BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 26242248)

  • 1. Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity.
    Jefferson T; McShan D; Warfield J; Ogungbe IV
    Chem Biol Drug Des; 2016 Jan; 87(1):154-8. PubMed ID: 26242248
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
    Mallari JP; Shelat A; Kosinski A; Caffrey CR; Connelly M; Zhu F; McKerrow JH; Guy RK
    Bioorg Med Chem Lett; 2008 May; 18(9):2883-5. PubMed ID: 18420405
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improved trypanocidal activities of cathepsin L inhibitors.
    Nkemgu NJ; Grande R; Hansell E; McKerrow JH; Caffrey CR; Steverding D
    Int J Antimicrob Agents; 2003 Aug; 22(2):155-9. PubMed ID: 12927956
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
    Giroud M; Dietzel U; Anselm L; Banner D; Kuglstatter A; Benz J; Blanc JB; Gaufreteau D; Liu H; Lin X; Stich A; Kuhn B; Schuler F; Kaiser M; Brun R; Schirmeister T; Kisker C; Diederich F; Haap W
    J Med Chem; 2018 Apr; 61(8):3350-3369. PubMed ID: 29590750
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
    Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
    Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Screening North American plant extracts in vitro against Trypanosoma brucei for discovery of new antitrypanosomal drug leads.
    Jain S; Jacob M; Walker L; Tekwani B
    BMC Complement Altern Med; 2016 May; 16():131. PubMed ID: 27193901
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bistacrines as potential antitrypanosomal agents.
    Schmidt I; Göllner S; Fuß A; Stich A; Kucharski A; Schirmeister T; Katzowitsch E; Bruhn H; Miliu A; Krauth-Siegel RL; Holzgrabe U
    Bioorg Med Chem; 2017 Aug; 25(16):4526-4531. PubMed ID: 28698054
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain.
    McShan D; Kathman S; Lowe B; Xu Z; Zhan J; Statsyuk A; Ogungbe IV
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4509-12. PubMed ID: 26342866
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
    Ettari R; Tamborini L; Angelo IC; Micale N; Pinto A; De Micheli C; Conti P
    J Med Chem; 2013 Jul; 56(14):5637-58. PubMed ID: 23611656
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
    Huang W; Zhang Z; Barros-Álvarez X; Koh CY; Ranade RM; Gillespie JR; Creason SA; Shibata S; Verlinde CLMJ; Hol WGJ; Buckner FS; Fan E
    Eur J Med Chem; 2016 Nov; 124():1081-1092. PubMed ID: 27788467
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
    Previti S; Ettari R; Cosconati S; Amendola G; Chouchene K; Wagner A; Hellmich UA; Ulrich K; Krauth-Siegel RL; Wich PR; Schmid I; Schirmeister T; Gut J; Rosenthal PJ; Grasso S; Zappalà M
    J Med Chem; 2017 Aug; 60(16):6911-6923. PubMed ID: 28763614
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei.
    Faria J; Moraes CB; Song R; Pascoalino BS; Lee N; Siqueira-Neto JL; Cruz DJ; Parkinson T; Ioset JR; Cordeiro-da-Silva A; Freitas-Junior LH
    J Biomol Screen; 2015 Jan; 20(1):70-81. PubMed ID: 25342146
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
    Maiwald F; Benítez D; Charquero D; Dar MA; Erdmann H; Preu L; Koch O; Hölscher C; Loaëc N; Meijer L; Comini MA; Kunick C
    Eur J Med Chem; 2014 Aug; 83():274-83. PubMed ID: 24973661
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors.
    Xin W; Li Z; Wang Q; Du J; Zhu M; Zhou H
    Eur J Med Chem; 2020 Jan; 185():111827. PubMed ID: 31732256
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.
    Troeberg L; Chen X; Flaherty TM; Morty RE; Cheng M; Hua H; Springer C; McKerrow JH; Kenyon GL; Lonsdale-Eccles JD; Coetzer TH; Cohen FE
    Mol Med; 2000 Aug; 6(8):660-9. PubMed ID: 11055585
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis.
    Ettari R; Previti S; Tamborini L; Cullia G; Grasso S; Zappalà M
    Mini Rev Med Chem; 2016; 16(17):1374-1391. PubMed ID: 27156518
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms.
    Steverding D; Rushworth SA; Florea BI; Overkleeft HS
    Mol Biochem Parasitol; 2020 Jan; 235():111246. PubMed ID: 31743688
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of an orally active nitrothiophene-based antitrypanosomal agent.
    Ajayi O; Metibemu DS; Crown O; Adeyinka OS; Kaiser M; Shoji N; Silva M; Rodriguez A; Ogungbe IV
    Eur J Med Chem; 2024 Jan; 263():115954. PubMed ID: 37984297
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.
    Herrmann FC; Lenz M; Jose J; Kaiser M; Brun R; Schmidt TJ
    Molecules; 2015 Sep; 20(9):16154-69. PubMed ID: 26404225
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
    Otoguro K; Iwatsuki M; Ishiyama A; Namatame M; Nishihara-Tukashima A; Kiyohara H; Hashimoto T; Asakawa Y; Omura S; Yamada H
    Phytochemistry; 2011 Nov; 72(16):2024-30. PubMed ID: 21843897
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.