199 related articles for article (PubMed ID: 26124156)
1. Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).
Armstrong CM; Meyers DJ; Imlay LS; Freel Meyers C; Odom AR
Antimicrob Agents Chemother; 2015 Sep; 59(9):5511-9. PubMed ID: 26124156
[TBL] [Abstract][Full Text] [Related]
2. Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.
McKenney ES; Sargent M; Khan H; Uh E; Jackson ER; San Jose G; Couch RD; Dowd CS; van Hoek ML
PLoS One; 2012; 7(10):e38167. PubMed ID: 23077474
[TBL] [Abstract][Full Text] [Related]
3. A computational study of the molecular basis of antibiotic resistance in a DXR mutant.
Krebs FS; Esque J; Stote RH
J Comput Aided Mol Des; 2019 Oct; 33(10):927-940. PubMed ID: 31654265
[TBL] [Abstract][Full Text] [Related]
4. Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
Brown AC; Parish T
BMC Microbiol; 2008 May; 8():78. PubMed ID: 18489786
[TBL] [Abstract][Full Text] [Related]
5. A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.
Zhang B; Watts KM; Hodge D; Kemp LM; Hunstad DA; Hicks LM; Odom AR
Biochemistry; 2011 May; 50(17):3570-7. PubMed ID: 21438569
[TBL] [Abstract][Full Text] [Related]
6. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
Humnabadkar V; Jha RK; Ghatnekar N; De Sousa SM
J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
[TBL] [Abstract][Full Text] [Related]
7. α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues.
Dreneau A; Krebs FS; Munier M; Ngov C; Tritsch D; Lièvremont D; Rohmer M; Grosdemange-Billiard C
Molecules; 2021 Aug; 26(16):. PubMed ID: 34443699
[TBL] [Abstract][Full Text] [Related]
8. Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.
San Jose G; Jackson ER; Haymond A; Johny C; Edwards RL; Wang X; Brothers RC; Edelstein EK; Odom AR; Boshoff HI; Couch RD; Dowd CS
ACS Infect Dis; 2016 Dec; 2(12):923-935. PubMed ID: 27676224
[TBL] [Abstract][Full Text] [Related]
9. Reverse
Abdullaziz MA; Takada S; Illarionov B; Pessanha de Carvalho L; Sakamoto Y; Höfmann S; Knak T; Kiffe-Delf AL; Mazzone F; Pfeffer K; Kalscheuer R; Bacher A; Held J; Fischer M; Tanaka N; Kurz T
ACS Infect Dis; 2024 May; 10(5):1739-1752. PubMed ID: 38647213
[TBL] [Abstract][Full Text] [Related]
10. Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Woo YH; Fernandes RP; Proteau PJ
Bioorg Med Chem; 2006 Apr; 14(7):2375-85. PubMed ID: 16310360
[TBL] [Abstract][Full Text] [Related]
11. Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity.
Wiesner J; Ortmann R; Jomaa H; Schlitzer M
Arch Pharm (Weinheim); 2007 Dec; 340(12):667-9. PubMed ID: 17994601
[TBL] [Abstract][Full Text] [Related]
12. Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli.
Pines G; Oh EJ; Bassalo MC; Choudhury A; Garst AD; Fankhauser RG; Eckert CA; Gill RT
ACS Synth Biol; 2018 Dec; 7(12):2824-2832. PubMed ID: 30462485
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Chofor R; Sooriyaarachchi S; Risseeuw MD; Bergfors T; Pouyez J; Johny C; Haymond A; Everaert A; Dowd CS; Maes L; Coenye T; Alex A; Couch RD; Jones TA; Wouters J; Mowbray SL; Van Calenbergh S
J Med Chem; 2015 Apr; 58(7):2988-3001. PubMed ID: 25781377
[TBL] [Abstract][Full Text] [Related]
14. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
Dhiman RK; Schaeffer ML; Bailey AM; Testa CA; Scherman H; Crick DC
J Bacteriol; 2005 Dec; 187(24):8395-402. PubMed ID: 16321944
[TBL] [Abstract][Full Text] [Related]
15. Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.
Slade JA; Brockett M; Singh R; Liechti GW; Maurelli AT
PLoS Pathog; 2019 Oct; 15(10):e1008078. PubMed ID: 31622442
[TBL] [Abstract][Full Text] [Related]
16. [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives].
Shtannikov AV; Sergeeva EE; Biketov SF; Ostrovskiĭ DN
Antibiot Khimioter; 2007; 52(7-8):3-9. PubMed ID: 18986018
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Andaloussi M; Henriksson LM; Więckowska A; Lindh M; Björkelid C; Larsson AM; Suresh S; Iyer H; Srinivasa BR; Bergfors T; Unge T; Mowbray SL; Larhed M; Jones TA; Karlén A
J Med Chem; 2011 Jul; 54(14):4964-76. PubMed ID: 21678907
[TBL] [Abstract][Full Text] [Related]
18. N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR.
Gadakh B; Pouyez J; Wouters J; Venkatesham A; Cos P; Van Aerschot A
Bioorg Med Chem Lett; 2015 Apr; 25(7):1577-9. PubMed ID: 25726328
[TBL] [Abstract][Full Text] [Related]
19. Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.
Courtens C; Risseeuw M; Caljon G; Maes L; Martin A; Van Calenbergh S
Bioorg Med Chem; 2019 Mar; 27(5):729-747. PubMed ID: 30692024
[TBL] [Abstract][Full Text] [Related]
20. Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
Ponaire S; Zinglé C; Tritsch D; Grosdemange-Billiard C; Rohmer M
Eur J Med Chem; 2012 May; 51():277-85. PubMed ID: 22405649
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]