These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
186 related articles for article (PubMed ID: 26268329)
21. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478 [TBL] [Abstract][Full Text] [Related]
22. [Beta- and gamma-secretases]. Iwatsubo T Rinsho Shinkeigaku; 2006 Nov; 46(11):925-6. PubMed ID: 17432221 [TBL] [Abstract][Full Text] [Related]
23. Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012. Pettersson M; Stepan AF; Kauffman GW; Johnson DS Expert Opin Ther Pat; 2013 Oct; 23(10):1349-66. PubMed ID: 23875696 [TBL] [Abstract][Full Text] [Related]
24. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Okochi M; Tagami S; Yanagida K; Takami M; Kodama TS; Mori K; Nakayama T; Ihara Y; Takeda M Cell Rep; 2013 Jan; 3(1):42-51. PubMed ID: 23291095 [TBL] [Abstract][Full Text] [Related]
25. Gamma-secretase as a pharmacological target in Alzheimer disease research: when, why and how? Ziani-Cherif C; Mostefa-Kara B; Brixi-Gormat FZ Curr Pharm Des; 2006; 12(33):4313-35. PubMed ID: 17105430 [TBL] [Abstract][Full Text] [Related]
26. Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Panza F; Solfrizzi V; Frisardi V; Capurso C; D'Introno A; Colacicco AM; Vendemiale G; Capurso A; Imbimbo BP Drugs Aging; 2009; 26(7):537-55. PubMed ID: 19655822 [TBL] [Abstract][Full Text] [Related]
27. Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option? Imbimbo BP; Panza F; Frisardi V; Solfrizzi V; D'Onofrio G; Logroscino G; Seripa D; Pilotto A Expert Opin Investig Drugs; 2011 Mar; 20(3):325-41. PubMed ID: 21222550 [TBL] [Abstract][Full Text] [Related]
28. γ-Secretase inhibitors and modulators for Alzheimer's disease. Wolfe MS J Neurochem; 2012 Jan; 120 Suppl 1(Suppl 1):89-98. PubMed ID: 22122056 [TBL] [Abstract][Full Text] [Related]
33. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893 [TBL] [Abstract][Full Text] [Related]
34. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. De Strooper B; Iwatsubo T; Wolfe MS Cold Spring Harb Perspect Med; 2012 Jan; 2(1):a006304. PubMed ID: 22315713 [TBL] [Abstract][Full Text] [Related]
35. γ-secretase substrates and their implications for drug development in Alzheimer's disease. Lleó A; Saura CA Curr Top Med Chem; 2011; 11(12):1513-27. PubMed ID: 21510835 [TBL] [Abstract][Full Text] [Related]
36. Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment. Li T; Huang Y; Jin S; Ye L; Rong N; Yang X; Ding Y; Cheng Z; Zhang J; Wan Z; Harrison DC; Hussain I; Hall A; Lee DH; Lau LF; Matsuoka Y J Neurochem; 2012 Apr; 121(2):277-86. PubMed ID: 22035227 [TBL] [Abstract][Full Text] [Related]
37. Decrease in catalytic capacity of γ-secretase can facilitate pathogenesis in sporadic and Familial Alzheimer's disease. Svedružić ŽM; Popović K; Šendula-Jengić V Mol Cell Neurosci; 2015 Jul; 67():55-65. PubMed ID: 26051801 [TBL] [Abstract][Full Text] [Related]
38. [Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity]. Tomita T Rinsho Shinkeigaku; 2009 Nov; 49(11):845-7. PubMed ID: 20030227 [TBL] [Abstract][Full Text] [Related]
39. Discovery of notch-sparing gamma-secretase inhibitors. Augelli-Szafran CE; Wei HX; Lu D; Zhang J; Gu Y; Yang T; Osenkowski P; Ye W; Wolfe MS Curr Alzheimer Res; 2010 May; 7(3):207-9. PubMed ID: 20088802 [TBL] [Abstract][Full Text] [Related]
40. The structure and function of Alzheimer's gamma secretase enzyme complex. Krishnaswamy S; Verdile G; Groth D; Kanyenda L; Martins RN Crit Rev Clin Lab Sci; 2009; 46(5-6):282-301. PubMed ID: 19958215 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]