These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

209 related articles for article (PubMed ID: 26161543)

  • 21. "Negative" Impact: The Role of Payload Charge in the Physicochemical Stability of Auristatin Antibody-Drug Conjugates.
    Johann F; Wöll S; Gieseler H
    J Pharm Sci; 2024 Aug; 113(8):2433-2442. PubMed ID: 38679233
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody-drug Conjugate (ARX788) for Breast Cancer Treatment.
    Nagaraja Shastri P; Zhu J; Skidmore L; Liang X; Ji Y; Gu Y; Tian F; Yao S; Xia G
    Mol Cancer Ther; 2020 Sep; 19(9):1822-1832. PubMed ID: 32499302
    [TBL] [Abstract][Full Text] [Related]  

  • 23. A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.
    Dong L; Li C; Locuson C; Chen S; Qian MG
    Anal Chem; 2018 May; 90(10):5989-5994. PubMed ID: 29688004
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry.
    McCombs JR; Owen SC
    AAPS J; 2015 Mar; 17(2):339-51. PubMed ID: 25604608
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency.
    Anami Y; Xiong W; Gui X; Deng M; Zhang CC; Zhang N; An Z; Tsuchikama K
    Org Biomol Chem; 2017 Jul; 15(26):5635-5642. PubMed ID: 28649690
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Development and validation of bioanalytical assays for the quantification of 9MW2821, a nectin-4-targeting antibody-drug conjugate.
    Fang P; You M; Cao Y; Feng Q; Shi L; Wang J; Sun X; Yu D; Zhou W; Yin L; Mei F; Zhu X; Cheng A; Tan X
    J Pharm Biomed Anal; 2024 Sep; 248():116318. PubMed ID: 38908237
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates.
    Chuprakov S; Ogunkoya AO; Barfield RM; Bauzon M; Hickle C; Kim YC; Yeo D; Zhang F; Rabuka D; Drake PM
    Bioconjug Chem; 2021 Apr; 32(4):746-754. PubMed ID: 33689309
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound.
    Pes L; Koester SD; Magnusson JP; Chercheja S; Medda F; Abu Ajaj K; Rognan D; Daum S; Nollmann FI; Garcia Fernandez J; Perez Galan P; Walter HK; Warnecke A; Kratz F
    J Control Release; 2019 Feb; 296():81-92. PubMed ID: 30639692
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
    Dorywalska M; Dushin R; Moine L; Farias SE; Zhou D; Navaratnam T; Lui V; Hasa-Moreno A; Casas MG; Tran TT; Delaria K; Liu SH; Foletti D; O'Donnell CJ; Pons J; Shelton DL; Rajpal A; Strop P
    Mol Cancer Ther; 2016 May; 15(5):958-70. PubMed ID: 26944918
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.
    Junutula JR; Flagella KM; Graham RA; Parsons KL; Ha E; Raab H; Bhakta S; Nguyen T; Dugger DL; Li G; Mai E; Lewis Phillips GD; Hiraragi H; Fuji RN; Tibbitts J; Vandlen R; Spencer SD; Scheller RH; Polakis P; Sliwkowski MX
    Clin Cancer Res; 2010 Oct; 16(19):4769-78. PubMed ID: 20805300
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A new delivery system for auristatin in STxB-drug conjugate therapy.
    Batisse C; Dransart E; Ait Sarkouh R; Brulle L; Bai SK; Godefroy S; Johannes L; Schmidt F
    Eur J Med Chem; 2015 May; 95():483-91. PubMed ID: 25847766
    [TBL] [Abstract][Full Text] [Related]  

  • 32. A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species.
    Excoffier M; Janin-Bussat MC; Beau-Larvor C; Troncy L; Corvaia N; Beck A; Klinguer-Hamour C
    J Chromatogr B Analyt Technol Biomed Life Sci; 2016 Oct; 1032():149-154. PubMed ID: 27267073
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Phosphopantetheinyl Transferases.
    Grünewald J; Klock HE; Cellitti SE; Bursulaya B; McMullan D; Jones DH; Chiu HP; Wang X; Patterson P; Zhou H; Vance J; Nigoghossian E; Tong H; Daniel D; Mallet W; Ou W; Uno T; Brock A; Lesley SA; Geierstanger BH
    Bioconjug Chem; 2015 Dec; 26(12):2554-62. PubMed ID: 26588668
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety.
    Wang Y; Liu L; Fan S; Xiao D; Xie F; Li W; Zhong W; Zhou X
    Cancers (Basel); 2020 Mar; 12(3):. PubMed ID: 32245171
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
    Su D; Kozak KR; Sadowsky J; Yu SF; Fourie-O'Donohue A; Nelson C; Vandlen R; Ohri R; Liu L; Ng C; He J; Davis H; Lau J; Del Rosario G; Cosino E; Cruz-Chuh JD; Ma Y; Zhang D; Darwish M; Cai W; Chen C; Zhou H; Lu J; Liu Y; Kaur S; Xu K; Pillow TH
    Bioconjug Chem; 2018 Apr; 29(4):1155-1167. PubMed ID: 29481745
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
    Rago B; Tumey LN; Wei C; Barletta F; Clark T; Hansel S; Han X
    Bioconjug Chem; 2017 Feb; 28(2):620-626. PubMed ID: 28140559
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs.
    Rades N; Achazi K; Qiu M; Deng C; Haag R; Zhong Z; Licha K
    J Control Release; 2019 Apr; 300():13-21. PubMed ID: 30794827
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys.
    Lu D; Jin JY; Girish S; Agarwal P; Li D; Prabhu S; Dere RC; Saad OM; Nazzal D; Koppada N; Ramanujan S; Ng CM
    Pharm Res; 2015 Jun; 32(6):1907-19. PubMed ID: 25467958
    [TBL] [Abstract][Full Text] [Related]  

  • 39. First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs).
    Merkul E; Sijbrandi NJ; Muns JA; Aydin I; Adamzek K; Houthoff HJ; Nijmeijer B; Van Dongen GAMS
    Expert Opin Drug Deliv; 2019 Aug; 16(8):783-793. PubMed ID: 31327255
    [No Abstract]   [Full Text] [Related]  

  • 40. Sulfatase-cleavable linkers for antibody-drug conjugates.
    Bargh JD; Walsh SJ; Isidro-Llobet A; Omarjee S; Carroll JS; Spring DR
    Chem Sci; 2020 Jan; 11(9):2375-2380. PubMed ID: 34084399
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.