115 related articles for article (PubMed ID: 26043946)
1. PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
Kim Y; Maciag AE; Cao Z; Deschamps JR; Saavedra JE; Keefer LK; Holland RJ
Bioorg Med Chem; 2015 Aug; 23(15):4980-4988. PubMed ID: 26043946
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.
Chakrapani H; Wilde TC; Citro ML; Goodblatt MM; Keefer LK; Saavedra JE
Bioorg Med Chem; 2008 Mar; 16(5):2657-64. PubMed ID: 18060792
[TBL] [Abstract][Full Text] [Related]
3. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins.
Townsend DM; Findlay VJ; Fazilev F; Ogle M; Fraser J; Saavedra JE; Ji X; Keefer LK; Tew KD
Mol Pharmacol; 2006 Feb; 69(2):501-8. PubMed ID: 16288082
[TBL] [Abstract][Full Text] [Related]
4. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.
Findlay VJ; Townsend DM; Saavedra JE; Buzard GS; Citro ML; Keefer LK; Ji X; Tew KD
Mol Pharmacol; 2004 May; 65(5):1070-9. PubMed ID: 15102935
[TBL] [Abstract][Full Text] [Related]
5. Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO.
Hutchens S; Manevich Y; He L; Tew KD; Townsend DM
Invest New Drugs; 2011 Oct; 29(5):719-29. PubMed ID: 20232108
[TBL] [Abstract][Full Text] [Related]
6. Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.
Kogias E; Osterberg N; Baumer B; Psarras N; Koentges C; Papazoglou A; Saavedra JE; Keefer LK; Weyerbrock A
Int J Cancer; 2012 Mar; 130(5):1184-94. PubMed ID: 21455987
[TBL] [Abstract][Full Text] [Related]
7. Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.
Fu J; Liu L; Huang Z; Lai Y; Ji H; Peng S; Tian J; Zhang Y
J Med Chem; 2013 Jun; 56(11):4641-55. PubMed ID: 23617697
[TBL] [Abstract][Full Text] [Related]
8. Glutathione
Zhang L; Kim SH; Park KH; Zhi-Wei Y; Jie Z; Townsend DM; Tew KD
J Pharmacol Exp Ther; 2021 Apr; 377(1):121-132. PubMed ID: 33514607
[TBL] [Abstract][Full Text] [Related]
9. Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.
Andrei D; Maciag AE; Chakrapani H; Citro ML; Keefer LK; Saavedra JE
J Med Chem; 2008 Dec; 51(24):7944-52. PubMed ID: 19053760
[TBL] [Abstract][Full Text] [Related]
10. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.
Harshbarger W; Gondi S; Ficarro SB; Hunter J; Udayakumar D; Gurbani D; Singer WD; Liu Y; Li L; Marto JA; Westover KD
J Biol Chem; 2017 Jan; 292(1):112-120. PubMed ID: 27872191
[TBL] [Abstract][Full Text] [Related]
11. PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.
Saavedra JE; Srinivasan A; Buzard GS; Davies KM; Waterhouse DJ; Inami K; Wilde TC; Citro ML; Cuellar M; Deschamps JR; Parrish D; Shami PJ; Findlay VJ; Townsend DM; Tew KD; Singh S; Jia L; Ji X; Keefer LK
J Med Chem; 2006 Feb; 49(3):1157-64. PubMed ID: 16451080
[TBL] [Abstract][Full Text] [Related]
12. Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.
Kumar V; Hong SY; Maciag AE; Saavedra JE; Adamson DH; Prud'homme RK; Keefer LK; Chakrapani H
Mol Pharm; 2010 Feb; 7(1):291-8. PubMed ID: 20000791
[TBL] [Abstract][Full Text] [Related]
13. Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.
Maciag AE; Holland RJ; Robert Cheng YS; Rodriguez LG; Saavedra JE; Anderson LM; Keefer LK
Redox Biol; 2013; 1(1):115-24. PubMed ID: 24024144
[TBL] [Abstract][Full Text] [Related]
14. Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Townsend DM; Manevich Y; He L; Xiong Y; Bowers RR; Hutchens S; Tew KD
Cancer Res; 2009 Oct; 69(19):7626-34. PubMed ID: 19773442
[TBL] [Abstract][Full Text] [Related]
15. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.
Shami PJ; Saavedra JE; Wang LY; Bonifant CL; Diwan BA; Singh SV; Gu Y; Fox SD; Buzard GS; Citro ML; Waterhouse DJ; Davies KM; Ji X; Keefer LK
Mol Cancer Ther; 2003 Apr; 2(4):409-17. PubMed ID: 12700285
[TBL] [Abstract][Full Text] [Related]
16. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.
Lok HC; Rahmanto YS; Hawkins CL; Kalinowski DS; Morrow CS; Townsend AJ; Ponka P; Richardson DR
J Biol Chem; 2012 Jan; 287(1):607-618. PubMed ID: 22084240
[TBL] [Abstract][Full Text] [Related]
17. Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.
Maciag AE; Holland RJ; Kim Y; Kumari V; Luthers CE; Sehareen WS; Biswas D; Morris NL; Ji X; Anderson LM; Saavedra JE; Keefer LK
J Med Chem; 2014 Mar; 57(6):2292-302. PubMed ID: 24521039
[TBL] [Abstract][Full Text] [Related]
18. [Structure and functions of glutathione S-transferase P1-1].
Slonchak AM; Obolens'ka MIu
Ukr Biokhim Zh (1999); 2009; 81(1):5-13. PubMed ID: 19877411
[TBL] [Abstract][Full Text] [Related]
19. NO donor inhibits proliferation and induces apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells.
Liu L; Chen J; Cao M; Wang J; Wang S
Cancer Chemother Pharmacol; 2019 Dec; 84(6):1303-1314. PubMed ID: 31555866
[TBL] [Abstract][Full Text] [Related]
20. Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin.
Peklak-Scott C; Smitherman PK; Townsend AJ; Morrow CS
Mol Cancer Ther; 2008 Oct; 7(10):3247-55. PubMed ID: 18852128
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
