BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 26051713)

  • 1. Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
    Xu X; Choi SH; Hu T; Tiyanont K; Habets R; Groot AJ; Vooijs M; Aster JC; Chopra R; Fryer C; Blacklow SC
    Structure; 2015 Jul; 23(7):1227-35. PubMed ID: 26051713
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.
    Tiyanont K; Wales TE; Siebel CW; Engen JR; Blacklow SC
    J Mol Biol; 2013 Sep; 425(17):3192-204. PubMed ID: 23747483
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
    Gordon WR; Roy M; Vardar-Ulu D; Garfinkel M; Mansour MR; Aster JC; Blacklow SC
    Blood; 2009 Apr; 113(18):4381-90. PubMed ID: 19075186
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
    Gordon WR; Vardar-Ulu D; L'Heureux S; Ashworth T; Malecki MJ; Sanchez-Irizarry C; McArthur DG; Histen G; Mitchell JL; Aster JC; Blacklow SC
    PLoS One; 2009 Aug; 4(8):e6613. PubMed ID: 19701457
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing.
    Chen J; Zolkiewska A
    PLoS One; 2011; 6(7):e22837. PubMed ID: 21829530
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability.
    Stephenson NL; Avis JM
    FEBS Open Bio; 2015; 5():625-33. PubMed ID: 26288744
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region.
    Stephenson NL; Avis JM
    Proc Natl Acad Sci U S A; 2012 Oct; 109(41):E2757-65. PubMed ID: 23011796
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain.
    Fouillade C; Chabriat H; Riant F; Mine M; Arnoud M; Magy L; Bousser MG; Tournier-Lasserve E; Joutel A
    Hum Mutat; 2008 Mar; 29(3):452. PubMed ID: 18273901
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic antibody targeting of individual Notch receptors.
    Wu Y; Cain-Hom C; Choy L; Hagenbeek TJ; de Leon GP; Chen Y; Finkle D; Venook R; Wu X; Ridgway J; Schahin-Reed D; Dow GJ; Shelton A; Stawicki S; Watts RJ; Zhang J; Choy R; Howard P; Kadyk L; Yan M; Zha J; Callahan CA; Hymowitz SG; Siebel CW
    Nature; 2010 Apr; 464(7291):1052-7. PubMed ID: 20393564
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.
    Groot AJ; Habets R; Yahyanejad S; Hodin CM; Reiss K; Saftig P; Theys J; Vooijs M
    Mol Cell Biol; 2014 Aug; 34(15):2822-32. PubMed ID: 24842903
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis for autoinhibition of Notch.
    Gordon WR; Vardar-Ulu D; Histen G; Sanchez-Irizarry C; Aster JC; Blacklow SC
    Nat Struct Mol Biol; 2007 Apr; 14(4):295-300. PubMed ID: 17401372
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
    Bernasconi-Elias P; Hu T; Jenkins D; Firestone B; Gans S; Kurth E; Capodieci P; Deplazes-Lauber J; Petropoulos K; Thiel P; Ponsel D; Hee Choi S; LeMotte P; London A; Goetcshkes M; Nolin E; Jones MD; Slocum K; Kluk MJ; Weinstock DM; Christodoulou A; Weinberg O; Jaehrling J; Ettenberg SA; Buckler A; Blacklow SC; Aster JC; Fryer CJ
    Oncogene; 2016 Nov; 35(47):6077-6086. PubMed ID: 27157619
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3.
    Meng H; Zhang X; Yu G; Lee SJ; Chen YE; Prudovsky I; Wang MM
    PLoS One; 2012; 7(9):e44964. PubMed ID: 23028706
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Notch family members follow stringent requirements for intracellular domain dimerization at sequence-paired sites.
    Crow JJ; Albig AR
    PLoS One; 2020; 15(11):e0234101. PubMed ID: 33232323
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Notch3: from subtle structural differences to functional diversity.
    Bellavia D; Checquolo S; Campese AF; Felli MP; Gulino A; Screpanti I
    Oncogene; 2008 Sep; 27(38):5092-8. PubMed ID: 18758477
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
    Li K; Li Y; Wu W; Gordon WR; Chang DW; Lu M; Scoggin S; Fu T; Vien L; Histen G; Zheng J; Martin-Hollister R; Duensing T; Singh S; Blacklow SC; Yao Z; Aster JC; Zhou BB
    J Biol Chem; 2008 Mar; 283(12):8046-54. PubMed ID: 18182388
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Molecular Mechanism of Notch Activation.
    Lovendahl KN; Blacklow SC; Gordon WR
    Adv Exp Med Biol; 2018; 1066():47-58. PubMed ID: 30030821
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.
    Wang K; Zhang Q; Li D; Ching K; Zhang C; Zheng X; Ozeck M; Shi S; Li X; Wang H; Rejto P; Christensen J; Olson P
    Clin Cancer Res; 2015 Mar; 21(6):1487-96. PubMed ID: 25564152
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.
    Tiyanont K; Wales TE; Aste-Amezaga M; Aster JC; Engen JR; Blacklow SC
    Structure; 2011 Apr; 19(4):546-54. PubMed ID: 21481777
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept.
    Rutten JW; Dauwerse HG; Peters DJ; Goldfarb A; Venselaar H; Haffner C; van Ommen GJ; Aartsma-Rus AM; Lesnik Oberstein SA
    Brain; 2016 Apr; 139(Pt 4):1123-35. PubMed ID: 26912635
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.