BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 26048806)

  • 21. Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation.
    Sun N; Yuan C; Ma X; Wang Y; Gu X; Fu W
    Molecules; 2018 Dec; 23(12):. PubMed ID: 30513894
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
    Gege C; Albers M; Kinzel O; Kleymann G; Schlüter T; Steeneck C; Hoffmann T; Xue X; Cummings MD; Spurlino J; Milligan C; Fourie AM; Edwards JP; Leonard K; Coe K; Scott B; Pippel D; Goldberg SD
    Bioorg Med Chem Lett; 2020 Jun; 30(12):127205. PubMed ID: 32336498
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
    Li X; Anderson M; Collin D; Muegge I; Wan J; Brennan D; Kugler S; Terenzio D; Kennedy C; Lin S; Labadia ME; Cook B; Hughes R; Farrow NA
    J Biol Chem; 2017 Jul; 292(28):11618-11630. PubMed ID: 28546429
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
    Gege C; Schlüter T; Hoffmann T
    Bioorg Med Chem Lett; 2014 Nov; 24(22):5265-7. PubMed ID: 25305688
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Recent progress on nuclear receptor RORγ modulators.
    Cyr P; Bronner SM; Crawford JJ
    Bioorg Med Chem Lett; 2016 Sep; 26(18):4387-4393. PubMed ID: 27542308
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
    Chen L; Su M; Jin Q; Wang CG; Assani I; Wang MX; Zhao SF; Lv SM; Wang JW; Sun B; Li Y; Liao ZX
    Bioorg Chem; 2022 Feb; 119():105483. PubMed ID: 34906860
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
    Yukawa T; Nara Y; Kono M; Sato A; Oda T; Takagi T; Sato T; Banno Y; Taya N; Imada T; Shiokawa Z; Negoro N; Kawamoto T; Koyama R; Uchiyama N; Skene R; Hoffman I; Chen CH; Sang B; Snell G; Katsuyama R; Yamamoto S; Shirai J
    J Med Chem; 2019 Feb; 62(3):1167-1179. PubMed ID: 30652849
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.
    Kummer DA; Cummings MD; Abad M; Barbay J; Castro G; Wolin R; Kreutter KD; Maharoof U; Milligan C; Nishimura R; Pierce J; Schalk-Hihi C; Spurlino J; Urbanski M; Venkatesan H; Wang A; Woods C; Xue X; Edwards JP; Fourie AM; Leonard K
    Bioorg Med Chem Lett; 2017 May; 27(9):2047-2057. PubMed ID: 28318945
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
    Fauber BP; Gobbi A; Savy P; Burton B; Deng Y; Everett C; La H; Johnson AR; Lockey P; Norman M; Wong H
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4109-13. PubMed ID: 26321361
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of N-indanyl benzamides as potent RORγt inverse agonists.
    Tian J; Sun N; Yu M; Gu X; Xie Q; Shao L; Liu J; Liu L; Wang Y
    Eur J Med Chem; 2019 Apr; 167():37-48. PubMed ID: 30743096
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis.
    Ouvry G; Atrux-Tallau N; Bihl F; Bondu A; Bouix-Peter C; Carlavan I; Christin O; Cuadrado MJ; Defoin-Platel C; Deret S; Duvert D; Feret C; Forissier M; Fournier JF; Froude D; Hacini-Rachinel F; Harris CS; Hervouet C; Huguet H; Lafitte G; Luzy AP; Musicki B; Orfila D; Ozello B; Pascau C; Pascau J; Parnet V; Peluchon G; Pierre R; Piwnica D; Raffin C; Rossio P; Spiesse D; Taquet N; Thoreau E; Vatinel R; Vial E; Hennequin LF
    ChemMedChem; 2018 Feb; 13(4):321-337. PubMed ID: 29327456
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
    Yang MG; Beaudoin-Bertrand M; Xiao Z; Marcoux D; Weigelt CA; Yip S; Wu DR; Ruzanov M; Sack JS; Wang J; Yarde M; Li S; Shuster DJ; Xie JH; Sherry T; Obermeier MT; Fura A; Stefanski K; Cornelius G; Khandelwal P; Karmakar A; Basha M; Babu V; Gupta AK; Mathur A; Salter-Cid L; Denton R; Zhao Q; Dhar TGM
    J Med Chem; 2021 Mar; 64(5):2714-2724. PubMed ID: 33591748
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist.
