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7. Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome. Lynch SM; DeVicente J; Hermann JC; Jaime-Figueroa S; Jin S; Kuglstatter A; Li H; Lovey A; Menke J; Niu L; Patel V; Roy D; Soth M; Steiner S; Tivitmahaisoon P; Vu MD; Yee C Bioorg Med Chem Lett; 2013 May; 23(9):2793-800. PubMed ID: 23540648 [TBL] [Abstract][Full Text] [Related]
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9. Discovery of highly potent, selective, covalent inhibitors of JAK3. Kempson J; Ovalle D; Guo J; Wrobleski ST; Lin S; Spergel SH; Duan JJ; Jiang B; Lu Z; Das J; Yang BV; Hynes J; Wu H; Tokarski J; Sack JS; Khan J; Schieven G; Blatt Y; Chaudhry C; Salter-Cid LM; Fura A; Barrish JC; Carter PH; Pitts WJ Bioorg Med Chem Lett; 2017 Oct; 27(20):4622-4625. PubMed ID: 28927786 [TBL] [Abstract][Full Text] [Related]
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11. Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Duan JJ; Lu Z; Jiang B; Yang BV; Doweyko LM; Nirschl DS; Haque LE; Lin S; Brown G; Hynes J; Tokarski JS; Sack JS; Khan J; Lippy JS; Zhang RF; Pitt S; Shen G; Pitts WJ; Carter PH; Barrish JC; Nadler SG; Salter-Cid LM; McKinnon M; Fura A; Schieven GL; Wrobleski ST Bioorg Med Chem Lett; 2014 Dec; 24(24):5721-5726. PubMed ID: 25453808 [TBL] [Abstract][Full Text] [Related]
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15. Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors. Yamagishi H; Inoue T; Nakajima Y; Maeda J; Tominaga H; Usuda H; Hondo T; Moritomo A; Nakamori F; Ito M; Nakamura K; Morio H; Higashi Y; Inami M; Shirakami S Bioorg Med Chem; 2017 Oct; 25(20):5311-5326. PubMed ID: 28789911 [TBL] [Abstract][Full Text] [Related]
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20. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. Grimster NP; Anderson E; Alimzhanov M; Bebernitz G; Bell K; Chuaqui C; Deegan T; Ferguson AD; Gero T; Harsch A; Huszar D; Kawatkar A; Kettle JG; Lyne P; Read JA; Rivard Costa C; Ruston L; Schroeder P; Shi J; Su Q; Throner S; Toader D; Vasbinder M; Woessner R; Wang H; Wu A; Ye M; Zheng W; Zinda M J Med Chem; 2018 Jun; 61(12):5235-5244. PubMed ID: 29856615 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]