These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

106 related articles for article (PubMed ID: 26230757)

  • 1. Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide-tubulin pharmacophore.
    Churchill CD; Klobukowski M; Tuszynski JA
    J Biomol Struct Dyn; 2016 Jul; 34(7):1455-69. PubMed ID: 26230757
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.
    Churchill CD; Klobukowski M; Tuszynski JA
    Chem Biol Drug Des; 2015 Aug; 86(2):190-9. PubMed ID: 25376845
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
    Bennett MJ; Barakat K; Huzil JT; Tuszynski J; Schriemer DC
    Chem Biol; 2010 Jul; 17(7):725-34. PubMed ID: 20659685
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
    Zúñiga MA; Alderete JB; Jaña GA; Jiménez VA
    J Comput Aided Mol Des; 2017 Jul; 31(7):643-652. PubMed ID: 28597356
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
    Pryor DE; O'Brate A; Bilcer G; Díaz JF; Wang Y; Wang Y; Kabaki M; Jung MK; Andreu JM; Ghosh AK; Giannakakou P; Hamel E
    Biochemistry; 2002 Jul; 41(29):9109-15. PubMed ID: 12119025
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis of microtubule stabilization by laulimalide and peloruside A.
    Prota AE; Bargsten K; Northcote PT; Marsh M; Altmann KH; Miller JH; Díaz JF; Steinmetz MO
    Angew Chem Int Ed Engl; 2014 Feb; 53(6):1621-5. PubMed ID: 24470331
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural investigations into the binding mode of novel neolignans Cmp10 and Cmp19 microtubule stabilizers by in silico molecular docking, molecular dynamics, and binding free energy calculations.
    Tripathi S; Kumar A; Kumar BS; Negi AS; Sharma A
    J Biomol Struct Dyn; 2016 Jun; 34(6):1232-40. PubMed ID: 26212016
    [TBL] [Abstract][Full Text] [Related]  

  • 8. βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.
    Kanakkanthara A; Rowe MR; Field JJ; Northcote PT; Teesdale-Spittle PH; Miller JH
    Cancer Lett; 2015 Sep; 365(2):251-60. PubMed ID: 26052091
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modulation of lateral and longitudinal interdimeric interactions in microtubule models by Laulimalide and Peloruside A association: A molecular modeling approach on the mechanism of microtubule stabilizing agents.
    Zúñiga MA; Alderete JB; Jaña GA; Fernandez PA; Ramos MJ; Jiménez VA
    Chem Biol Drug Des; 2018 May; 91(5):1042-1055. PubMed ID: 29316292
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
    Khrapunovich-Baine M; Menon V; Yang CP; Northcote PT; Miller JH; Angeletti RH; Fiser A; Horwitz SB; Xiao H
    J Biol Chem; 2011 Apr; 286(13):11765-78. PubMed ID: 21245138
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.
    Pera B; Razzak M; Trigili C; Pineda O; Canales A; Buey RM; Jiménez-Barbero J; Northcote PT; Paterson I; Barasoain I; Díaz JF
    Chembiochem; 2010 Aug; 11(12):1669-78. PubMed ID: 20665616
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.
    Mooberry SL; Tien G; Hernandez AH; Plubrukarn A; Davidson BS
    Cancer Res; 1999 Feb; 59(3):653-60. PubMed ID: 9973214
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Wangzaozin A, a potent novel microtubule stabilizer, targets both the taxane and laulimalide sites on β-tubulin through molecular dynamics simulations.
    Yang MH; Mao J; Zhu JH; Zhang H; Ding L
    Life Sci; 2022 Jul; 301():120583. PubMed ID: 35504334
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.
    Gapud EJ; Bai R; Ghosh AK; Hamel E
    Mol Pharmacol; 2004 Jul; 66(1):113-21. PubMed ID: 15213302
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.
    Kanakkanthara A; Wilmes A; O'Brate A; Escuin D; Chan A; Gjyrezi A; Crawford J; Rawson P; Kivell B; Northcote PT; Hamel E; Giannakakou P; Miller JH
    Mol Cancer Ther; 2011 Aug; 10(8):1419-29. PubMed ID: 21653684
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.
    Hamel E; Day BW; Miller JH; Jung MK; Northcote PT; Ghosh AK; Curran DP; Cushman M; Nicolaou KC; Paterson I; Sorensen EJ
    Mol Pharmacol; 2006 Nov; 70(5):1555-64. PubMed ID: 16887932
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.
    Clark EA; Hills PM; Davidson BS; Wender PA; Mooberry SL
    Mol Pharm; 2006; 3(4):457-67. PubMed ID: 16889440
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stabilization of microtubules by taxane diterpenoids: insight from docking and MD simulations.
    Yadava U; Gupta H; Roychoudhury M
    J Biol Phys; 2015 Mar; 41(2):117-33. PubMed ID: 25542396
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Microtubule-stabilizing agents based on designed laulimalide analogues.
    Mooberry SL; Randall-Hlubek DA; Leal RM; Hegde SG; Hubbard RD; Zhang L; Wender PA
    Proc Natl Acad Sci U S A; 2004 Jun; 101(23):8803-8. PubMed ID: 15161976
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Unravelling the covalent binding of zampanolide and taccalonolide AJ to a minimalist representation of a human microtubule.
    Sánchez-Murcia PA; Mills A; Cortés-Cabrera Á; Gago F
    J Comput Aided Mol Des; 2019 Jul; 33(7):627-644. PubMed ID: 31152293
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.