BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

349 related articles for article (PubMed ID: 26051715)

  • 1. GTP-Dependent K-Ras Dimerization.
    Muratcioglu S; Chavan TS; Freed BC; Jang H; Khavrutskii L; Freed RN; Dyba MA; Stefanisko K; Tarasov SG; Gursoy A; Keskin O; Tarasova NI; Gaponenko V; Nussinov R
    Structure; 2015 Jul; 23(7):1325-35. PubMed ID: 26051715
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
    Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
    J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The higher level of complexity of K-Ras4B activation at the membrane.
    Jang H; Banerjee A; Chavan TS; Lu S; Zhang J; Gaponenko V; Nussinov R
    FASEB J; 2016 Apr; 30(4):1643-55. PubMed ID: 26718888
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
    Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
    Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
    Ito Y; Yamasaki K; Iwahara J; Terada T; Kamiya A; Shirouzu M; Muto Y; Kawai G; Yokoyama S; Laue ED; Wälchli M; Shibata T; Nishimura S; Miyazawa T
    Biochemistry; 1997 Jul; 36(30):9109-19. PubMed ID: 9230043
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.
    Jang H; Muratcioglu S; Gursoy A; Keskin O; Nussinov R
    Biochem J; 2016 Jun; 473(12):1719-32. PubMed ID: 27057007
    [TBL] [Abstract][Full Text] [Related]  

  • 7. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
    Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
    J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets.
    Moodie SA; Paris M; Villafranca E; Kirshmeier P; Willumsen BM; Wolfman A
    Oncogene; 1995 Aug; 11(3):447-54. PubMed ID: 7630628
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD.
    Fetics SK; Guterres H; Kearney BM; Buhrman G; Ma B; Nussinov R; Mattos C
    Structure; 2015 Mar; 23(3):505-516. PubMed ID: 25684575
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A structural model of a Ras-Raf signalosome.
    Mysore VP; Zhou ZW; Ambrogio C; Li L; Kapp JN; Lu C; Wang Q; Tucker MR; Okoro JJ; Nagy-Davidescu G; Bai X; Plückthun A; Jänne PA; Westover KD; Shan Y; Shaw DE
    Nat Struct Mol Biol; 2021 Oct; 28(10):847-857. PubMed ID: 34625747
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability.
    Andreadelis I; Kiriakidi S; Lamprakis C; Theodoropoulou A; Doerr S; Chatzigoulas A; Manchester J; Velez-Vega C; Duca JS; Cournia Z
    J Phys Chem B; 2022 Feb; 126(7):1504-1519. PubMed ID: 35142524
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function.
    Clark GJ; Drugan JK; Terrell RS; Bradham C; Der CJ; Bell RM; Campbell S
    Proc Natl Acad Sci U S A; 1996 Feb; 93(4):1577-81. PubMed ID: 8643674
    [TBL] [Abstract][Full Text] [Related]  

  • 13. High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
    Chavan TS; Jang H; Khavrutskii L; Abraham SJ; Banerjee A; Freed BC; Johannessen L; Tarasov SG; Gaponenko V; Nussinov R; Tarasova NI
    Biophys J; 2015 Dec; 109(12):2602-2613. PubMed ID: 26682817
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
    Johnson CW; Reid D; Parker JA; Salter S; Knihtila R; Kuzmic P; Mattos C
    J Biol Chem; 2017 Aug; 292(31):12981-12993. PubMed ID: 28630043
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Improved binding of raf to Ras.GDP is correlated with biological activity.
    Kiel C; Filchtinski D; Spoerner M; Schreiber G; Kalbitzer HR; Herrmann C
    J Biol Chem; 2009 Nov; 284(46):31893-902. PubMed ID: 19776012
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
    Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
    J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Raf-1 is involved in the regulation of the interaction between guanine nucleotide exchange factor and Ha-ras. Evidences for a function of Raf-1 and phosphatidylinositol 3-kinase upstream to Ras.
    Giglione C; Parmeggiani A
    J Biol Chem; 1998 Dec; 273(52):34737-44. PubMed ID: 9856997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.
    Nakhaeizadeh H; Amin E; Nakhaei-Rad S; Dvorsky R; Ahmadian MR
    PLoS One; 2016; 11(12):e0167145. PubMed ID: 27936046
    [TBL] [Abstract][Full Text] [Related]  

  • 19. RAS/Effector Interactions from Structural and Biophysical Perspective.
    Erijman A; Shifman JM
    Mini Rev Med Chem; 2016; 16(5):370-5. PubMed ID: 26423700
    [TBL] [Abstract][Full Text] [Related]  

  • 20. COMBINE analysis of the specificity of binding of Ras proteins to their effectors.
    Tomić S; Bertosa B; Wang T; Wade RC
    Proteins; 2007 May; 67(2):435-47. PubMed ID: 17295314
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.