BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

873 related articles for article (PubMed ID: 26118643)

  • 1. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.
    Egan DF; Chun MG; Vamos M; Zou H; Rong J; Miller CJ; Lou HJ; Raveendra-Panickar D; Yang CC; Sheffler DJ; Teriete P; Asara JM; Turk BE; Cosford ND; Shaw RJ
    Mol Cell; 2015 Jul; 59(2):285-97. PubMed ID: 26118643
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
    Ren H; Bakas NA; Vamos M; Chaikuad A; Limpert AS; Wimer CD; Brun SN; Lambert LJ; Tautz L; Celeridad M; Sheffler DJ; Knapp S; Shaw RJ; Cosford NDP
    J Med Chem; 2020 Dec; 63(23):14609-14625. PubMed ID: 33200929
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI-0206965.
    Lu J; Zhu L; Zheng LP; Cui Q; Zhu HH; Zhao H; Shen ZJ; Dong HY; Chen SS; Wu WZ; Tan JM
    EBioMedicine; 2018 Aug; 34():85-93. PubMed ID: 30078736
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small-molecule inhibitors: bULKing up mTOR inhibition.
    Goodwin JM; Murphy LO
    Nat Chem Biol; 2015 Oct; 11(10):758-60. PubMed ID: 26379023
    [No Abstract]   [Full Text] [Related]  

  • 5. Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma.
    Dower CM; Bhat N; Gebru MT; Chen L; Wills CA; Miller BA; Wang HG
    Mol Cancer Ther; 2018 Nov; 17(11):2365-2376. PubMed ID: 30166400
    [TBL] [Abstract][Full Text] [Related]  

  • 6. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.
    Chan EY; Kir S; Tooze SA
    J Biol Chem; 2007 Aug; 282(35):25464-74. PubMed ID: 17595159
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.
    Bach M; Larance M; James DE; Ramm G
    Biochem J; 2011 Dec; 440(2):283-91. PubMed ID: 21819378
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The association of AMPK with ULK1 regulates autophagy.
    Lee JW; Park S; Takahashi Y; Wang HG
    PLoS One; 2010 Nov; 5(11):e15394. PubMed ID: 21072212
    [TBL] [Abstract][Full Text] [Related]  

  • 9. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
    Kim J; Kundu M; Viollet B; Guan KL
    Nat Cell Biol; 2011 Feb; 13(2):132-41. PubMed ID: 21258367
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NPM1 mutant maintains ULK1 protein stability via TRAF6-dependent ubiquitination to promote autophagic cell survival in leukemia.
    Tang Y; Tao Y; Wang L; Yang L; Jing Y; Jiang X; Lei L; Yang Z; Wang X; Peng M; Xiao Q; Ren J; Zhang L
    FASEB J; 2021 Feb; 35(2):e21192. PubMed ID: 33201521
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR.
    Egan D; Kim J; Shaw RJ; Guan KL
    Autophagy; 2011 Jun; 7(6):643-4. PubMed ID: 21460621
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965.
    Ahwazi D; Neopane K; Markby GR; Kopietz F; Ovens AJ; Dall M; Hassing AS; Gräsle P; Alshuweishi Y; Treebak JT; Salt IP; Göransson O; Zeqiraj E; Scott JW; Sakamoto K
    Biochem J; 2021 Aug; 478(15):2977-2997. PubMed ID: 34259310
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge.
    Kandadi MR; Hu N; Ren J
    Curr Pharm Des; 2013; 19(27):4874-87. PubMed ID: 23448468
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3.
    Ji X; Zhang X; Li Z
    FEBS Open Bio; 2020 Nov; 10(11):2452-2463. PubMed ID: 33040463
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Autophagy-Initiating Protein Kinase ULK1 Phosphorylates Human Cytomegalovirus Tegument Protein pp28 and Regulates Efficient Virus Release.
    König P; Svrlanska A; Read C; Feichtinger S; Stamminger T
    J Virol; 2021 Feb; 95(6):. PubMed ID: 33328309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.
    Aryal P; Kim K; Park PH; Ham S; Cho J; Song K
    FEBS J; 2014 Oct; 281(20):4644-58. PubMed ID: 25132405
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.
    Lazarus MB; Novotny CJ; Shokat KM
    ACS Chem Biol; 2015 Jan; 10(1):257-61. PubMed ID: 25551253
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: a vital component of autophagy.
    Randhawa R; Sehgal M; Singh TR; Duseja A; Changotra H
    Gene; 2015 May; 562(1):40-9. PubMed ID: 25701603
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.
    Park JM; Seo M; Jung CH; Grunwald D; Stone M; Otto NM; Toso E; Ahn Y; Kyba M; Griffin TJ; Higgins L; Kim DH
    Autophagy; 2018; 14(4):584-597. PubMed ID: 29313410
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.
    Kraft C; Kijanska M; Kalie E; Siergiejuk E; Lee SS; Semplicio G; Stoffel I; Brezovich A; Verma M; Hansmann I; Ammerer G; Hofmann K; Tooze S; Peter M
    EMBO J; 2012 Sep; 31(18):3691-703. PubMed ID: 22885598
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 44.