139 related articles for article (PubMed ID: 26220948)
1. Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel.
Liu C; Chen Z; Zhong K; Li L; Zhu W; Chen X; Zhong D
Drug Metab Dispos; 2015 Oct; 43(10):1632-41. PubMed ID: 26220948
[TBL] [Abstract][Full Text] [Related]
2. Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.
Kim MJ; Jeong ES; Park JS; Lee SJ; Ghim JL; Choi CS; Shin JG; Kim DH
Drug Metab Dispos; 2014 Jan; 42(1):141-52. PubMed ID: 24170778
[TBL] [Abstract][Full Text] [Related]
3. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Kazui M; Nishiya Y; Ishizuka T; Hagihara K; Farid NA; Okazaki O; Ikeda T; Kurihara A
Drug Metab Dispos; 2010 Jan; 38(1):92-9. PubMed ID: 19812348
[TBL] [Abstract][Full Text] [Related]
4. Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.
Dansette PM; Rosi J; Bertho G; Mansuy D
Chem Res Toxicol; 2012 Feb; 25(2):348-56. PubMed ID: 22103858
[TBL] [Abstract][Full Text] [Related]
5. A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.
Hagihara K; Kazui M; Kurihara A; Yoshiike M; Honda K; Okazaki O; Farid NA; Ikeda T
Drug Metab Dispos; 2009 Nov; 37(11):2145-52. PubMed ID: 19704027
[TBL] [Abstract][Full Text] [Related]
6. Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel.
Kazui M; Hagihara K; Izumi T; Ikeda T; Kurihara A
Drug Metab Dispos; 2014 Jul; 42(7):1138-45. PubMed ID: 24733788
[TBL] [Abstract][Full Text] [Related]
7. Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma.
Liu C; Lu Y; Sun H; Yang J; Liu Y; Lai X; Gong Y; Liu X; Li Y; Zhang Y; Chen X; Zhong D
J Pharm Biomed Anal; 2018 Feb; 149():394-402. PubMed ID: 29154109
[TBL] [Abstract][Full Text] [Related]
8. In Vitro Assessment of Potential for CYP-Inhibition-Based Drug-Drug Interaction Between Vonoprazan and Clopidogrel.
Nishihara M; Yamasaki H; Czerniak R; Jenkins H
Eur J Drug Metab Pharmacokinet; 2019 Apr; 44(2):217-227. PubMed ID: 30361928
[TBL] [Abstract][Full Text] [Related]
9. CYP-independent inhibition of platelet aggregation in rabbits by a mixed disulfide conjugate of clopidogrel.
Zhang H; Lauver DA; Hollenberg PF
Thromb Haemost; 2014 Dec; 112(6):1304-11. PubMed ID: 25230737
[TBL] [Abstract][Full Text] [Related]
10. Differential inhibitory effects of proton pump inhibitors on the metabolism and antiplatelet activities of clopidogrel and prasugrel.
Chen CH; Yang JC; Uang YS; Lin CJ
Biopharm Drug Dispos; 2012 Jul; 33(5):278-83. PubMed ID: 22623337
[TBL] [Abstract][Full Text] [Related]
11. Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.
Nishiya Y; Hagihara K; Kurihara A; Okudaira N; Farid NA; Okazaki O; Ikeda T
Xenobiotica; 2009 Nov; 39(11):836-43. PubMed ID: 19845434
[TBL] [Abstract][Full Text] [Related]
12. Stereoselective metabolism of lansoprazole by human liver cytochrome P450 enzymes.
Kim KA; Kim MJ; Park JY; Shon JH; Yoon YR; Lee SS; Liu KH; Chun JH; Hyun MH; Shin JG
Drug Metab Dispos; 2003 Oct; 31(10):1227-34. PubMed ID: 12975331
[TBL] [Abstract][Full Text] [Related]
13. Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro.
Abell LM; Liu EC
J Pharmacol Exp Ther; 2011 Nov; 339(2):589-96. PubMed ID: 21828263
[TBL] [Abstract][Full Text] [Related]
14. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.
Hagihara K; Kazui M; Ikenaga H; Nanba T; Fusegawa K; Takahashi M; Kurihara A; Okazaki O; Farid NA; Ikeda T
Xenobiotica; 2009 Mar; 39(3):218-26. PubMed ID: 19280520
[TBL] [Abstract][Full Text] [Related]
15. Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.
Richter T; Mürdter TE; Heinkele G; Pleiss J; Tatzel S; Schwab M; Eichelbaum M; Zanger UM
J Pharmacol Exp Ther; 2004 Jan; 308(1):189-97. PubMed ID: 14563790
[TBL] [Abstract][Full Text] [Related]
16. Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.
Dansette PM; Levent D; Hessani A; Bertho G; Mansuy D
Chem Res Toxicol; 2013 May; 26(5):794-802. PubMed ID: 23527615
[TBL] [Abstract][Full Text] [Related]
17. The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro.
Ancrenaz V; Desmeules J; James R; Fontana P; Reny JL; Dayer P; Daali Y
Br J Pharmacol; 2012 Aug; 166(8):2362-70. PubMed ID: 22428615
[TBL] [Abstract][Full Text] [Related]
18. Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel.
Zhang H; Lauver DA; Lucchesi BR; Hollenberg PF
Mol Pharmacol; 2013 Apr; 83(4):848-56. PubMed ID: 23348501
[TBL] [Abstract][Full Text] [Related]
19. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6.
Walsky RL; Obach RS
Drug Metab Dispos; 2007 Nov; 35(11):2053-9. PubMed ID: 17682072
[TBL] [Abstract][Full Text] [Related]
20. Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate.
Hagihara K; Kazui M; Kurihara A; Ikeda T; Izumi T
Drug Metab Dispos; 2012 Sep; 40(9):1854-9. PubMed ID: 22733806
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
