141 related articles for article (PubMed ID: 26110200)
21. Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.
Kabiri Z; Numata A; Kawasaki A; Edison ; Tenen DG; Virshup DM
Blood; 2015 Aug; 126(9):1086-94. PubMed ID: 26089398
[TBL] [Abstract][Full Text] [Related]
22. Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.
Chen Q; Takada R; Takada S
J Cell Sci; 2012 May; 125(Pt 9):2224-34. PubMed ID: 22357957
[TBL] [Abstract][Full Text] [Related]
23. Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins.
Galli LM; Anderson MO; Gabriel Fraley J; Sanchez L; Bueno R; Hernandez DN; Maddox EU; Lingappa VR; Burrus LW
Open Biol; 2021 Jun; 11(6):200400. PubMed ID: 34186010
[TBL] [Abstract][Full Text] [Related]
24. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.
Xu Z; Xu X; O'Laoi R; Ma H; Zheng J; Chen S; Luo L; Hu Z; He S; Li J; Zhang H; Zhang X
Bioorg Med Chem; 2016 Nov; 24(22):5861-5872. PubMed ID: 27692509
[TBL] [Abstract][Full Text] [Related]
25. Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.
Biechele S; Cockburn K; Lanner F; Cox BJ; Rossant J
Development; 2013 Jul; 140(14):2961-71. PubMed ID: 23760955
[TBL] [Abstract][Full Text] [Related]
26. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Moon J; Zhou H; Zhang LS; Tan W; Liu Y; Zhang S; Morlock LK; Bao X; Palecek SP; Feng JQ; Williams NS; Amatruda JF; Olson EN; Bassel-Duby R; Lum L
Proc Natl Acad Sci U S A; 2017 Feb; 114(7):1649-1654. PubMed ID: 28143939
[TBL] [Abstract][Full Text] [Related]
27. Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
Ho SY; Alam J; Jeyaraj DA; Wang W; Lin GR; Ang SH; Tan ESW; Lee MA; Ke Z; Madan B; Virshup DM; Ding LJ; Manoharan V; Chew YS; Low CB; Pendharkar V; Sangthongpitag K; Hill J; Keller TH; Poulsen A
J Med Chem; 2017 Aug; 60(15):6678-6692. PubMed ID: 28671458
[TBL] [Abstract][Full Text] [Related]
28. Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.
Yu J; Liao PJ; Xu W; Jones JR; Everman DB; Flanagan-Steet H; Keller TH; Virshup DM
J Cell Sci; 2021 Dec; 134(24):. PubMed ID: 34817055
[TBL] [Abstract][Full Text] [Related]
29. Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Liu Y; Qi X; Donnelly L; Elghobashi-Meinhardt N; Long T; Zhou RW; Sun Y; Wang B; Li X
Nature; 2022 Jul; 607(7920):816-822. PubMed ID: 35831507
[TBL] [Abstract][Full Text] [Related]
30. Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.
Galli LM; Zebarjadi N; Li L; Lingappa VR; Burrus LW
Exp Cell Res; 2016 Sep; 347(1):171-183. PubMed ID: 27492485
[TBL] [Abstract][Full Text] [Related]
31. Spatial and temporal expression of PORCN is highly dynamic in the developing mouse cochlea.
Oliver BL; Young CA; Munnamalai V
Gene Expr Patterns; 2021 Dec; 42():119214. PubMed ID: 34547456
[TBL] [Abstract][Full Text] [Related]
32. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Kulak O; Chen H; Holohan B; Wu X; He H; Borek D; Otwinowski Z; Yamaguchi K; Garofalo LA; Ma Z; Wright W; Chen C; Shay JW; Zhang X; Lum L
Mol Cell Biol; 2015 Jul; 35(14):2425-35. PubMed ID: 25939383
[TBL] [Abstract][Full Text] [Related]
33. Application of porcupine inhibitors in stem cell fate determination.
Kalantary-Charvadeh A; Hosseini V; Mehdizadeh A; Darabi M
Chem Biol Drug Des; 2020 Oct; 96(4):1052-1068. PubMed ID: 32419352
[TBL] [Abstract][Full Text] [Related]
34. The porcupine inhibitor WNT974 provokes ectodermal lineage differentiation of human embryonic stem cells.
Kalantary-Charvadeh A; Hosseini V; Mehdizadeh A; Nazari Soltan Ahmad S; Rahbarghazi R; Nozad Charoudeh H; Nouri M; Darabi M
Cell Biochem Funct; 2022 Jun; 40(4):359-368. PubMed ID: 35445405
[TBL] [Abstract][Full Text] [Related]
35. Modulating Wnt signaling at the root: Porcupine and Wnt acylation.
Torres VI; Godoy JA; Inestrosa NC
Pharmacol Ther; 2019 Jun; 198():34-45. PubMed ID: 30790642
[TBL] [Abstract][Full Text] [Related]
36. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.
Madan B; Ke Z; Lei ZD; Oliver FA; Oshima M; Lee MA; Rozen S; Virshup DM
Oncotarget; 2016 Mar; 7(11):12386-92. PubMed ID: 26848981
[TBL] [Abstract][Full Text] [Related]
37. PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
Covey TM; Kaur S; Tan Ong T; Proffitt KD; Wu Y; Tan P; Virshup DM
PLoS One; 2012; 7(4):e34532. PubMed ID: 22509316
[TBL] [Abstract][Full Text] [Related]
38. Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos.
Biechele S; Cox BJ; Rossant J
Dev Biol; 2011 Jul; 355(2):275-85. PubMed ID: 21554866
[TBL] [Abstract][Full Text] [Related]
39. Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling.
Chen CW; Beyer C; Liu J; Maier C; Li C; Trinh-Minh T; Xu X; Cole SH; Hsieh MH; Ng N; Althage A; Meeusen S; Pan S; Svensson EC; Seidel HM; Schett G; Gergely P; Harris JL; Distler JH
Ann Rheum Dis; 2017 Apr; 76(4):773-778. PubMed ID: 28153829
[TBL] [Abstract][Full Text] [Related]
40. Wnt addiction of genetically defined cancers reversed by PORCN inhibition.
Madan B; Ke Z; Harmston N; Ho SY; Frois AO; Alam J; Jeyaraj DA; Pendharkar V; Ghosh K; Virshup IH; Manoharan V; Ong EH; Sangthongpitag K; Hill J; Petretto E; Keller TH; Lee MA; Matter A; Virshup DM
Oncogene; 2016 Apr; 35(17):2197-207. PubMed ID: 26257057
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]