BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 26056295)

  • 1. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.
    Huang SX; Yun BS; Ma M; Basu HS; Church DR; Ingenhorst G; Huang Y; Yang D; Lohman JR; Tang GL; Ju J; Liu T; Wilding G; Shen B
    Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8278-83. PubMed ID: 26056295
    [TBL] [Abstract][Full Text] [Related]  

  • 2. C-S bond cleavage by a polyketide synthase domain.
    Ma M; Lohman JR; Liu T; Shen B
    Proc Natl Acad Sci U S A; 2015 Aug; 112(33):10359-64. PubMed ID: 26240335
    [TBL] [Abstract][Full Text] [Related]  

  • 3. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.
    Kwong T; Ma M; Pan G; Hindra ; Yang D; Yang C; Lohman JR; Rudolf JD; Cleveland JL; Shen B
    Biochemistry; 2018 Aug; 57(33):5005-5013. PubMed ID: 30070831
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.
    Huang Y; Yang D; Pan G; Tang GL; Shen B
    Appl Microbiol Biotechnol; 2016 Dec; 100(24):10555-10562. PubMed ID: 27704182
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
    Liu T; Ma M; Ge HM; Yang C; Cleveland J; Shen B
    Bioorg Med Chem Lett; 2015 Nov; 25(21):4899-4902. PubMed ID: 26071634
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
    Cheng YQ; Tang GL; Shen B
    J Bacteriol; 2002 Dec; 184(24):7013-24. PubMed ID: 12446651
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.
    Keerthi K; Rajapakse A; Sun D; Gates KS
    Bioorg Med Chem; 2013 Jan; 21(1):235-41. PubMed ID: 23168080
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.
    Tang GL; Cheng YQ; Shen B
    Chem Biol; 2004 Jan; 11(1):33-45. PubMed ID: 15112993
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.
    Tang GL; Cheng YQ; Shen B
    J Nat Prod; 2006 Mar; 69(3):387-93. PubMed ID: 16562841
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Less than the sum of its parts, a leinamycin precursor has superior properties.
    Katt WP; Cerione RA
    Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8164-5. PubMed ID: 26106161
    [No Abstract]   [Full Text] [Related]  

  • 11. Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase.
    Meng S; Steele AD; Yan W; Pan G; Kalkreuter E; Liu YC; Xu Z; Shen B
    Nat Commun; 2021 Sep; 12(1):5672. PubMed ID: 34584078
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of Cryptic Largimycins in
    Becerril A; Pérez-Victoria I; Ye S; Braña AF; Martín J; Reyes F; Salas JA; Méndez C
    ACS Chem Biol; 2020 Jun; 15(6):1541-1553. PubMed ID: 32310633
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of the leinamycin family of natural products by mining actinobacterial genomes.
    Pan G; Xu Z; Guo Z; Hindra ; Ma M; Yang D; Zhou H; Gansemans Y; Zhu X; Huang Y; Zhao LX; Jiang Y; Cheng J; Van Nieuwerburgh F; Suh JW; Duan Y; Shen B
    Proc Natl Acad Sci U S A; 2017 Dec; 114(52):E11131-E11140. PubMed ID: 29229819
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis.
    Huang Y; Tang GL; Pan G; Chang CY; Shen B
    Org Lett; 2016 Sep; 18(17):4288-91. PubMed ID: 27541042
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
    Tang GL; Cheng YQ; Shen B
    J Biol Chem; 2007 Jul; 282(28):20273-82. PubMed ID: 17502372
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.
    Sivaramakrishnan S; Gates KS
    Bioorg Med Chem Lett; 2008 May; 18(10):3076-80. PubMed ID: 18068362
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides.
    Keerthi K; Gates KS
    Org Biomol Chem; 2007 May; 5(10):1595-600. PubMed ID: 17571189
    [TBL] [Abstract][Full Text] [Related]  

  • 18. DNA strand scission by the novel antitumor antibiotic leinamycin.
    Hara M; Saitoh Y; Nakano H
    Biochemistry; 1990 Jun; 29(24):5676-81. PubMed ID: 2383554
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sequence specificity of DNA alkylation by the antitumor natural product leinamycin.
    Zang H; Gates KS
    Chem Res Toxicol; 2003 Dec; 16(12):1539-46. PubMed ID: 14680367
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.
    Huang Y; Huang SX; Ju J; Tang G; Liu T; Shen B
    Org Lett; 2011 Feb; 13(3):498-501. PubMed ID: 21192727
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.