These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

114 related articles for article (PubMed ID: 26234198)

  • 1. An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.
    Palermo G; Minniti E; Greco ML; Riccardi L; Simoni E; Convertino M; Marchetti C; Rosini M; Sissi C; Minarini A; De Vivo M
    Chem Commun (Camb); 2015 Oct; 51(76):14310-3. PubMed ID: 26234198
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
    Gentry AC; Pitts SL; Jablonsky MJ; Bailly C; Graves DE; Osheroff N
    Biochemistry; 2011 Apr; 50(15):3240-9. PubMed ID: 21413765
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II.
    Chelouah S; Monod-Wissler C; Bailly C; Barret JM; Guilbaud N; Vispé S; Käs E
    PLoS One; 2011; 6(8):e23597. PubMed ID: 21853156
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II.
    Brel V; Annereau JP; Vispé S; Kruczynski A; Bailly C; Guilbaud N
    Biochem Pharmacol; 2011 Dec; 82(12):1843-52. PubMed ID: 21924246
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.
    Ballot C; Jendoubi M; Kluza J; Jonneaux A; Laine W; Formstecher P; Bailly C; Marchetti P
    Apoptosis; 2012 Apr; 17(4):364-76. PubMed ID: 22127645
    [TBL] [Abstract][Full Text] [Related]  

  • 6. F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
    Barret JM; Kruczynski A; Vispé S; Annereau JP; Brel V; Guminski Y; Delcros JG; Lansiaux A; Guilbaud N; Imbert T; Bailly C
    Cancer Res; 2008 Dec; 68(23):9845-53. PubMed ID: 19047165
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy.
    Bailly C
    Chem Rev; 2012 Jul; 112(7):3611-40. PubMed ID: 22397403
    [No Abstract]   [Full Text] [Related]  

  • 8. The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks.
    Bombarde O; Larminat F; Gomez D; Frit P; Racca C; Gomes B; Guilbaud N; Calsou P
    Mol Cancer Ther; 2017 Oct; 16(10):2166-2177. PubMed ID: 28611105
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
    Ortega JA; Riccardi L; Minniti E; Borgogno M; Arencibia JM; Greco ML; Minarini A; Sissi C; De Vivo M
    J Med Chem; 2018 Feb; 61(3):1375-1379. PubMed ID: 29077404
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
    Drwal MN; Marinello J; Manzo SG; Wakelin LP; Capranico G; Griffith R
    PLoS One; 2014; 9(12):e114904. PubMed ID: 25489853
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.
    Sun LY; Zhu LW; Tang YJ
    Sci Rep; 2018 Oct; 8(1):14949. PubMed ID: 30297860
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors.
    Bkhaitan MM; Mirza AZ; Shamshad H; Ali HI
    J Mol Graph Model; 2017 May; 73():74-93. PubMed ID: 28242581
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
    Leblond P; Boulet E; Bal-Mahieu C; Pillon A; Kruczynski A; Guilbaud N; Bailly C; Sarrazin T; Lartigau E; Lansiaux A; Meignan S
    Invest New Drugs; 2014 Oct; 32(5):883-92. PubMed ID: 25008900
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma.
    Tierny D; Serres F; Segaoula Z; Bemelmans I; Bouchaert E; Pétain A; Brel V; Couffin S; Marchal T; Nguyen L; Thuru X; Ferré P; Guilbaud N; Gomes B
    Clin Cancer Res; 2015 Dec; 21(23):5314-23. PubMed ID: 26169968
    [TBL] [Abstract][Full Text] [Related]  

  • 15. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
    Shankaraiah N; Kumar NP; Amula SB; Nekkanti S; Jeengar MK; Naidu VG; Reddy TS; Kamal A
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4239-44. PubMed ID: 26292628
    [TBL] [Abstract][Full Text] [Related]  

  • 16. F14512, a polyamine-vectorized inhibitor of topoisomerase II, exhibits a marked anti-tumor activity in ovarian cancer.
    Thibault B; Clement E; Zorza G; Meignan S; Delord JP; Couderc B; Bailly C; Narducci F; Vandenberghe I; Kruczynski A; Guilbaud N; Ferré P; Annereau JP
    Cancer Lett; 2016 Jan; 370(1):10-8. PubMed ID: 26404751
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles.
    Plech T; Kaproń B; Paneth A; Wujec M; Czarnomysy R; Bielawska A; Bielawski K; Trotsko N; Kuśmierz E; Paneth P
    J Enzyme Inhib Med Chem; 2015 Dec; 30(6):1021-6. PubMed ID: 25792499
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.
    Rothenborg-Jensen L; Hansen HF; Wessel I; Nitiss JL; Schmidt G; Jensen PB; Sehested M; Jensen LH
    Anticancer Drug Des; 2001 Dec; 16(6):305-15. PubMed ID: 12375883
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors.
    Zhao Y; Ge CW; Wu ZH; Wang CN; Fang JH; Zhu L
    Eur J Med Chem; 2011 Mar; 46(3):901-6. PubMed ID: 21277655
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.
    Zhang X; Bao B; Yu X; Tong L; Luo Y; Huang Q; Su M; Sheng L; Li J; Zhu H; Yang B; Zhang X; Chen Y; Lu W
    Bioorg Med Chem; 2013 Nov; 21(22):6981-95. PubMed ID: 24095018
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.