339 related articles for article (PubMed ID: 26149921)
1. Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains.
Liu G; Chen M; Mi N; Yang W; Li X; Wang P; Yin N; Li Y; Yue F; Chan P; Yu S
Neurobiol Aging; 2015 Sep; 36(9):2649-59. PubMed ID: 26149921
[TBL] [Abstract][Full Text] [Related]
2. Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.
Chen M; Yang W; Li X; Li X; Wang P; Yue F; Yang H; Chan P; Yu S
Oncotarget; 2016 Feb; 7(8):8466-80. PubMed ID: 27032368
[TBL] [Abstract][Full Text] [Related]
3. Increased α-synuclein oligomerization is associated with decreased activity of glucocerebrosidase in the aging human striatum and hippocampus.
Yang W; Li X; Yin N
Neurosci Lett; 2020 Aug; 733():135093. PubMed ID: 32470554
[TBL] [Abstract][Full Text] [Related]
4. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
Mazzulli JR; Zunke F; Tsunemi T; Toker NJ; Jeon S; Burbulla LF; Patnaik S; Sidransky E; Marugan JJ; Sue CM; Krainc D
J Neurosci; 2016 Jul; 36(29):7693-706. PubMed ID: 27445146
[TBL] [Abstract][Full Text] [Related]
5. Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains.
Yang W; Li X; Li X; Li X; Yu S
Oncotarget; 2016 Feb; 7(7):7441-54. PubMed ID: 26824991
[TBL] [Abstract][Full Text] [Related]
6. Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity.
Yang J; Hertz E; Zhang X; Leinartaité L; Lundius EG; Li J; Svenningsson P
Neurosci Lett; 2016 Jan; 611():51-8. PubMed ID: 26610904
[TBL] [Abstract][Full Text] [Related]
7. The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity.
Wang Y; Liu J; Chen M; Du T; Duan C; Gao G; Yang H
Int J Biochem Cell Biol; 2016 Jun; 75():34-44. PubMed ID: 27012437
[TBL] [Abstract][Full Text] [Related]
8. Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex.
Yang W; Wang X; Duan C; Lu L; Yang H
Neurochem Int; 2013 Sep; 63(3):180-94. PubMed ID: 23796501
[TBL] [Abstract][Full Text] [Related]
9. In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain.
Bergeron M; Motter R; Tanaka P; Fauss D; Babcock M; Chiou SS; Nelson S; San Pablo F; Anderson JP
Neuroscience; 2014 Jan; 256():72-82. PubMed ID: 24128992
[TBL] [Abstract][Full Text] [Related]
10. Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.
Wu J; Lou H; Alerte TN; Stachowski EK; Chen J; Singleton AB; Hamilton RL; Perez RG
Neuroscience; 2012 Apr; 207():288-97. PubMed ID: 22326202
[TBL] [Abstract][Full Text] [Related]
11. Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.
Gegg ME; Verona G; Schapira AHV
Hum Mol Genet; 2020 Jun; 29(10):1716-1728. PubMed ID: 32391886
[TBL] [Abstract][Full Text] [Related]
12. Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys.
Li X; Yang W; Li X; Chen M; Liu C; Yu S
Neurosci Lett; 2018 Jan; 662():276-282. PubMed ID: 29107086
[TBL] [Abstract][Full Text] [Related]
13. Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice.
Chen M; Liu J; Lu Y; Duan C; Lu L; Gao G; Chan P; Yu S; Yang H
J Neural Transm (Vienna); 2017 Apr; 124(4):441-453. PubMed ID: 27904950
[TBL] [Abstract][Full Text] [Related]
14. Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.
Vaikath NN; Erskine D; Morris CM; Majbour NK; Vekrellis K; Li JY; El-Agnaf OMA
Neuropathol Appl Neurobiol; 2019 Oct; 45(6):597-608. PubMed ID: 30422353
[TBL] [Abstract][Full Text] [Related]
15. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.
Yan R; Zhang J; Park HJ; Park ES; Oh S; Zheng H; Junn E; Voronkov M; Stock JB; Mouradian MM
Proc Natl Acad Sci U S A; 2018 Dec; 115(51):E12053-E12062. PubMed ID: 30509990
[TBL] [Abstract][Full Text] [Related]
16. Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Rocha EM; Smith GA; Park E; Cao H; Graham AR; Brown E; McLean JR; Hayes MA; Beagan J; Izen SC; Perez-Torres E; Hallett PJ; Isacson O
Antioxid Redox Signal; 2015 Aug; 23(6):550-64. PubMed ID: 26094487
[TBL] [Abstract][Full Text] [Related]
17. Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.
Blanz J; Saftig P
J Neurochem; 2016 Oct; 139 Suppl 1():198-215. PubMed ID: 26860955
[TBL] [Abstract][Full Text] [Related]
18. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.
Rocha EM; Smith GA; Park E; Cao H; Brown E; Hayes MA; Beagan J; McLean JR; Izen SC; Perez-Torres E; Hallett PJ; Isacson O
Neurobiol Dis; 2015 Oct; 82():495-503. PubMed ID: 26392287
[TBL] [Abstract][Full Text] [Related]
19. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Cosden M; Jinn S; Yao L; Gretzula CA; Kandebo M; Toolan D; Hatcher NG; Ma L; Lemaire W; Adam GC; Burlein C; Minnick C; Flick R; Watt ML; Mulhearn J; Fraley M; Drolet RE; Marcus JN; Smith SM
Neurobiol Dis; 2021 Nov; 159():105507. PubMed ID: 34509608
[TBL] [Abstract][Full Text] [Related]
20. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.
Mazzulli JR; Xu YH; Sun Y; Knight AL; McLean PJ; Caldwell GA; Sidransky E; Grabowski GA; Krainc D
Cell; 2011 Jul; 146(1):37-52. PubMed ID: 21700325
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]