BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 26119278)

  • 1. Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors.
    Schmitz J; Furtmann N; Ponert M; Frizler M; Löser R; Bartz U; Bajorath J; Gütschow M
    ChemMedChem; 2015 Aug; 10(8):1365-77. PubMed ID: 26119278
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.
    Frizler M; Schmitz J; Schulz-Fincke AC; Gütschow M
    J Med Chem; 2012 Jun; 55(12):5982-6. PubMed ID: 22686657
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases.
    Löser R; Gütschow M
    J Enzyme Inhib Med Chem; 2009 Dec; 24(6):1245-52. PubMed ID: 19912058
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
    Löser R; Schilling K; Dimmig E; Gütschow M
    J Med Chem; 2005 Dec; 48(24):7688-707. PubMed ID: 16302809
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Highly selective azadipeptide nitrile inhibitors for cathepsin K: design, synthesis and activity assays.
    Ren XF; Li HW; Fang X; Wu Y; Wang L; Zou S
    Org Biomol Chem; 2013 Feb; 11(7):1143-8. PubMed ID: 23299878
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
    Borišek J; Vizovišek M; Sosnowski P; Turk B; Turk D; Mohar B; Novič M
    J Med Chem; 2015 Sep; 58(17):6928-37. PubMed ID: 26280490
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fluorescent nitrile-based inhibitors of cysteine cathepsins.
    Frizler M; Mertens MD; Gütschow M
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7715-8. PubMed ID: 23122525
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.
    Schirmeister T; Schmitz J; Jung S; Schmenger T; Krauth-Siegel RL; Gütschow M
    Bioorg Med Chem Lett; 2017 Jan; 27(1):45-50. PubMed ID: 27890381
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A comparative study of warheads for design of cysteine protease inhibitors.
    Silva DG; Ribeiro JFR; De Vita D; Cianni L; Franco CH; Freitas-Junior LH; Moraes CB; Rocha JR; Burtoloso ACB; Kenny PW; Leitão A; Montanari CA
    Bioorg Med Chem Lett; 2017 Nov; 27(22):5031-5035. PubMed ID: 29054358
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
    Altmann E; Cowan-Jacob SW; Missbach M
    J Med Chem; 2004 Nov; 47(24):5833-6. PubMed ID: 15537340
    [TBL] [Abstract][Full Text] [Related]  

  • 11. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization.
    Lemke C; Cianni L; Feldmann C; Gilberg E; Yin J; Dos Reis Rocho F; de Vita D; Bartz U; Bajorath J; Montanari CA; Gütschow M
    Bioorg Med Chem Lett; 2020 Sep; 30(18):127420. PubMed ID: 32763808
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.
    Falgueyret JP; Oballa RM; Okamoto O; Wesolowski G; Aubin Y; Rydzewski RM; Prasit P; Riendeau D; Rodan SB; Percival MD
    J Med Chem; 2001 Jan; 44(1):94-104. PubMed ID: 11141092
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins.
    Behring L; Ruiz-Gómez G; Trapp C; Morales M; Wodtke R; Köckerling M; Kopka K; Pisabarro MT; Pietzsch J; Löser R
    J Med Chem; 2023 Mar; 66(6):3818-3851. PubMed ID: 36867428
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors.
    Ehmke V; Quinsaat JE; Rivera-Fuentes P; Heindl C; Freymond C; Rottmann M; Brun R; Schirmeister T; Diederich F
    Org Biomol Chem; 2012 Aug; 10(30):5764-8. PubMed ID: 22336919
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dipeptide nitrile inhibitors of cathepsin K.
    Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Lattmann R; Missbach M
    Bioorg Med Chem Lett; 2006 May; 16(9):2549-54. PubMed ID: 16480867
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.
    Di Chio C; Previti S; Amendola G; Ravichandran R; Wagner A; Cosconati S; Hellmich UA; Schirmeister T; Zappalà M; Ettari R
    Eur J Med Chem; 2022 Jun; 236():114328. PubMed ID: 35385806
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
    Greenspan PD; Clark KL; Tommasi RA; Cowen SD; McQuire LW; Farley DL; van Duzer JH; Goldberg RL; Zhou H; Du Z; Fitt JJ; Coppa DE; Fang Z; Macchia W; Zhu L; Capparelli MP; Goldstein R; Wigg AM; Doughty JR; Bohacek RS; Knap AK
    J Med Chem; 2001 Dec; 44(26):4524-34. PubMed ID: 11741472
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.
    Ehmke V; Winkler E; Banner DW; Haap W; Schweizer WB; Rottmann M; Kaiser M; Freymond C; Schirmeister T; Diederich F
    ChemMedChem; 2013 Jun; 8(6):967-75. PubMed ID: 23658062
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
    Ward YD; Thomson DS; Frye LL; Cywin CL; Morwick T; Emmanuel MJ; Zindell R; McNeil D; Bekkali Y; Girardot M; Hrapchak M; DeTuri M; Crane K; White D; Pav S; Wang Y; Hao MH; Grygon CA; Labadia ME; Freeman DM; Davidson W; Hopkins JL; Brown ML; Spero DM
    J Med Chem; 2002 Dec; 45(25):5471-82. PubMed ID: 12459015
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
    Ribeiro JFR; Cianni L; Li C; Warwick TG; de Vita D; Rosini F; Dos Reis Rocho F; Martins FCP; Kenny PW; Lameira J; Leitão A; Emsley J; Montanari CA
    Bioorg Med Chem; 2020 Nov; 28(22):115743. PubMed ID: 33038787
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.