BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 26056008)

  • 1. Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity.
    Ahmad S; Johnson GL; Scott JE
    Biochem Biophys Res Commun; 2015 Aug; 463(4):888-93. PubMed ID: 26056008
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.
    Ahmad S; Hughes MA; Johnson GL; Scott JE
    J Biomol Screen; 2013 Apr; 18(4):388-99. PubMed ID: 23134735
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
    Ahmad S; St Hilaire VR; Dandepally SR; Johnson GL; Williams AL; Scott JE
    Biochem Biophys Res Commun; 2018 Jan; 496(1):205-211. PubMed ID: 29309787
    [TBL] [Abstract][Full Text] [Related]  

  • 4. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
    Bok S; Shin DY; Yallowitz AR; Eiseman M; Cung M; Xu R; Li N; Sun J; Williams AL; Scott JE; Su B; Shim JH; Greenblatt MB
    Nat Commun; 2020 Nov; 11(1):5704. PubMed ID: 33177525
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ponatinib (AP24534) is a novel potent inhibitor of oncogenic RET mutants associated with thyroid cancer.
    De Falco V; Buonocore P; Muthu M; Torregrossa L; Basolo F; Billaud M; Gozgit JM; Carlomagno F; Santoro M
    J Clin Endocrinol Metab; 2013 May; 98(5):E811-9. PubMed ID: 23526464
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase.
    Mologni L; Redaelli S; Morandi A; Plaza-Menacho I; Gambacorti-Passerini C
    Mol Cell Endocrinol; 2013 Sep; 377(1-2):1-6. PubMed ID: 23811235
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.
    Lang JD; Hendricks WPD; Orlando KA; Yin H; Kiefer J; Ramos P; Sharma R; Pirrotte P; Raupach EA; Sereduk C; Tang N; Liang WS; Washington M; Facista SJ; Zismann VL; Cousins EM; Major MB; Wang Y; Karnezis AN; Sekulic A; Hass R; Vanderhyden BC; Nair P; Weissman BE; Huntsman DG; Trent JM
    Clin Cancer Res; 2018 Apr; 24(8):1932-1943. PubMed ID: 29440177
    [No Abstract]   [Full Text] [Related]  

  • 8. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.
    Najjar M; Suebsuwong C; Ray SS; Thapa RJ; Maki JL; Nogusa S; Shah S; Saleh D; Gough PJ; Bertin J; Yuan J; Balachandran S; Cuny GD; Degterev A
    Cell Rep; 2015 Mar; 10(11):1850-60. PubMed ID: 25801024
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.
    Zhang D; Facchinetti V; Wang X; Huang Q; Qin J; Su B
    EMBO J; 2006 Jan; 25(1):97-107. PubMed ID: 16362041
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Efficacy of ponatinib against ABL tyrosine kinase inhibitor-resistant leukemia cells.
    Okabe S; Tauchi T; Tanaka Y; Ohyashiki K
    Biochem Biophys Res Commun; 2013 Jun; 435(3):506-11. PubMed ID: 23684619
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1.
    Ren M; Hong M; Liu G; Wang H; Patel V; Biddinger P; Silva J; Cowell J; Hao Z
    Oncol Rep; 2013 Jun; 29(6):2181-90. PubMed ID: 23563700
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.
    Kanojia D; Garg M; Martinez J; M T A; Luty SB; Doan NB; Said JW; Forscher C; Tyner JW; Koeffler HP
    J Hematol Oncol; 2017 Nov; 10(1):173. PubMed ID: 29132397
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation.
    Zirm E; Spies-Weisshart B; Heidel F; Schnetzke U; Böhmer FD; Hochhaus A; Fischer T; Scholl S
    Br J Haematol; 2012 May; 157(4):483-92. PubMed ID: 22409268
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation.
    Enomoto A; Fukasawa T; Tsumoto H; Karube M; Nakagawa K; Yoshizaki A; Sato S; Miura Y; Miyagawa K
    Sci Rep; 2019 Nov; 9(1):16010. PubMed ID: 31690749
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance.
    Zhou T; Commodore L; Huang WS; Wang Y; Thomas M; Keats J; Xu Q; Rivera VM; Shakespeare WC; Clackson T; Dalgarno DC; Zhu X
    Chem Biol Drug Des; 2011 Jan; 77(1):1-11. PubMed ID: 21118377
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Pharmacological characteristics and clinical outcomes of ponatinib (Iclusig
    Yoshida T; Leen Liew E; Ota M; Nakayama H; Yanagihara Y; Nakamura Y; Seriu T; Kamishohara M
    Nihon Yakurigaku Zasshi; 2017; 150(1):54-61. PubMed ID: 28690276
    [No Abstract]   [Full Text] [Related]  

  • 17. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.
    Kesavan K; Lobel-Rice K; Sun W; Lapadat R; Webb S; Johnson GL; Garrington TP
    J Cell Physiol; 2004 Apr; 199(1):140-8. PubMed ID: 14978743
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.
    Li G; Lucas JJ; Gelfand EW
    Cell Immunol; 2005 Nov; 238(1):10-8. PubMed ID: 16430878
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7.
    Bouloc N; Large JM; Smiljanic E; Whalley D; Ansell KH; Edlin CD; Bryans JS
    Bioorg Med Chem Lett; 2008 Oct; 18(19):5294-8. PubMed ID: 18774709
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ponatinib (Iclusig) for CML and Ph+ ALL.
    Med Lett Drugs Ther; 2013 Sep; 55(1424):71-2. PubMed ID: 25970013
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 6.