BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 26113188)

  • 21. Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.
    Kadoh Y; Miyoshi H; Matsumura T; Tanaka Y; Hongu M; Kimura M; Takedomi K; Omori K; Kotera J; Sasaki T; Kobayashi T; Taniguchi H; Watanabe Y; Kojima K; Sakamoto T; Himiyama T; Kawanishi E
    Chem Pharm Bull (Tokyo); 2018; 66(3):243-250. PubMed ID: 29491258
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.
    Hamaguchi W; Masuda N; Miyamoto S; Shiina Y; Kikuchi S; Mihara T; Moriguchi H; Fushiki H; Murakami Y; Amano Y; Honbou K; Hattori K
    Bioorg Med Chem; 2015 Jan; 23(2):297-313. PubMed ID: 25515954
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
    Hu E; Kunz RK; Rumfelt S; Chen N; Bürli R; Li C; Andrews KL; Zhang J; Chmait S; Kogan J; Lindstrom M; Hitchcock SA; Treanor J
    Bioorg Med Chem Lett; 2012 Mar; 22(6):2262-5. PubMed ID: 22365755
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
    Shipe WD; Sharik SS; Barrow JC; McGaughey GB; Theberge CR; Uslaner JM; Yan Y; Renger JJ; Smith SM; Coleman PJ; Cox CD
    J Med Chem; 2015 Oct; 58(19):7888-94. PubMed ID: 26378882
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.
    Rzasa RM; Hu E; Rumfelt S; Chen N; Andrews KL; Chmait S; Falsey JR; Zhong W; Jones AD; Porter A; Louie SW; Zhao X; Treanor JJ; Allen JR
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7371-5. PubMed ID: 23149228
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia.
    Cutshall NS; Onrust R; Rohde A; Gragerov S; Hamilton L; Harbol K; Shen HR; McKee S; Zuta C; Gragerova G; Florio V; Wheeler TN; Gage JL
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5595-9. PubMed ID: 22841436
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.
    Chino A; Masuda N; Amano Y; Honbou K; Mihara T; Yamazaki M; Tomishima M
    Bioorg Med Chem; 2014 Jul; 22(13):3515-26. PubMed ID: 24837154
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.
    Helal CJ; Kang Z; Hou X; Pandit J; Chappie TA; Humphrey JM; Marr ES; Fennell KF; Chenard LK; Fox C; Schmidt CJ; Williams RD; Chapin DS; Siuciak J; Lebel L; Menniti F; Cianfrogna J; Fonseca KR; Nelson FR; O'Connor R; MacDougall M; McDowell L; Liras S
    J Med Chem; 2011 Jul; 54(13):4536-47. PubMed ID: 21650160
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines.
    Wagner S; Scheunemann M; Dipper K; Egerland U; Hoefgen N; Steinbach J; Brust P
    Eur J Med Chem; 2016 Jan; 107():97-108. PubMed ID: 26562545
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
    Höfgen N; Stange H; Schindler R; Lankau HJ; Grunwald C; Langen B; Egerland U; Tremmel P; Pangalos MN; Marquis KL; Hage T; Harrison BL; Malamas MS; Brandon NJ; Kronbach T
    J Med Chem; 2010 Jun; 53(11):4399-411. PubMed ID: 20450197
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.
    Geneste H; Drescher K; Jakob C; Laplanche L; Ochse M; Torrent M
    Bioorg Med Chem Lett; 2019 Feb; 29(3):406-412. PubMed ID: 30587449
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.
    Sikora J; Podsiedlik M; Pietras T; Kosmalski M; Matłoka M; Moszczyński-Petkowski R; Wieczorek M; Markowicz-Piasecka M
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1743-1750. PubMed ID: 32938236
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Selectivity mechanism of phosphodiesterase isoform inhibitor through in silico investigations.
    Huang J; Hu B; Xu Z; Ye Y; Wang H; Wang S; Liu Z; Wang J
    J Mol Model; 2021 Dec; 28(1):9. PubMed ID: 34907481
    [TBL] [Abstract][Full Text] [Related]  

  • 34. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening.
    Fan HT; Guo JF; Zhang YX; Gu YX; Ning ZQ; Qiao YJ; Wang X
    Mol Med Rep; 2018 Jan; 17(1):388-393. PubMed ID: 29115449
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.
    Wang Y; Ke H
    Adv Neurobiol; 2017; 17():463-471. PubMed ID: 28956343
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Homology modeling, docking studies and molecular dynamic simulations using graphical processing unit architecture to probe the type-11 phosphodiesterase catalytic site: a computational approach for the rational design of selective inhibitors.
    Cichero E; D'Ursi P; Moscatelli M; Bruno O; Orro A; Rotolo C; Milanesi L; Fossa P
    Chem Biol Drug Des; 2013 Dec; 82(6):718-31. PubMed ID: 23865680
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.
    Hamaguchi W; Masuda N; Miyamoto S; Kikuchi S; Narazaki F; Shiina Y; Seo R; Amano Y; Mihara T; Moriguchi H; Hattori K
    Bioorg Med Chem; 2015 Jul; 23(13):3351-67. PubMed ID: 25960322
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.
    Hamaguchi W; Masuda N; Isomura M; Miyamoto S; Kikuchi S; Amano Y; Honbou K; Mihara T; Watanabe T
    Bioorg Med Chem; 2013 Dec; 21(24):7612-23. PubMed ID: 24238902
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Fragment- and negative image-based screening of phosphodiesterase 10A inhibitors.
    Jokinen EM; Postila PA; Ahinko M; Niinivehmas S; Pentikäinen OT
    Chem Biol Drug Des; 2019 Oct; 94(4):1799-1812. PubMed ID: 31260165
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.
    Chappie TA; Humphrey JM; Allen MP; Estep KG; Fox CB; Lebel LA; Liras S; Marr ES; Menniti FS; Pandit J; Schmidt CJ; Tu M; Williams RD; Yang FV
    J Med Chem; 2007 Jan; 50(2):182-5. PubMed ID: 17228859
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.