245 related articles for article (PubMed ID: 26117823)
1. The study of dual COX-2/5-LOX inhibitors by using electronic-topological approach based on data on the ligand-receptor interactions.
Aksakal F; Shvets N; Dimoglo A
J Mol Graph Model; 2015 Jul; 60():79-88. PubMed ID: 26117823
[TBL] [Abstract][Full Text] [Related]
2. Structural and Electronic Factors Influencing the Selective Inhibition of COX-2.
Aksakal F; Shvets N; Khairullina V; Dimoglo A
Mini Rev Med Chem; 2016; 16(7):579-94. PubMed ID: 26471968
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Özadalı K; Özkanlı F; Jain S; Rao PP; Velázquez-Martínez CA
Bioorg Med Chem; 2012 May; 20(9):2912-22. PubMed ID: 22475926
[TBL] [Abstract][Full Text] [Related]
4. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
Zheng M; Zhang Z; Zhu W; Liu H; Luo X; Chen K; Jiang H
Bioorg Med Chem; 2006 May; 14(10):3428-37. PubMed ID: 16458008
[TBL] [Abstract][Full Text] [Related]
5. Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS.
Xie L; Lee DY; Shang Y; Cao X; Wang S; Liao J; Zhang T; Dai R
Phytomedicine; 2020 Oct; 77():153284. PubMed ID: 32707371
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Shen FQ; Wang ZC; Wu SY; Ren SZ; Man RJ; Wang BZ; Zhu HL
Bioorg Med Chem Lett; 2017 Aug; 27(16):3653-3660. PubMed ID: 28720504
[TBL] [Abstract][Full Text] [Related]
8. Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.
Lamie PF; Ali WAM; Bazgier V; Rárová L
Eur J Med Chem; 2016 Nov; 123():803-813. PubMed ID: 27541263
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors.
Lamie PF; Philoppes JN; Rárová L
Arch Pharm (Weinheim); 2018 Apr; 351(3-4):e1700311. PubMed ID: 29400411
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: In vitro and in silico studies.
Theoduloz C; Alzate-Morales J; Jiménez-Aspee F; Isla MI; Alberto MR; Pertino MW; Schmeda-Hirschmann G
Chem Biol Drug Des; 2019 Mar; 93(3):290-299. PubMed ID: 30294891
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Tan CM; Chen GS; Chen CS; Chang PT; Chern JW
Bioorg Med Chem; 2011 Nov; 19(21):6316-28. PubMed ID: 21958737
[TBL] [Abstract][Full Text] [Related]
13. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
Li Y; Chen SH; Ou TM; Tan JH; Li D; Gu LQ; Huang ZS
Bioorg Med Chem; 2011 Mar; 19(6):2074-83. PubMed ID: 21349729
[TBL] [Abstract][Full Text] [Related]
14. Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition.
Sadiq A; Mahnashi MH; Alyami BA; Alqahtani YS; Alqarni AO; Rashid U
Bioorg Chem; 2021 Jul; 112():104969. PubMed ID: 34023639
[TBL] [Abstract][Full Text] [Related]
15. Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Ghanim AM; Rezq S; Ibrahim TS; Romero DG; Kothayer H
Eur J Med Chem; 2021 Jul; 219():113457. PubMed ID: 33892270
[TBL] [Abstract][Full Text] [Related]
16. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Maghraby MT; Abou-Ghadir OMF; Abdel-Moty SG; Ali AY; Salem OIA
Bioorg Med Chem; 2020 Apr; 28(7):115403. PubMed ID: 32127262
[TBL] [Abstract][Full Text] [Related]
17. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX.
Omar YM; Abdu-Allah HHM; Abdel-Moty SG
Bioorg Chem; 2018 Oct; 80():461-471. PubMed ID: 29986191
[TBL] [Abstract][Full Text] [Related]
18. Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
Cai H; Huang X; Xu S; Shen H; Zhang P; Huang Y; Jiang J; Sun Y; Jiang B; Wu X; Yao H; Xu J
Eur J Med Chem; 2016 Jan; 108():89-103. PubMed ID: 26638042
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.
Abdelrahman MH; Youssif BGM; Abdelgawad MA; Abdelazeem AH; Ibrahim HM; Moustafa AEGA; Treamblu L; Bukhari SNA
Eur J Med Chem; 2017 Feb; 127():972-985. PubMed ID: 27837994
[TBL] [Abstract][Full Text] [Related]
20. Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities.
Khoshneviszadeh M; Shahraki O; Khoshneviszadeh M; Foroumadi A; Firuzi O; Edraki N; Nadri H; Moradi A; Shafiee A; Miri R
J Enzyme Inhib Med Chem; 2016 Dec; 31(6):1602-11. PubMed ID: 27028154
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
