352 related articles for article (PubMed ID: 26266576)
1. Enhanced Detection of Low-Abundance Host Cell Protein Impurities in High-Purity Monoclonal Antibodies Down to 1 ppm Using Ion Mobility Mass Spectrometry Coupled with Multidimensional Liquid Chromatography.
Doneanu CE; Anderson M; Williams BJ; Lauber MA; Chakraborty A; Chen W
Anal Chem; 2015 Oct; 87(20):10283-91. PubMed ID: 26266576
[TBL] [Abstract][Full Text] [Related]
2. Improved detection of host cell proteins (HCPs) in a mammalian cell-derived antibody drug using liquid chromatography/mass spectrometry in conjunction with an HCP-enrichment strategy.
Thompson JH; Chung WK; Zhu M; Tie L; Lu Y; Aboulaich N; Strouse R; Mo WD
Rapid Commun Mass Spectrom; 2014 Apr; 28(8):855-60. PubMed ID: 24623688
[TBL] [Abstract][Full Text] [Related]
3. Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry.
Doneanu CE; Xenopoulos A; Fadgen K; Murphy J; Skilton SJ; Prentice H; Stapels M; Chen W
MAbs; 2012; 4(1):24-44. PubMed ID: 22327428
[TBL] [Abstract][Full Text] [Related]
4. An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry.
Doneanu C; Fang J; Alelyunas Y; Yu YQ; Wrona M; Chen W
J Vis Exp; 2018 Apr; (134):. PubMed ID: 29733313
[TBL] [Abstract][Full Text] [Related]
5. Toward unbiased identification and comparative quantification of host cell protein impurities by automated iterative LC-MS/MS (HCP-AIMS) for therapeutic protein development.
Huang Y; Molden R; Hu M; Qiu H; Li N
J Pharm Biomed Anal; 2021 Jun; 200():114069. PubMed ID: 33901758
[TBL] [Abstract][Full Text] [Related]
6. A Novel Sample Preparation for Shotgun Proteomics Characterization of HCPs in Antibodies.
Huang L; Wang N; Mitchell CE; Brownlee T; Maple SR; De Felippis MR
Anal Chem; 2017 May; 89(10):5436-5444. PubMed ID: 28414239
[TBL] [Abstract][Full Text] [Related]
7. Quantitative host cell protein analysis using two dimensional data independent LC-MS(E).
Farrell A; Mittermayr S; Morrissey B; Mc Loughlin N; Navas Iglesias N; Marison IW; Bones J
Anal Chem; 2015 Sep; 87(18):9186-93. PubMed ID: 26280711
[TBL] [Abstract][Full Text] [Related]
8. Improved host cell protein analysis in monoclonal antibody products through ProteoMiner.
Chen IH; Xiao H; Li N
Anal Biochem; 2020 Dec; 610():113972. PubMed ID: 32979367
[TBL] [Abstract][Full Text] [Related]
9. Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment.
Chen IH; Xiao H; Daly T; Li N
Anal Chem; 2020 Mar; 92(5):3751-3757. PubMed ID: 31999105
[TBL] [Abstract][Full Text] [Related]
10. Toward the complete characterization of host cell proteins in biotherapeutics via affinity depletions, LC-MS/MS, and multivariate analysis.
Madsen JA; Farutin V; Carbeau T; Wudyka S; Yin Y; Smith S; Anderson J; Capila I
MAbs; 2015; 7(6):1128-37. PubMed ID: 26291024
[TBL] [Abstract][Full Text] [Related]
11. Identification and characterization of co-purifying CHO host cell proteins in monoclonal antibody purification process.
Liu X; Chen Y; Zhao Y; Liu-Compton V; Chen W; Payne G; Lazar AC
J Pharm Biomed Anal; 2019 Sep; 174():500-508. PubMed ID: 31234041
[TBL] [Abstract][Full Text] [Related]
12. Advanced mass spectrometry workflows for accurate quantification of trace-level host cell proteins in drug products: Benefits of FAIMS separation and gas-phase fractionation DIA.
Beaumal C; Beck A; Hernandez-Alba O; Carapito C
Proteomics; 2023 Aug; 23(16):e2300172. PubMed ID: 37148167
[TBL] [Abstract][Full Text] [Related]
13. Evaluating Immunogenicity Risk Due to Host Cell Protein Impurities in Antibody-Based Biotherapeutics.
Jawa V; Joubert MK; Zhang Q; Deshpande M; Hapuarachchi S; Hall MP; Flynn GC
AAPS J; 2016 Nov; 18(6):1439-1452. PubMed ID: 27450229
[TBL] [Abstract][Full Text] [Related]
14. Analysis of host-cell proteins in biotherapeutic proteins by LC/MS approaches.
Doneanu CE; Chen W
Methods Mol Biol; 2014; 1129():341-50. PubMed ID: 24648086
[TBL] [Abstract][Full Text] [Related]
15. Simple and Sensitive Method for Deep Profiling of Host Cell Proteins in Therapeutic Antibodies by Combining Ultra-Low Trypsin Concentration Digestion, Long Chromatographic Gradients, and BoxCar Mass Spectrometry Acquisition.
Nie S; Greer T; O'Brien Johnson R; Zheng X; Torri A; Li N
Anal Chem; 2021 Mar; 93(10):4383-4390. PubMed ID: 33656852
[TBL] [Abstract][Full Text] [Related]
16. Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product.
Bee JS; Tie L; Johnson D; Dimitrova MN; Jusino KC; Afdahl CD
Biotechnol Prog; 2015; 31(5):1360-9. PubMed ID: 26259961
[TBL] [Abstract][Full Text] [Related]
17. Identification and Quantification of a Problematic Host Cell Protein to Support Therapeutic Protein Development.
E SY; Hu Y; Molden R; Qiu H; Li N
J Pharm Sci; 2023 Mar; 112(3):673-679. PubMed ID: 36220394
[TBL] [Abstract][Full Text] [Related]
18. Identification and quantification of host cell protein impurities in biotherapeutics using mass spectrometry.
Schenauer MR; Flynn GC; Goetze AM
Anal Biochem; 2012 Sep; 428(2):150-7. PubMed ID: 22640604
[TBL] [Abstract][Full Text] [Related]
19. Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification.
Kreimer S; Gao Y; Ray S; Jin M; Tan Z; Mussa NA; Tao L; Li Z; Ivanov AR; Karger BL
Anal Chem; 2017 May; 89(10):5294-5302. PubMed ID: 28402653
[TBL] [Abstract][Full Text] [Related]
20. Characterization of drug-product-related impurities and variants of a therapeutic monoclonal antibody by higher energy C-trap dissociation mass spectrometry.
Wang D; Wynne C; Gu F; Becker C; Zhao J; Mueller HM; Li H; Shameem M; Liu YH
Anal Chem; 2015 Jan; 87(2):914-21. PubMed ID: 25513708
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
