193 related articles for article (PubMed ID: 26181715)
1. Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.
Cioffi CL; Racz B; Freeman EE; Conlon MP; Chen P; Stafford DG; Schwarz DM; Zhu L; Kitchen DB; Barnes KD; Dobri N; Michelotti E; Cywin CL; Martin WH; Pearson PG; Johnson G; Petrukhin K
J Med Chem; 2015 Aug; 58(15):5863-88. PubMed ID: 26181715
[TBL] [Abstract][Full Text] [Related]
2. Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.
Cioffi CL; Muthuraman P; Raja A; Varadi A; Racz B; Petrukhin K
J Med Chem; 2020 Oct; 63(19):11054-11084. PubMed ID: 32878437
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
Cioffi CL; Dobri N; Freeman EE; Conlon MP; Chen P; Stafford DG; Schwarz DM; Golden KC; Zhu L; Kitchen DB; Barnes KD; Racz B; Qin Q; Michelotti E; Cywin CL; Martin WH; Pearson PG; Johnson G; Petrukhin K
J Med Chem; 2014 Sep; 57(18):7731-57. PubMed ID: 25210858
[TBL] [Abstract][Full Text] [Related]
4. A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
Racz B; Varadi A; Kong J; Allikmets R; Pearson PG; Johnson G; Cioffi CL; Petrukhin K
J Biol Chem; 2018 Jul; 293(29):11574-11588. PubMed ID: 29871924
[TBL] [Abstract][Full Text] [Related]
5. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.
Dobri N; Qin Q; Kong J; Yamamoto K; Liu Z; Moiseyev G; Ma JX; Allikmets R; Sparrow JR; Petrukhin K
Invest Ophthalmol Vis Sci; 2013 Jan; 54(1):85-95. PubMed ID: 23211825
[TBL] [Abstract][Full Text] [Related]
6. Baseline Levels of Retinol-Binding Protein 4 and Vitamin A in Healthy Subjects, Stargardt Disease, and Geographic Atrophy Patients.
Janeschitz-Kriegl L; Cattaneo M; Scholl HPN
Ophthalmic Res; 2022; 65(3):351-360. PubMed ID: 35108705
[TBL] [Abstract][Full Text] [Related]
7. Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Cioffi CL; Racz B; Varadi A; Freeman EE; Conlon MP; Chen P; Zhu L; Kitchen DB; Barnes KD; Martin WH; Pearson PG; Johnson G; Blaner WS; Petrukhin K
J Med Chem; 2019 Jun; 62(11):5470-5500. PubMed ID: 31079449
[TBL] [Abstract][Full Text] [Related]
8. Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development.
Kim N; Priefer R
Eur J Med Chem; 2021 Dec; 226():113856. PubMed ID: 34547506
[TBL] [Abstract][Full Text] [Related]
9. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.
Nakamura S; Kamaura M; Akao Y; Nakamura N; Mizukami A; Goto A; Furuyama N; Cho N; Kasai S
Bioorg Med Chem; 2022 Jan; 54():116553. PubMed ID: 34953340
[TBL] [Abstract][Full Text] [Related]
10. Stem Cell-Based Therapy for Diseases of the Retinal Pigment Epithelium: From Bench to Bedside.
Sachdeva MM; Eliott D
Semin Ophthalmol; 2016; 31(1-2):25-9. PubMed ID: 26959126
[TBL] [Abstract][Full Text] [Related]
11. Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.
Racz B; Varadi A; Pearson PG; Petrukhin K
PLoS One; 2020; 15(1):e0228291. PubMed ID: 31978148
[TBL] [Abstract][Full Text] [Related]
12. Fluorescence Lifetime Patterns of Retinal Pigment Epithelium Atrophy in Patients with Stargardt Disease and Age-Related Macular Degeneration.
Solberg Y; Dysli C; Escher P; Berger L; Wolf S; Zinkernagel MS
Ophthalmologica; 2020; 243(3):195-206. PubMed ID: 31743906
[TBL] [Abstract][Full Text] [Related]
13. Stargardt macular dystrophy and evolving therapies.
Hussain RM; Ciulla TA; Berrocal AM; Gregori NZ; Flynn HW; Lam BL
Expert Opin Biol Ther; 2018 Oct; 18(10):1049-1059. PubMed ID: 30129371
[TBL] [Abstract][Full Text] [Related]
14. Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.
Cioffi CL; Raja A; Muthuraman P; Jayaraman A; Jayakumar S; Varadi A; Racz B; Petrukhin K
J Med Chem; 2021 Jul; 64(13):9010-9041. PubMed ID: 34138572
[TBL] [Abstract][Full Text] [Related]
15. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Wang Y; Connors R; Fan P; Wang X; Wang Z; Liu J; Kayser F; Medina JC; Johnstone S; Xu H; Thibault S; Walker N; Conn M; Zhang Y; Liu Q; Grillo MP; Motani A; Coward P; Wang Z
Bioorg Med Chem Lett; 2014 Jul; 24(13):2885-91. PubMed ID: 24835984
[TBL] [Abstract][Full Text] [Related]
16. Treatment of Stargardt disease with dobesilate.
Cuevas P; Outeiriño LA; Angulo J; Giménez-Gallego G
BMJ Case Rep; 2012 Oct; 2012():. PubMed ID: 23076703
[TBL] [Abstract][Full Text] [Related]
17. Differential Disease Progression in Atrophic Age-Related Macular Degeneration and Late-Onset Stargardt Disease.
Lindner M; Lambertus S; Mauschitz MM; Bax NM; Kersten E; Lüning A; Nadal J; Schmitz-Valckenberg S; Schmid M; Holz FG; Hoyng CB; Fleckenstein M;
Invest Ophthalmol Vis Sci; 2017 Feb; 58(2):1001-1007. PubMed ID: 28288486
[TBL] [Abstract][Full Text] [Related]
18. Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration.
Mata NL; Lichter JB; Vogel R; Han Y; Bui TV; Singerman LJ
Retina; 2013 Mar; 33(3):498-507. PubMed ID: 23023528
[TBL] [Abstract][Full Text] [Related]
19. Treatment for atrophic macular degeneration.
Meleth AD; Wong WT; Chew EY
Curr Opin Ophthalmol; 2011 May; 22(3):190-3. PubMed ID: 21427574
[TBL] [Abstract][Full Text] [Related]
20. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography.
Ahlers C; Götzinger E; Pircher M; Golbaz I; Prager F; Schütze C; Baumann B; Hitzenberger CK; Schmidt-Erfurth U
Invest Ophthalmol Vis Sci; 2010 Apr; 51(4):2149-57. PubMed ID: 19797228
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]