BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 26249693)

  • 1. Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.
    Baum B; Lecker LS; Zoltner M; Jaenicke E; Schnell R; Hunter WN; Brenk R
    Acta Crystallogr F Struct Biol Commun; 2015 Aug; 71(Pt 8):1020-6. PubMed ID: 26249693
    [TBL] [Abstract][Full Text] [Related]  

  • 2. PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM.
    Drees SL; Li C; Prasetya F; Saleem M; Dreveny I; Williams P; Hennecke U; Emsley J; Fetzner S
    J Biol Chem; 2016 Mar; 291(13):6610-24. PubMed ID: 26811339
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural insights into bacterial resistance to cerulenin.
    Trajtenberg F; Altabe S; Larrieux N; Ficarra F; de Mendoza D; Buschiazzo A; Schujman GE
    FEBS J; 2014 May; 281(10):2324-38. PubMed ID: 24641521
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
    Wang J; Soisson SM; Young K; Shoop W; Kodali S; Galgoci A; Painter R; Parthasarathy G; Tang YS; Cummings R; Ha S; Dorso K; Motyl M; Jayasuriya H; Ondeyka J; Herath K; Zhang C; Hernandez L; Allocco J; Basilio A; Tormo JR; Genilloud O; Vicente F; Pelaez F; Colwell L; Lee SH; Michael B; Felcetto T; Gill C; Silver LL; Hermes JD; Bartizal K; Barrett J; Schmatz D; Becker JW; Cully D; Singh SB
    Nature; 2006 May; 441(7091):358-61. PubMed ID: 16710421
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH).
    Shang R; Liang J; Yi Y; Liu Y; Wang J
    Molecules; 2015 Sep; 20(9):16127-41. PubMed ID: 26404223
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility.
    Fisher M; Basak R; Kalverda AP; Fishwick CW; Turnbull WB; Nelson A
    Org Biomol Chem; 2014 Jan; 12(3):486-94. PubMed ID: 24276506
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.
    McMahon RM; Coinçon M; Tay S; Heras B; Morton CJ; Scanlon MJ; Martin JL
    Acta Crystallogr D Biol Crystallogr; 2015 Dec; 71(Pt 12):2386-95. PubMed ID: 26627647
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa.
    Uruburu M; Mastrangelo E; Bolognesi M; Ferrara S; Bertoni G; Milani M
    J Struct Biol; 2019 Mar; 205(3):18-25. PubMed ID: 30599211
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.
    Peterson RM; Huang T; Rudolf JD; Smanski MJ; Shen B
    Chem Biol; 2014 Mar; 21(3):389-397. PubMed ID: 24560608
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mapping a ketosynthase:acyl carrier protein binding interface via unnatural amino acid-mediated photo-cross-linking.
    Ye Z; Williams GJ
    Biochemistry; 2014 Dec; 53(48):7494-502. PubMed ID: 25427130
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD).
    Kutchma AJ; Hoang TT; Schweizer HP
    J Bacteriol; 1999 Sep; 181(17):5498-504. PubMed ID: 10464226
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Platensimycin and platencin congeners from Streptomyces platensis.
    Zhang C; Ondeyka J; Herath K; Jayasuriya H; Guan Z; Zink DL; Dietrich L; Burgess B; Ha SN; Wang J; Singh SB
    J Nat Prod; 2011 Mar; 74(3):329-40. PubMed ID: 21214253
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.
    Sainsbury S; Bird L; Rao V; Shepherd SM; Stuart DI; Hunter WN; Owens RJ; Ren J
    J Mol Biol; 2011 Jan; 405(1):173-84. PubMed ID: 20974151
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics.
    Espeland LO; Georgiou C; Klein R; Bhukya H; Haug BE; Underhaug J; Mainkar PS; Brenk R
    ChemMedChem; 2021 Sep; 16(17):2715-2726. PubMed ID: 34189850
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.
    Moynié L; Hope AG; Finzel K; Schmidberger J; Leckie SM; Schneider G; Burkart MD; Smith AD; Gray DW; Naismith JH
    J Mol Biol; 2016 Jan; 428(1):108-120. PubMed ID: 26562505
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
    Singh SB; Jayasuriya H; Ondeyka JG; Herath KB; Zhang C; Zink DL; Tsou NN; Ball RG; Basilio A; Genilloud O; Diez MT; Vicente F; Pelaez F; Young K; Wang J
    J Am Chem Soc; 2006 Sep; 128(36):11916-20. PubMed ID: 16953632
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis β-ketoacyl-acyl carrier protein reductase MabA.
    Küssau T; Flipo M; Van Wyk N; Viljoen A; Olieric V; Kremer L; Blaise M
    Acta Crystallogr D Struct Biol; 2018 May; 74(Pt 5):383-393. PubMed ID: 29717709
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
    Moynie L; Schnell R; McMahon SA; Sandalova T; Boulkerou WA; Schmidberger JW; Alphey M; Cukier C; Duthie F; Kopec J; Liu H; Jacewicz A; Hunter WN; Naismith JH; Schneider G
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2013 Jan; 69(Pt 1):25-34. PubMed ID: 23295481
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recent advances on platensimycin: a potential antimicrobial agent.
    Lu X; You Q
    Curr Med Chem; 2010; 17(12):1139-55. PubMed ID: 20158476
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Binding of NADP
    Blaise M; Van Wyk N; Banères-Roquet F; Guérardel Y; Kremer L
    Biochem J; 2017 Mar; 474(6):907-921. PubMed ID: 28126742
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.