. PubMed ID: 23332287 [TBL] [Abstract][Full Text] [Related]
5. Polyphyllin II Restores Sensitization of the Resistance of PC-9/ZD Cells to Gefitinib by a Negative Regulation of the PI3K/Akt/mTOR Signaling Pathway. Zheng R; Jiang H; Li J; Liu X; Xu H Curr Cancer Drug Targets; 2017; 17(4):376-385. PubMed ID: 28093061 [TBL] [Abstract][Full Text] [Related]
7. MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer. Li B; Ren S; Li X; Wang Y; Garfield D; Zhou S; Chen X; Su C; Chen M; Kuang P; Gao G; He Y; Fan L; Fei K; Zhou C; Schmit-Bindert G Lung Cancer; 2014 Feb; 83(2):146-53. PubMed ID: 24331411 [TBL] [Abstract][Full Text] [Related]
8. PARP1 promotes EGFR-TKI drug-resistance via PI3K/AKT pathway in non-small-cell lung cancer. Xu X; Liu Y; Gong Q; Ma L; Wei W; Zhao L; Luo Z Cancer Chemother Pharmacol; 2024 Aug; 94(2):209-221. PubMed ID: 38609654 [TBL] [Abstract][Full Text] [Related]
9. Combined treatment with erlotinib and a transforming growth factor-β type I receptor inhibitor effectively suppresses the enhanced motility of erlotinib-resistant non-small-cell lung cancer cells. Serizawa M; Takahashi T; Yamamoto N; Koh Y J Thorac Oncol; 2013 Mar; 8(3):259-69. PubMed ID: 23334091 [TBL] [Abstract][Full Text] [Related]
10. Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors. Dong S; Zhang XC; Cheng H; Zhu JQ; Chen ZH; Zhang YF; Xie Z; Wu YL Cancer Chemother Pharmacol; 2012 Nov; 70(5):707-16. PubMed ID: 22941374 [TBL] [Abstract][Full Text] [Related]
11. The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-Met inhibition. Nakachi I; Naoki K; Soejima K; Kawada I; Watanabe H; Yasuda H; Nakayama S; Yoda S; Satomi R; Ikemura S; Terai H; Sato T; Ishizaka A Mol Cancer Res; 2010 Aug; 8(8):1142-51. PubMed ID: 20647329 [TBL] [Abstract][Full Text] [Related]
12. MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells. Presutti D; Santini S; Cardinali B; Papoff G; Lalli C; Samperna S; Fustaino V; Giannini G; Ruberti G PLoS One; 2015; 10(11):e0143333. PubMed ID: 26580964 [TBL] [Abstract][Full Text] [Related]
13. Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo. Xie M; He CS; Wei SH; Zhang L Eur J Cancer; 2013 Nov; 49(16):3559-72. PubMed ID: 23916913 [TBL] [Abstract][Full Text] [Related]
14. Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Wang L; Dong X; Ren Y; Luo J; Liu P; Su D; Yang X Cell Death Dis; 2018 Jan; 9(2):129. PubMed ID: 29374157 [TBL] [Abstract][Full Text] [Related]
15. Increased expression of miR-641 contributes to erlotinib resistance in non-small-cell lung cancer cells by targeting NF1. Chen J; Cui JD; Guo XT; Cao X; Li Q Cancer Med; 2018 Apr; 7(4):1394-1403. PubMed ID: 29493886 [TBL] [Abstract][Full Text] [Related]
16. P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer. Venkatesha VA; Joshi A; Venkataraman M; Sonawane V; Bhatia D; Tannu P; Bose J; Choudhari S; Srivastava A; Pandey PK; Lad VJ; Sangana R; Ahmed T; Damre A; Deore V; Sahu B; Kumar S; Sharma S; Agarwal VR Mol Cancer; 2014 Dec; 13():259. PubMed ID: 25466244 [TBL] [Abstract][Full Text] [Related]
17. Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. Donev IS; Wang W; Yamada T; Li Q; Takeuchi S; Matsumoto K; Yamori T; Nishioka Y; Sone S; Yano S Clin Cancer Res; 2011 Apr; 17(8):2260-9. PubMed ID: 21220474 [TBL] [Abstract][Full Text] [Related]
18. Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells. Choi JM; Jang JY; Choi YR; Kim HR; Cho BC; Lee HW Lung Cancer; 2015 Nov; 90(2):175-81. PubMed ID: 26342551 [TBL] [Abstract][Full Text] [Related]
19. 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer. Zannetti A; Iommelli F; Speranza A; Salvatore M; Del Vecchio S J Nucl Med; 2012 Mar; 53(3):443-50. PubMed ID: 22331221 [TBL] [Abstract][Full Text] [Related]
20. Clinical impact of switching to a second EGFR-TKI after a severe AE related to a first EGFR-TKI in EGFR-mutated NSCLC. Takeda M; Okamoto I; Tsurutani J; Oiso N; Kawada A; Nakagawa K Jpn J Clin Oncol; 2012 Jun; 42(6):528-33. PubMed ID: 22457323 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]