BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

318 related articles for article (PubMed ID: 26222440)

  • 1. Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function.
    Grover P; Shi H; Baumgartner M; Camacho CJ; Smithgall TE
    PLoS One; 2015; 10(7):e0133590. PubMed ID: 26222440
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck.
    Dorman HR; Close D; Wingert BM; Camacho CJ; Johnston PA; Smithgall TE
    Front Chem; 2019; 7():822. PubMed ID: 31850311
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap.
    Corbi-Verge C; Marinelli F; Zafra-Ruano A; Ruiz-Sanz J; Luque I; Faraldo-Gómez JD
    Proc Natl Acad Sci U S A; 2013 Sep; 110(36):E3372-80. PubMed ID: 23959873
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.
    Chen S; Brier S; Smithgall TE; Engen JR
    Protein Sci; 2007 Apr; 16(4):572-81. PubMed ID: 17327393
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Abl N-terminal cap stabilization of SH3 domain dynamics.
    Chen S; Dumitrescu TP; Smithgall TE; Engen JR
    Biochemistry; 2008 May; 47(21):5795-803. PubMed ID: 18452309
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An intramolecular SH3-domain interaction regulates c-Abl activity.
    Barilá D; Superti-Furga G
    Nat Genet; 1998 Mar; 18(3):280-2. PubMed ID: 9500553
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
    Chen S; O'Reilly LP; Smithgall TE; Engen JR
    J Mol Biol; 2008 Nov; 383(2):414-23. PubMed ID: 18775435
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes.
    Lynch BA; Minor C; Loiacono KA; van Schravendijk MR; Ram MK; Sundaramoorthi R; Adams SE; Phillips T; Holt D; Rickles RJ; MacNeil IA
    Anal Biochem; 1999 Nov; 275(1):62-73. PubMed ID: 10542110
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain.
    Brasher BB; Roumiantsev S; Van Etten RA
    Oncogene; 2001 Nov; 20(53):7744-52. PubMed ID: 11753652
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular Dynamics Simulations and Structural Network Analysis of c-Abl and c-Src Kinase Core Proteins: Capturing Allosteric Mechanisms and Communication Pathways from Residue Centrality.
    Tse A; Verkhivker GM
    J Chem Inf Model; 2015 Aug; 55(8):1645-62. PubMed ID: 26236953
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
    Panjarian S; Iacob RE; Chen S; Wales TE; Engen JR; Smithgall TE
    J Biol Chem; 2013 Mar; 288(9):6116-29. PubMed ID: 23303187
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.
    Mayer BJ; Baltimore D
    Mol Cell Biol; 1994 May; 14(5):2883-94. PubMed ID: 8164650
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism.
    Alvarado JJ; Betts L; Moroco JA; Smithgall TE; Yeh JI
    J Biol Chem; 2010 Nov; 285(46):35455-61. PubMed ID: 20810664
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Atomistic Modeling of the ABL Kinase Regulation by Allosteric Modulators Using Structural Perturbation Analysis and Community-Based Network Reconstruction of Allosteric Communications.
    Astl L; Verkhivker GM
    J Chem Theory Comput; 2019 May; 15(5):3362-3380. PubMed ID: 31017783
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.
    Pisabarro MT; Serrano L; Wilmanns M
    J Mol Biol; 1998 Aug; 281(3):513-21. PubMed ID: 9698566
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.
    Nam HJ; Haser WG; Roberts TM; Frederick CA
    Structure; 1996 Sep; 4(9):1105-14. PubMed ID: 8805596
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase.
    Glover RT; Angiolieri M; Kelly S; Monaghan DT; Wang JY; Smithgall TE; Buller AL
    J Biol Chem; 2000 Apr; 275(17):12725-9. PubMed ID: 10777567
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
    Zvara A; Fajardo JE; Escalante M; Cotton G; Muir T; Kirsch KH; Birge RB
    Oncogene; 2001 Feb; 20(8):951-61. PubMed ID: 11314030
    [TBL] [Abstract][Full Text] [Related]  

  • 19. c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.
    Badger J; Grover P; Shi H; Panjarian SB; Engen JR; Smithgall TE; Makowski L
    Biochemistry; 2016 Jun; 55(23):3251-60. PubMed ID: 27166638
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
    Nagar B; Hantschel O; Seeliger M; Davies JM; Weis WI; Superti-Furga G; Kuriyan J
    Mol Cell; 2006 Mar; 21(6):787-98. PubMed ID: 16543148
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.