409 related articles for article (PubMed ID: 26085527)
1. The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Mol Cancer Res; 2015 Sep; 13(9):1265-73. PubMed ID: 26085527
[TBL] [Abstract][Full Text] [Related]
2. K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
Nussinov R; Muratcioglu S; Tsai CJ; Jang H; Gursoy A; Keskin O
Expert Opin Ther Targets; 2016 Jul; 20(7):831-42. PubMed ID: 26873344
[TBL] [Abstract][Full Text] [Related]
3. Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
Nussinov R; Zhang M; Tsai CJ; Jang H
Biochim Biophys Acta Mol Basis Dis; 2018 Jun; 1864(6 Pt B):2304-2314. PubMed ID: 29097261
[TBL] [Abstract][Full Text] [Related]
4. Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
Jang H; Banerjee A; Chavan T; Gaponenko V; Nussinov R
J Biol Chem; 2017 Jul; 292(30):12544-12559. PubMed ID: 28623230
[TBL] [Abstract][Full Text] [Related]
5. Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?
Nussinov R; Tsai CJ; Jang H
Semin Cancer Biol; 2019 Feb; 54():114-120. PubMed ID: 29307569
[TBL] [Abstract][Full Text] [Related]
6. Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
Li X; Dai J; Ni D; He X; Zhang H; Zhang J; Fu Q; Liu Y; Lu S
Int J Biol Macromol; 2020 Feb; 144():643-655. PubMed ID: 31816384
[TBL] [Abstract][Full Text] [Related]
7. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH
Zhang M; Jang H; Gaponenko V; Nussinov R
Biophys J; 2017 Nov; 113(9):1956-1967. PubMed ID: 29117520
[TBL] [Abstract][Full Text] [Related]
8. Calmodulin and PI3K Signaling in
Nussinov R; Wang G; Tsai CJ; Jang H; Lu S; Banerjee A; Zhang J; Gaponenko V
Trends Cancer; 2017 Mar; 3(3):214-224. PubMed ID: 28462395
[TBL] [Abstract][Full Text] [Related]
9. Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Nussinov R; Tsai CJ; Jang H
Cancer Res; 2018 Feb; 78(3):593-602. PubMed ID: 29273632
[TBL] [Abstract][Full Text] [Related]
10. The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin.
Abraham SJ; Nolet RP; Calvert RJ; Anderson LM; Gaponenko V
Biochemistry; 2009 Aug; 48(32):7575-83. PubMed ID: 19583261
[TBL] [Abstract][Full Text] [Related]
11. Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.
Muratcioglu S; Aydin C; Odabasi E; Ozdemir ES; Firat-Karalar EN; Jang H; Tsai CJ; Nussinov R; Kavakli IH; Gursoy A; Keskin O
J Mol Biol; 2020 Feb; 432(4):1199-1215. PubMed ID: 31931009
[TBL] [Abstract][Full Text] [Related]
12. Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.
Ni D; Liu D; Zhang J; Lu S
Int J Mol Sci; 2018 Jan; 19(1):. PubMed ID: 29300353
[TBL] [Abstract][Full Text] [Related]
13. Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.
Nussinov R; Tsai CJ; Muratcioglu S; Jang H; Gursoy A; Keskin O
Expert Rev Proteomics; 2015; 12(6):669-82. PubMed ID: 26496174
[TBL] [Abstract][Full Text] [Related]
14. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Mazhab-Jafari MT; Marshall CB; Smith MJ; Gasmi-Seabrook GM; Stathopulos PB; Inagaki F; Kay LE; Neel BG; Ikura M
Proc Natl Acad Sci U S A; 2015 May; 112(21):6625-30. PubMed ID: 25941399
[TBL] [Abstract][Full Text] [Related]
15. Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.
Villalonga P; López-Alcalá C; Bosch M; Chiloeches A; Rocamora N; Gil J; Marais R; Marshall CJ; Bachs O; Agell N
Mol Cell Biol; 2001 Nov; 21(21):7345-54. PubMed ID: 11585916
[TBL] [Abstract][Full Text] [Related]
16. Intrinsic protein disorder in oncogenic KRAS signaling.
Nussinov R; Jang H; Tsai CJ; Liao TJ; Li S; Fushman D; Zhang J
Cell Mol Life Sci; 2017 Sep; 74(17):3245-3261. PubMed ID: 28597297
[TBL] [Abstract][Full Text] [Related]
17. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.
Appleman VA; Ahronian LG; Cai J; Klimstra DS; Lewis BC
Mol Cancer Res; 2012 Sep; 10(9):1228-39. PubMed ID: 22871572
[TBL] [Abstract][Full Text] [Related]
18. Regulation of K-Ras4B Membrane Binding by Calmodulin.
Sperlich B; Kapoor S; Waldmann H; Winter R; Weise K
Biophys J; 2016 Jul; 111(1):113-22. PubMed ID: 27410739
[TBL] [Abstract][Full Text] [Related]
19. The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.
Banerjee A; Jang H; Nussinov R; Gaponenko V
Curr Opin Struct Biol; 2016 Feb; 36():10-7. PubMed ID: 26709496
[TBL] [Abstract][Full Text] [Related]
20. The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin.
Jang H; Banerjee A; Marcus K; Makowski L; Mattos C; Gaponenko V; Nussinov R
Structure; 2019 Nov; 27(11):1647-1659.e4. PubMed ID: 31495533
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]