    Wu X; Shen H; Zhang Y; Wang C; Li Q; Zhang C; Zhuang X; Li C; Shi Y; Xing Y; Xiang Q; Xu J; Wu D; Liu J; Xu Y
    J Med Chem; 2021 Jun; 64(12):8775-8797. PubMed ID: 34121397
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
    Lu Z; Duan JJ; Xiao H; Neels J; Wu DR; Weigelt CA; Sack JS; Khan J; Ruzanov M; An Y; Yarde M; Karmakar A; Vishwakrishnan S; Baratam V; Shankarappa H; Vanteru S; Babu V; Basha M; Kumar Gupta A; Kumaravel S; Mathur A; Zhao Q; Salter-Cid LM; Carter PH; Murali Dhar TG
    Bioorg Med Chem Lett; 2019 Aug; 29(16):2265-2269. PubMed ID: 31257087
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.
    Hintermann S; Guntermann C; Mattes H; Carcache DA; Wagner J; Vulpetti A; Billich A; Dawson J; Kaupmann K; Kallen J; Stringer R; Orain D
    ChemMedChem; 2016 Dec; 11(24):2640-2648. PubMed ID: 27902884
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.
    Wang Y; Cai W; Zhang G; Yang T; Liu Q; Cheng Y; Zhou L; Ma Y; Cheng Z; Lu S; Zhao YG; Zhang W; Xiang Z; Wang S; Yang L; Wu Q; Orband-Miller LA; Xu Y; Zhang J; Gao R; Huxdorf M; Xiang JN; Zhong Z; Elliott JD; Leung S; Lin X
    Bioorg Med Chem; 2014 Jan; 22(2):692-702. PubMed ID: 24388993
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.
    Meijer FA; Doveston RG; de Vries RMJM; Vos GM; Vos AAA; Leysen S; Scheepstra M; Ottmann C; Milroy LG; Brunsveld L
    J Med Chem; 2020 Jan; 63(1):241-259. PubMed ID: 31821760
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification of novel quinazolinedione derivatives as RORγt inverse agonist.
    Fukase Y; Sato A; Tomata Y; Ochida A; Kono M; Yonemori K; Koga K; Okui T; Yamasaki M; Fujitani Y; Nakagawa H; Koyama R; Nakayama M; Skene R; Sang BC; Hoffman I; Shirai J; Yamamoto S
    Bioorg Med Chem; 2018 Feb; 26(3):721-736. PubMed ID: 29342416
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists.
    Amaudrut J; Argiriadi MA; Barth M; Breinlinger EC; Bressac D; Broqua P; Calderwood DJ; Chatar M; Cusack KP; Gauld SB; Jacquet S; Kamath RV; Kort ME; Lepais V; Luccarini JM; Masson P; Montalbetti C; Mounier L; Potin D; Poupardin O; Rouaud S; Spitzer L; Wallace CD
    Bioorg Med Chem Lett; 2019 Jul; 29(14):1799-1806. PubMed ID: 31101472
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions.
    Shaikh NS; Iyer JP; Munot YS; Mukhopadhyay PP; Raje AA; Nagaraj R; Jamdar V; Gavhane R; Lohote M; Sherkar P; Bala M; Petla R; Meru A; Umrani D; Rouduri S; Joshi S; Reddy S; Kandikere V; Bhuniya D; Kulkarni B; Mookhtiar KA
    Bioorg Med Chem Lett; 2019 Aug; 29(16):2208-2217. PubMed ID: 31272795
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.