161 related articles for article (PubMed ID: 26202434)
21. Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights.
Poulin P; Haddad S
J Pharm Sci; 2018 Jul; 107(7):1791-1797. PubMed ID: 29567347
[TBL] [Abstract][Full Text] [Related]
22. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.
Abe K; Bridges AS; Yue W; Brouwer KL
J Pharmacol Exp Ther; 2008 Sep; 326(3):983-90. PubMed ID: 18574002
[TBL] [Abstract][Full Text] [Related]
23. In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction.
Bowman CM; Benet LZ
J Pharm Sci; 2019 Jul; 108(7):2500-2504. PubMed ID: 30817922
[TBL] [Abstract][Full Text] [Related]
24. Metabolic characterization of a tripeptide human immunodeficiency virus type 1 protease inhibitor, KNI-272, in rat liver microsomes.
Kiriyama A; Nishiura T; Yamaji H; Takada K
Antimicrob Agents Chemother; 1999 Mar; 43(3):549-56. PubMed ID: 10049266
[TBL] [Abstract][Full Text] [Related]
25. Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Huang L; Chen A; Roberts J; Janosky B; Be X; Berry L; Lin MH
Xenobiotica; 2012 Sep; 42(9):830-40. PubMed ID: 22439758
[TBL] [Abstract][Full Text] [Related]
26. Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes.
Li N; Badrinarayanan A; Li X; Roberts J; Hayashi M; Virk M; Gupta A
Drug Metab Dispos; 2020 Oct; 48(10):861-872. PubMed ID: 32759366
[TBL] [Abstract][Full Text] [Related]
27. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
Kuperman AV; Kalgutkar AS; Marfat A; Chambers RJ; Liston TE
Drug Metab Dispos; 2001 Nov; 29(11):1403-9. PubMed ID: 11602515
[TBL] [Abstract][Full Text] [Related]
28. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.
Shibata Y; Takahashi H; Ishii Y
Drug Metab Dispos; 2000 Dec; 28(12):1518-23. PubMed ID: 11095592
[TBL] [Abstract][Full Text] [Related]
29. Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.
Naritomi Y; Terashita S; Kagayama A; Sugiyama Y
Drug Metab Dispos; 2003 May; 31(5):580-8. PubMed ID: 12695346
[TBL] [Abstract][Full Text] [Related]
30. Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.
Hutzler JM; Ring BJ; Anderson SR
Drug Metab Dispos; 2015 Dec; 43(12):1917-28. PubMed ID: 26363026
[TBL] [Abstract][Full Text] [Related]
31. Prediction of total hepatic clearance by combining metabolism, transport, and permeability data in the in vitro-in vivo extrapolation methods: emphasis on an apparent fraction unbound in liver for drugs.
Poulin P
J Pharm Sci; 2013 Jul; 102(7):2085-95. PubMed ID: 23613473
[TBL] [Abstract][Full Text] [Related]
32. Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.
Ito K; Houston JB
Pharm Res; 2004 May; 21(5):785-92. PubMed ID: 15180335
[TBL] [Abstract][Full Text] [Related]
33. Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.
Poirier A; Cascais AC; Funk C; Lavé T
Chem Biodivers; 2009 Nov; 6(11):1975-87. PubMed ID: 19937834
[TBL] [Abstract][Full Text] [Related]
34. Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats.
Yoon I; Han S; Choi YH; Kang HE; Cho HJ; Kim JS; Shim CK; Chung SJ; Chong S; Kim DD
Xenobiotica; 2012 Nov; 42(11):1110-9. PubMed ID: 22747239
[TBL] [Abstract][Full Text] [Related]
35. Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
Jones HM; Hallifax D; Houston JB
Drug Metab Dispos; 2004 May; 32(5):572-80. PubMed ID: 15100181
[TBL] [Abstract][Full Text] [Related]
36. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.
Lam JL; Okochi H; Huang Y; Benet LZ
Drug Metab Dispos; 2006 Aug; 34(8):1336-44. PubMed ID: 16698890
[TBL] [Abstract][Full Text] [Related]
37. Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.
Poirier A; Funk C; Scherrmann JM; Lavé T
Mol Pharm; 2009; 6(6):1716-33. PubMed ID: 19739673
[TBL] [Abstract][Full Text] [Related]
38. Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.
Carlile DJ; Zomorodi K; Houston JB
Drug Metab Dispos; 1997 Aug; 25(8):903-11. PubMed ID: 9280396
[TBL] [Abstract][Full Text] [Related]
39. The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human.
Somers GI; Bayliss MK; Houston JB
Xenobiotica; 2007 Aug; 37(8):855-69. PubMed ID: 17701833
[TBL] [Abstract][Full Text] [Related]
40. Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes.
Ye ZW; Van Pelt J; Camus S; Snoeys J; Augustijns P; Annaert P
J Pharm Sci; 2010 Jun; 99(6):2886-98. PubMed ID: 20014428
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
